Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

Study Purpose

Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will assess how safe and effective upadacitinib is in treating RA when compared to adalimumab in adult participants with inadequate response or intolerance to one TNF-inhibitor who are on a stable dose of methotrexate (MTX). Adverse events and change in disease activity will be assessed. Upadacitinib is an approved drug for the treatment of RA. This study is double-blinded means that neither the participants nor the study doctors will know who will be given upadacitinib and who will be given adalimumab. Study doctors put the participants in 1 of the 2 groups, called treatment arms randomly, to receive either upadacitinib or adalimumab. There is 1 in 2 chance that participants will receive adalimumab. Each group consists of 2 periods. Approximately 480 participants diagnosed with RA will be enrolled in approximately 250 sites across the world. Participants will receive the oral upadacitinib once daily and matching adalimumab placebo every other week, or the subcutaneous adalimumab every other week and matching upadacitinib placebo once daily during Period 1. Eligible participants will continue to receive same study treatment in Period 2 as assigned in Period 1 and will be followed for 30 days and 70 days. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, checking for side effects and completing questionnaires.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Diagnosis of Rheumatoid Arthritis (RA) for >= 3 months based on the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) classification criteria for RA.
  • - Treated for >= 3 consecutive months prior to screening with 1 tumor necrosis factor inhibitor (TNFi) (only 1 of originator or biosimilar certolizumab pegol, etanercept, golimumab or infliximab) for RA, but continue to exhibit active RA, or had to discontinue due to intolerability or toxicity, irrespective of treatment duration.
Up to 15% of participants who were intolerant to 1 TNFi will be allowed to enroll. Prior administration of different biosimilar versions for the same originator TNFi or switching between originator and biosimilar version of the same originator TNFi are acceptable. Cycling between biosimilars of different originator TNF inhibitors is not acceptable.
  • - On oral or parenteral methotrexate (MTX) therapy >= 3 consecutive months and on a stable prescription of 15 to 25 mg/week (or >= 10 mg/week in participants intolerant of MTX at doses >= 15 mg/week) for >= 4 weeks prior to the first dose of study drug.
In addition, all participants should take a dietary supplement of folic acid or folinic acid throughout the study participation.
  • - For a Chinese, Japanese, Korean, or Taiwanese participant, a stable dose of MTX >= 7.5 mg/week is acceptable.
  • - Additional local requirements for MTX may apply.
  • - Meets both of the following disease activity criteria: - >= 6 swollen joint (based on 66 joint counts) and >= 6 tender joints (based on 68 joint counts) at screening and baseline; - High-sensitivity C-reactive protein (hsCRP) >= 3 mg/L (central lab, upper limit of normal [ULN] 2.87 mg/L) at screening.

Exclusion Criteria:

  • - History of any arthritis with onset prior to age 17 years or current diagnosis of inflammatory joint disease other than Rheumatoid Arthritis (RA).
  • - Prior exposure to any janus kinase (JAK) inhibitor.
  • - Prior exposure to adalimumab (original or biosimilar) or to any approved or investigational TNF inhibitor other than infliximab, etanercept, certolizumab pegol and golimumab.
  • - Prior exposure to an approved or investigational non-TNFi biologic disease modifying anti-rheumatic drug (bDMARD) or targeted synthetic disease modifying antirheumatic drug (tsDMARD).

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT05814627
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

AbbVie
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

ABBVIE INC.
Principal Investigator Affiliation AbbVie
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Belgium, Brazil, Bulgaria, Canada, Chile, China, Colombia, Croatia, France, Germany, Greece, Hungary, Italy, Japan, Korea, Republic of, Mexico, Portugal, Puerto Rico, Romania, Serbia, South Africa, Spain, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Rheumatoid Arthritis
Study Website: View Trial Website
Arms & Interventions

Arms

Experimental: Upadacitinib+ Adalimumab matching Placebo

Participants will receive upadacitinib once a day along with matching placebo for adalimumab at eow (every other week) in Period 1. Eligible participants will continue to receive same study treatment in Period 2 as assigned in Period 1.

