Clinical Trial Finder

Inclusion Criteria:

Ability to read and speak English to allow for written informed consent and patient-reported outcomes measures.

• - Provision of signed and dated informed consent form.

• - Stated willingness to comply with all study procedures and availability for the duration of the study.

• - Ability to take oral medication and be willing to adhere to the study intervention regimen.

• - Diagnosis of rheumatoid arthritis by a medical provider, confirmed by checking medical records.

• - Current use of an RA treatment regimen of both oral prednisone and 1 other Food and Drug Administration-approved disease-modifying antirheumatic drug (DMARD), with no change in this therapy over the past 90 days.

1. Eligible DMARDs include the following: hydroxychloroquine, sulfasalazine, methotrexate, leflunomide, etanercept, adalimumab, infliximab, golimumab, certolizumab pegol, abatacept, tocilizumab, sarilumab, rituximab, tofacitinib, baricitinib, upadacitinib. 2. Patients enrolling in the 15-day taper must be taking 7.5mg/day oral prednisone. 3. Patients enrolling in the 150-day taper must be taking 5mg/day oral prednisone.

Exclusion Criteria:

Current or recent (past year) use of systemic glucocorticoid (oral, intravenous, or intramuscular administration) >2 weeks for an indication other than RA, to reduce risk of adverse health outcomes related to worsening of the indicated condition.

• - Patients with greater than moderate RA activity as determined by the Clinical Disease Activity Index or by rheumatologist assessment, given high likelihood of taper failure in this population due to increased RA activity alone.

• - Pre-existing primary or secondary adrenal insufficiency diagnosed by a physician, given high risk of worsening with prednisone taper.

• - Treatment with another investigational drug or intervention within 90 days.

• - Pregnancy.

• - Self-reported medical or psychiatric conditions that in the judgment of study personnel would preclude participation in this study (e.g., schizophrenia, malignancy, psychosis, suicidal ideation, history of substance abuse; note that stable anxiety and depression are NOT exclusions) - Current, recent (within the last 6 months), or habitual use of artificial nails or nail enhancements.

(Artificial nails can influence pressure pain sensitivity at the thumbnail); - Any impairment, activity, behavior, or situation that in the judgment of the study team would prevent satisfactory completion of the study protocol

This trial was changed, so that participants could participate remotely without coming into the clinic. For participants coming into the clinic, the clinical disease activity index (CDAI) will be used to measure objective intolerance to tapering. For remote participants, the Rheumatoid Arthritis Disease Activity Index (RADAI) will be used instead of the CDAI.

Arms

Experimental: 15-day taper prednisone

This will be for 30 days. Participants will be allocated to the 15-day strategy preferentially until enrollment goals have been met; once completing the 15-day strategy, many participants will also be eligible to complete the 150-day strategy, and may subsequently enroll in it if they wish. Participants that are not eligible for the 15-day strategy, but are eligible for the 150-day strategy, will be enrolled in the 150-day strategy.

Experimental: 150-day taper prednisone

This will be for 180 days. Participants who are not eligible for the 15-day strategy, but are eligible for the 150-day strategy, will be enrolled in the 150-day strategy.

Interventions

Drug: - 15-day taper prednisone

The 15-day taper group will assess the effect of an approximately 50% oral prednisone dose reduction over 15 days, and will be followed for an additional 15 days after the last dose reduction.

Drug: - 150-day taper prednisone

The 150-day taper group will assess the effect of reducing oral prednisone by 1 milligram (mg) every 30 days over 150 days, and will be followed for an additional 30 days after the last dose reduction.