Clinical Trial Finder

Inclusion Criteria:

To be eligible to participate in this study, an individual must meet all the following criteria: 1. Provide informed consent, documented in a signed and dated form. 2. Will comply with all study procedures, including daily ratings filling before and after the in-person study visit, and be available for the study duration. 3. All participants of both genders between ages 18 to 74 years. 4. Cases and controls will be matched for age within ±5 years, and all participants must understand English commands to follow study procedures (e.g., during CPM testing). Pain-free controls: 1. Age matching (within ±5 years) 2. No previous diagnosis for the most common pain-related TMD as defined in the DC/TMD criteria (myalgia, arthralgia, headache attributed to TMD) 3. No significant orofacial pain (jaw pain, TMJ pain) in the past 3 months (""significant"" meaning 5 or more days in any month or any pain during the past month) 4. No report of significant pain in the last 3 months elsewhere in the body (""significant"" meaning 5 or more days in any month or any pain during the past month), e.g., low back pain, fibromyalgia, migraine headaches. 5. Not meeting any of the most common pain-related TMD diagnoses as described in the DC/TMD criteria (myalgia, arthralgia, headache attributed to TMD) upon clinical exam following the DC/TMD protocol.Chronic painful TMD cases: 1. Primary TMD case criteria: Myalgia (masticatory muscle pain) based on clinical exam following the DC/TMD protocol. 2. Concurrent arthralgia (TMJ pain) and/or headache attributed to TMD allowed. 3. Myofascial pain must meet the following criteria: 1. Onset >3 months, occurring >15 days/month on average for >3 months. 2. Minimum of 10 jaw pain episodes since onset, each lasting at least 30 minutes and no less than 2 hours within the day, OR unremitting."

Exclusion Criteria:

An individual who meets any of the following criteria will be excluded from participation in this study: 1. Traumatic facial injury or surgery on the face/jaw, arms, or hands. 2. Presence of pain related to dental and periodontal pathology. 3. Pregnant. 4. Has any of the following medical conditions by self-report: 1. Renal failure or dialysis. 2. Heart disease (examples: uncontrolled arrhythmia or hypertension, cardiomyopathy) or heart failure. 3. Non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema) 4. Diabetes (type I or II) that is not controlled with medication or diet. 5. Hyperthyroidism. 6. Uncontrolled seizures. 5. Used any injection therapy (e.g., tender or trigger point injections, steroid injections), acupuncture, biofeedback, or TENS for managing facial/jaw pain within 2 weeks before the screening assessment. 6. If undergoing botulinum toxin injections in the head and neck area, must be 3 months since the last set of injections, and refrain from this treatment until study participation has ended. 7. History of major depression or other major psychiatric disorder requiring inpatient hospitalization within the last 6 months before the screening assessment. 8. History of treatment for drug or alcohol abuse within the last 12 months. 9. Current pain medication use (e.g., opioids, ibuprofen, acetaminophen) that cannot be stopped <24 hours before each study visit. 10. Other conditions/diseases associated with altered pain perception: neurological or development disorders (dementia, autism spectrum disorder), neoplasm, multiple sclerosis, trigeminal neuralgia. 11. Adults lacking the capacity to provide informed consent for themselves. 12. Unable to understand instructions for sensory testing in English. 13. Thermal threshold for Pain-50 (pre-determined at the beginning of visit 1) is outside the temperature range of 40ºC to 49ºC. 14. Inability to complete at least four daily ratings between the Informed consent, Pre-visit 1 procedures, and in-person visit 1. 15. Lack of access to electronic devices with internet connection during the study participation. 16. Anything that would place the individual at increased risk or preclude the individual's full compliance with study procedures or completion of the study. "

Arms

: Chronic Temporomandibular disorder (TMD) pain group

: Age- and sex-matched pain-free controls

Interventions

Other: - Pain modulation testing

During the visit, noxious heat stimuli will be applied bilaterally to the face and distant body sites as part of conditioned pain modulation (CPM) testing. The test stimuli will be individually tailored to be moderately painful, while the conditioning stimulus will vary in intensity: moderately painful, non-painful, and sham heat. Participants will also record daily TMD pain intensity ratings for seven days before and after the visit.