Experimental: Adalimumab + Upadacitinib matching Placebo

Participants will receive adalimumab at eow (every other week) along with matching placebo for upadacitinib once a day in Period 1. Eligible participants will continue to receive same study treatment in Period 2 as assigned in Period 1.

Interventions

Drug: - Upadacitinib

Oral Tablets

Drug: - Adalimumab

Subcutaneous Injection

Drug: - Upadacitinib Matching Placebo

Oral Tablets

Drug: - Adalimumab Matching Placebo

Subcutaneous Injection

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Flagstaff, Arizona

Status

Recruiting

Address

AZ Arthritis and Rheumotology Research, PLLC - Flagstaff /ID# 253431

Flagstaff, Arizona, 86001-6299

Glendale, Arizona

Status

Recruiting

Address

Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 255018

Glendale, Arizona, 85306-9802

Peoria, Arizona

Status

Recruiting

Address

Sun Valley Arthritis Center Ltd. /ID# 254654

Peoria, Arizona, 85381

Phoenix, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 253432

Phoenix, Arizona, 85032

Phoenix, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 255021

Phoenix, Arizona, 85032

Tucson, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatology Associates - Tucson /ID# 255017

Tucson, Arizona, 85704

Jonesboro, Arkansas

Status

Recruiting

Address

Arthritis and Rheumatism Associates /ID# 254013

Jonesboro, Arkansas, 72401-6251

Site Contact

Site Coordinator

[email protected]

870-333-2721

Fullerton, California

Status

Recruiting

Address

Providence - St. Jude Medical Center /ID# 252690

Fullerton, California, 92835

Huntington Beach, California

Status

Recruiting

Address

Newport Huntington Medical Group /ID# 252687

Huntington Beach, California, 92648-5994

La Mesa, California

Status

Recruiting

Address

Purushotham & Akther Kotha MD, Inc /ID# 252704

La Mesa, California, 91942

Site Contact

Site Coordinator

[email protected]

(619) 229-1995 x 208

Los Alamitos, California

Status

Recruiting

Address

Valerius Medical Group & Research Center of Greater Long Beach, Inc /ID# 252692

Los Alamitos, California, 90720-5402

San Diego, California

Status

Recruiting

Address

Rheumatology Center of San Diego /ID# 255038

San Diego, California, 92128-2549

Millennium Clinical Trials /ID# 252689, Thousand Oaks, California

Status

Recruiting

Address

Millennium Clinical Trials /ID# 252689

Thousand Oaks, California, 91360-3951

Torrance, California

Status

Recruiting

Address

The Lundquist Institute at Harbor-UCLA Medical Center /ID# 252691

Torrance, California, 90502

Woodland Hills, California

Status

Recruiting

Address

Comprehensive Rheumatology Center /ID# 252688

Woodland Hills, California, 91364

Aurora, Colorado

Status

Recruiting

Address

University of Colorado Hospital /ID# 254617

Aurora, Colorado, 80045

Denver Arthritis Clinic /ID# 254058, Denver, Colorado

Status

Completed

Address

Denver Arthritis Clinic /ID# 254058

Denver, Colorado, 80230

Tekton Research /ID# 255036, Fort Collins, Colorado

Status

Recruiting

Address

Tekton Research /ID# 255036

Fort Collins, Colorado, 80528

Aventura, Florida

Status

Recruiting

Address

Arthritis and Rheumatic Disease Specialties /ID# 260583

Aventura, Florida, 33180

Boca Raton, Florida

Status

Recruiting

Address

Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 253733

Boca Raton, Florida, 33486

Bay Area Arthritis and Osteo /ID# 254046, Brandon, Florida

Status

Recruiting

Address

Bay Area Arthritis and Osteo /ID# 254046

Brandon, Florida, 33511

Site Contact

Site Coordinator

[email protected]

