A Dose Response Study to Evaluate the Efficacy and Safety of Oral AP1189 Administered in Disease-Modifying Anti-Rheumatic Drug (DMARD) naïve Participants Participants With Early Rheumatoid Arthritis

Study Purpose

The study is a randomized, double blind, placebo-controlled, dose response, phase II, multicentre trial to evaluate the efficacy and safety of oral AP1189 administered at the doses of 40, 70, or 100 mg for 12 weeks in combination with methotrexate, in DMARD-naïve participants with early rheumatoid arthritis and active inflammation.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Signed and dated informed consent obtained before undergoing any trial-specific procedure.
  • - Participants with definite RA diagnosis according to the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria.
  • - Disease duration no longer than 6 months from diagnosis at the time of Baseline Visit and with a history of RA symptoms which does not exceed 18 months.
  • - Participants must be naïve to any Disease-modifying anti-rheumatic drugs (DMARDs) - Participants with at least 6/68 tender and 6/66 swollen joints at Screening Visit and Baseline.
  • - Participants with "high" disease activity as documented by a Disease Activity Score 28 (DAS28) (C-Reactive Protein - CRP) index score > 5.1 at screening, and Clinical disease activity index (CDAI) >22 at Screening Visit and Baseline.
  • - Participants with serum high sensitive C-Reactive Protein (hsCRP) ≥3 mg/L at the time of screening.
  • - Participants positive for serum rheumatoid factor (RF), AND/OR anti-cyclic citrullinated peptide antibodies (anti-CCP).
If seronegative RA, hsCRP ≥6 mg/L at the time of screening.
  • - Willing and able to comply with the scheduled study visits, the treatment plan, and all study procedures.
  • - Females of childbearing potential must have a negative pregnancy test at screening and again at baseline.
  • - Sexually active female participants of childbearing potential and male participants are excluded if not practicing two different methods of birth control with their partner during the study and for 90 days after the last dose of study drug or who will not remain abstinent during the study and for 90 days after the last dose.

Exclusion Criteria:

  • - Functional class IV of Global Functional Status in RA, as defined by the ACR Classification.
  • - Rheumatic autoimmune disease other than RA, i.e. systemic lupus erythematosus, mixed connective tissue disease, scleroderma, polymyositis, or significant systemic involvement secondary to RA.
  • - Current inflammatory joint disease other than RA.
  • - Non-inflammatory type of musculoskeletal condition that in the Investigator's opinion is symptomatic and/or severe enough to interfere with the subject's primary diagnosis of RA or the evaluation of the effect of the study drug.
  • - Gastrointestinal diseases known to interfere with the absorption or excretion of medications.
  • - Severe, progressive, or uncontrolled renal, hepatic, hematologic, gastrointestinal, metabolic, endocrine, pulmonary, cardiac or neurologic disease.
  • - Malignancy active during the 12 months preceding the Screening Visit.
  • - Acute hepatitis, chronic hepatitis, or detection of any unexplained elevation of serum ALT or AST greater than 1.5-fold ULN, at least twice in the 6 months before the Screening Visit) or HIV infection.
  • - History of alcohol or drug abuse during the 12 months preceding the Screening Visit.
  • - Vaccination with live vaccines during the 6 weeks preceding the Screening Visit.
  • - Haemoglobin <9 g/dL or Haematocrit <30% at the Screening Visit.
  • - White blood cell (WBC) count <3.0 x 109/L at the Screening Visit.
  • - Absolute neutrophil count <1.2 x 109/L at the Screening Visit.
  • - Platelet count <100 x 109/L at the Screening Visit.
  • - Serum alkaline-phosphatase, or gamma-glutamyl-transferase greater than 3-fold ULN; alanine aminotransferase, or aspartate aminotransferase, or total bilirubin greater than 2-fold ULN At the Screening Visit.
  • - Estimated creatinine clearance less than 45 mL/min/1.73 m2 (MDRD) at the Screening Visit.
  • - 12-lead electrocardiogram (ECG) with abnormal clinically significant findings, as judged by the Investigator, at the Screening Visit.
  • - Positive QuantiFERON-in-Tube test (QFG-IT).
  • - Use of hydroxychloroquine during the 30 weeks preceding the Screening Visit.
  • - Treatment with any systemic or intraarticular corticosteroid within 6 weeks before the Screening Visit.
  • - Intermittent use of nonsteroidal anti-inflammatory drugs (NSAIDs).
Use of NSAIDs is allowed if used in a stable dose regimen for at least 4 weeks prior to the Screening Visit.
  • - Use of other investigational drugs/treatments, or enrolment in a clinical trial during the 6 months preceding the Screening Visit.
  • - Any other clinically relevant disease and condition that, in the opinion of the Investigator, may jeopardize efficacy or safety assessments or may compromise the subject's safety during trial participation.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT06671054
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

SynAct Pharma Aps
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

N/A
Principal Investigator Affiliation N/A
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Rheumatoid Arthritis (RA)
Additional Details

The purpose of the trial is to evaluate the efficacy, safety and tolerability of 12 weeks daily treatment of oral AP1189 at the doses of 40, 70, or 100 mg in combination with oral MTX compared to oral MTX alone. The aim is to have 240 participants randomized to one of the 4 treatment groups, in a 1:1:1:1 ratio and treated with both AP1189/Placebo and MTX.

Arms & Interventions

Arms

Experimental: AP1189 40 mg

12 weeks daily treatment of oral AP1189 40 mg as add-on to Methotrexate (MTX)

Experimental: AP1189 70 mg

12 weeks daily treatment of oral AP1189 70 mg as add-on to Methotrexate (MTX)

Experimental: AP1189 100 mg

12 weeks daily treatment of oral AP1189 100 mg as add-on to Methotrexate (MTX)

Experimental: Placebo

12 weeks daily treatment of oral AP1189 matching placebo as add-on to Methotrexate (MTX)

Interventions

Drug: - AP1189, 40 mg

AP1189 tablets for oral use

Drug: - AP1189, 70 mg

AP1189 tablets for oral use

Drug: - AP1189, 100 mg

AP1189 tablets for oral use

Drug: - AP1189 matching placebo

AP1189 tablets for oral use

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Altoona Center for Clinical Research, Duncansville, Pennsylvania

Status

Recruiting

Address

Altoona Center for Clinical Research

Duncansville, Pennsylvania, 16635

Site Contact

Alan Kiwitz, MD

[email protected]

+45 4015 6669