813-651-4441

Believe Clinical Trials /ID# 262355, Coral Springs, Florida

Status

Recruiting

Address

Believe Clinical Trials /ID# 262355

Coral Springs, Florida, 33065

Daytona Beach, Florida

Status

Recruiting

Address

International Medical Research /ID# 254651

Daytona Beach, Florida, 32117

Omega Research Debary, LLC /ID# 253735, DeBary, Florida

Status

Recruiting

Address

Omega Research Debary, LLC /ID# 253735

DeBary, Florida, 32713-2260

Neoclinical Research /ID# 254622, Hialeah, Florida

Status

Recruiting

Address

Neoclinical Research /ID# 254622

Hialeah, Florida, 33016-1897

Site Contact

Site Coordinator

[email protected]

305-456-9062

Life Clinical Trials /ID# 256061, Margate, Florida

Status

Recruiting

Address

Life Clinical Trials /ID# 256061

Margate, Florida, 33063

Lakes Research, LLC /ID# 255023, Miami, Florida

Status

Completed

Address

Lakes Research, LLC /ID# 255023

Miami, Florida, 33014

HMD Research LLC /ID# 253732, Orlando, Florida

Status

Recruiting

Address

HMD Research LLC /ID# 253732

Orlando, Florida, 32819

Millennium Research /ID# 253744, Ormond Beach, Florida

Status

Recruiting

Address

Millennium Research /ID# 253744

Ormond Beach, Florida, 32174

BayCare Medical Group /ID# 253799, Saint Petersburg, Florida

Status

Recruiting

Address

BayCare Medical Group /ID# 253799

Saint Petersburg, Florida, 33705

Tampa, Florida

Status

Recruiting

Address

Clinical Research of West Florida - Tampa /ID# 255264

Tampa, Florida, 33606-1246

Tampa, Florida

Status

Recruiting

Address

Clinical Research of West Florida, Inc /ID# 254649

Tampa, Florida, 33606-1246

Tampa, Florida

Status

Recruiting

Address

University of South Florida- Neuroscience Institute /ID# 253745

Tampa, Florida, 33613

BayCare Medical Group, Inc. /ID# 255268, Tampa, Florida

Status

Recruiting

Address

BayCare Medical Group, Inc. /ID# 255268

Tampa, Florida, 33614-7101

Site Contact

Site Coordinator

[email protected]

813-840-3600

Marietta, Georgia

Status

Recruiting

Address

Atlanta Research Center for Rheumatology /ID# 254623

Marietta, Georgia, 20060

Hinsdale Orthopaedics /ID# 254712, Hinsdale, Illinois

Status

Recruiting

Address

Hinsdale Orthopaedics /ID# 254712

Hinsdale, Illinois, 60521

Deerbrook Medical Associates /ID# 254008, Libertyville, Illinois

Status

Recruiting

Address

Deerbrook Medical Associates /ID# 254008

Libertyville, Illinois, 60048

Site Contact

Site Coordinator

[email protected]

1-867-367-7340

OrthoIllinois /ID# 254057, Rockford, Illinois

Status

Recruiting

Address

OrthoIllinois /ID# 254057

Rockford, Illinois, 61114-4937

Schaumburg, Illinois

Status

Recruiting

Address

Greater Chicago Specialty Physicians /ID# 254000

Schaumburg, Illinois, 60195-3106

Skokie, Illinois

Status

Recruiting

Address

Clinic Of Dr. Robert Hozman/Clinical Investigation Specialists, Inc /ID# 253999

Skokie, Illinois, 60076

Evansville, Indiana

Status

Recruiting

Address

Qualmedica Research - Evansville /ID# 254005

Evansville, Indiana, 47715-2813

Western KY Rheumatology /ID# 255026, Hopkinsville, Kentucky

Status

Recruiting

Address

Western KY Rheumatology /ID# 255026

Hopkinsville, Kentucky, 42240

Site Contact

Site Coordinator

[email protected]

270-885-3876

Bluegrass Community Research /ID# 254653, Lexington, Kentucky

Status

Completed

Address

Bluegrass Community Research /ID# 254653

Lexington, Kentucky, 40504

Ochsner Clinic Foundation /ID# 254059, Baton Rouge, Louisiana

Status

Recruiting

Address

Ochsner Clinic Foundation /ID# 254059

Baton Rouge, Louisiana, 70836-6455

Monroe, Louisiana

Status

Recruiting

Address

The Arthritis & Diabetes Clinic, Inc. /ID# 254014

Monroe, Louisiana, 71203

Portland, Maine

Status

Recruiting

Address

Rheumatology Associates PA - Portland /ID# 255014

Portland, Maine, 04102-2643

Boston, Massachusetts

Status

Recruiting

Address

Beth Israel Deaconess Medical Center - Rheumatology /ID# 255029

Boston, Massachusetts, 02149-4903

Grand Blanc, Michigan

Status

Recruiting

Address

AA Medical Research Center - Grand Blanc /ID# 254007

Grand Blanc, Michigan, 48439

Site Contact

Site Coordinator

[email protected]

810-694-0082

Advanced Rheumatology, PC /ID# 256059, Lansing, Michigan

Status

Recruiting

Address

Advanced Rheumatology, PC /ID# 256059

Lansing, Michigan, 48910

St. Paul Rheumatology, PA /ID# 255037, Eagan, Minnesota

Status

Recruiting

Address

St. Paul Rheumatology, PA /ID# 255037

Eagan, Minnesota, 55121

Arthritis Associates /ID# 253992, Hattiesburg, Mississippi

Status

Recruiting

Address

Arthritis Associates /ID# 253992

Hattiesburg, Mississippi, 39402

Kansas City, Missouri

Status

Recruiting

Address

Kansas City Physician Partners /ID# 255035

Kansas City, Missouri, 64151

Clinvest Research LLC /ID# 254054, Springfield, Missouri

Status

Recruiting

Address

Clinvest Research LLC /ID# 254054

Springfield, Missouri, 65807

Logan Health Research /ID# 253738, Kalispell, Montana

Status

Recruiting

Address

Logan Health Research /ID# 253738

Kalispell, Montana, 59901

Lincoln, Nebraska

Status

Recruiting

Address

Physician Research Collaboration, LLC /ID# 254012

Lincoln, Nebraska, 68516

Lebanon, New Hampshire

Status

Recruiting

Address

Dartmouth-Hitchcock Medical Center /ID# 253798

Lebanon, New Hampshire, 03756

Voorhees, New Jersey

Status

Recruiting

Address

Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 255266

Voorhees, New Jersey, 08043

Las Cruces, New Mexico

Status

Recruiting

Address

Arthritis and Osteoporosis Associates of New Mexico /ID# 252684

Las Cruces, New Mexico, 88011

Brooklyn, New York

Status

Recruiting

Address

NYU Langone Ambulatory Care Brooklyn Heights /ID# 254621

Brooklyn, New York, 11201

Minot, North Dakota

Status

Recruiting

Address

Trinity Health Med Arts Clinic /ID# 254010

Minot, North Dakota, 58701

Middleburg Heights, Ohio

Status

Recruiting

Address

Paramount Medical Research and Consulting /ID# 254048

Middleburg Heights, Ohio, 44130

Site Contact

Site Coordinator

[email protected]

440-826-0742

Oklahoma City, Oklahoma

Status

Recruiting

Address

Rheumatology Associates of Oklahoma /ID# 253994

Oklahoma City, Oklahoma, 73116-7226

Philadelphia, Pennsylvania

Status

Recruiting

Address

Clinical Research of Philadelphia, LLC /ID# 255025

Philadelphia, Pennsylvania, 19114

Site Contact

Site Coordinator

[email protected]

212-676-6696

Jackson, Tennessee

Status

Recruiting

Address

West Tennessee Research Institute /ID# 254620

Jackson, Tennessee, 38305

Allen, Texas

Status

Recruiting

Address

Arthritis and Rheumatology Research Institute, PLLC /ID# 254045

Allen, Texas, 75013-6147

Site Contact

Site Coordinator

[email protected]

(972) 798-8553

Tekton Research, Inc. /ID# 254004, Austin, Texas

Status

Recruiting

Address

Tekton Research, Inc. /ID# 254004

Austin, Texas, 78745

Site Contact

Site Coordinator

[email protected]

512-388-5717

Carrollton, Texas

Status

Recruiting

Address

Trinity Universal Research Associates - Carrollton /ID# 254648

Carrollton, Texas, 75007

Corpus Christi, Texas

Status

Recruiting

Address

Adriana Pop-Moody MD Clinic PA /ID# 255030

Corpus Christi, Texas, 78404

Site Contact

Site Coordinator

[email protected]

361-885-0010

JPS Rheumatology Clinic /ID# 254050, Fort Worth, Texas

Status

Recruiting

Address

JPS Rheumatology Clinic /ID# 254050

Fort Worth, Texas, 76104-4917

Houston, Texas

Status

Recruiting

Address

Biopharma Informatic - Houston - Business Center Drive /ID# 254051

Houston, Texas, 77043

Houston, Texas

Status

Recruiting

Address

Biopharma Informatic - Houston - Business Center Drive /ID# 254053

Houston, Texas, 77043

Accurate Clinical Research /ID# 254647, Houston, Texas

Status

Recruiting

Address

Accurate Clinical Research /ID# 254647

Houston, Texas, 77089

Katy, Texas

Status

Recruiting

Address

R & H Clinical Research - 777 Katy /ID# 255024

Katy, Texas, 77450-2244

West Texas Clinical Research /ID# 253736, Lubbock, Texas

Status

Recruiting

Address

West Texas Clinical Research /ID# 253736

Lubbock, Texas, 79424

Site Contact

Site Coordinator

[email protected]

8069931040

Plano, Texas

Status

Recruiting

Address

Trinity Universal Research Associates, Inc /ID# 253995

Plano, Texas, 75024-5283

Sun Research Institute /ID# 255019, San Antonio, Texas

Status

Recruiting

Address

Sun Research Institute /ID# 255019

San Antonio, Texas, 78215

The Woodlands, Texas

Status

Recruiting

Address

Advanced Rheumatology of Houston /ID# 254003

The Woodlands, Texas, 77382

Site Contact

Site Coordinator

[email protected]

281-766-7886

Tomball, Texas

Status

Recruiting

Address

DM Clinical Research - Tomball /ID# 254001

Tomball, Texas, 77375

Tomball, Texas

Status

Recruiting

Address

Rheumatology Clinic of Houston /ID# 254002

Tomball, Texas, 77377

Site Contact

Site Coordinator

[email protected]

2815170550

Franklin, Wisconsin

Status

Recruiting

Address

Aurora Rheumatology and Immunotherapy Center /ID# 254049

Franklin, Wisconsin, 53132

Glendale, Wisconsin

Status

Recruiting

Address

Rheumatic Disease Center, LLP /ID# 254015

Glendale, Wisconsin, 53217

International Sites

UZ Gent /ID# 252306, Gent, Oost-Vlaanderen, Belgium

Status

Recruiting

Address

UZ Gent /ID# 252306

Gent, Oost-Vlaanderen, 9000

ReumaClinic /ID# 252277, Genk, Belgium

Status

Recruiting

Address

ReumaClinic /ID# 252277

Genk, , 3600

CHU de Liege /ID# 252309, Liege, Belgium

Status

Recruiting

Address

CHU de Liege /ID# 252309

Liege, , 4000

Curitiba, Parana, Brazil

Status

Recruiting

Address

CETI - Centro de Estudos em Terapias Inovadoras /ID# 254201

Curitiba, Parana, 80030-110

LMK Sevicos Medicos S/S /ID# 254202, Porto Alegre, Rio Grande Do Sul, Brazil

Status

Recruiting

Address

LMK Sevicos Medicos S/S /ID# 254202

Porto Alegre, Rio Grande Do Sul, 90480-000

Sao Jose Do Rio Preto, Sao Paulo, Brazil

Status

Recruiting

Address

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 254917

Sao Jose Do Rio Preto, Sao Paulo, 15090-000

Sao Paulo, Brazil

Status

Recruiting

Address

CEPIC - Centro Paulista de Investigacao Clinica /ID# 254200

Sao Paulo, , 04266-010

UMHAT Kaspela EOOD /ID# 252343, Plovdiv, Bulgaria

Status

Recruiting

Address

UMHAT Kaspela EOOD /ID# 252343

Plovdiv, , 4001

Medical center Unimed /ID# 252344, Plovdiv, Bulgaria

Status

Recruiting

Address

Medical center Unimed /ID# 252344

Plovdiv, , 4023

MHAT Plovdiv /ID# 252342, Plovdiv, Bulgaria

Status

Recruiting

Address

MHAT Plovdiv /ID# 252342

Plovdiv, , 4027

Sofia, Bulgaria

Status

Recruiting

Address

Diagnostic consultative center 17 Sofia /ID# 252341

Sofia, , 1505

Sofia, Bulgaria

Status

Recruiting

Address

Military Medical Academy Multiprofile Hospital /ID# 252355

Sofia, , 1606

Sofiya, Bulgaria

Status

Recruiting

Address

Diagnostic consultative center Focus-5 /ID# 252354

Sofiya, , 1463

Sofiya, Bulgaria

Status

Recruiting

Address

Diagnostic consultative center Focus-5 /ID# 252555

Sofiya, , 1463

Manitoba Clinic /ID# 254019, Winnipeg, Manitoba, Canada

Status

Recruiting

Address

Manitoba Clinic /ID# 254019

Winnipeg, Manitoba, R3A 1M3

Centre Rhumatologie de l'Est /ID# 254932, Rimouski, Quebec, Canada

Status

Recruiting

Address

Centre Rhumatologie de l'Est /ID# 254932

Rimouski, Quebec, G5L 8W1

Sainte-foy, Quebec, Canada

Status

Recruiting

Address

Groupe de Recherche en Maladies Osseuses Inc /ID# 253409

Sainte-foy, Quebec, G1V 3M7

Trois-rivières, Quebec, Canada

Status

Recruiting

Address

Centre de Recherche Musculo-Squelettique /ID# 256273

Trois-rivières, Quebec, G8Z 1Y2

Saskatoon, Saskatchewan, Canada

Status

Recruiting

Address

Dr Naik-Medical Professional Corporation-Alliance Health /ID# 254018

Saskatoon, Saskatchewan, S7H 5M7

Osorno, Los Lagos, Chile

Status

Recruiting

Address

Corporacion de Beneficiencia Osorno /ID# 252556

Osorno, Los Lagos, 1710216

Santiago, Region Metropolitana De Santiago, Chile

Status

Recruiting

Address

Complejo Asistencial Dr. Sotero del Rio /ID# 252559

Santiago, Region Metropolitana De Santiago, 8207257

Clinica Dermacross /ID# 252560, Vitacura, Region Metropolitana Santiago, Chile

Status

Recruiting

Address

Clinica Dermacross /ID# 252560

Vitacura, Region Metropolitana Santiago, 7640881

Santiago, Chile

Status

Recruiting

Address

Centro Internacional de Estudios Clinicos - CIEC /ID# 252561

Santiago, , 8420383

Bengbu, Anhui, China

Status

Recruiting

Address

The first affiliated hospital of bengbu medical college /ID# 252612

Bengbu, Anhui, 233004

Beijing, Beijing, China

Status

Recruiting

Address

Peking University First Hospital /ID# 252392

Beijing, Beijing, 100034

Beijing, Beijing, China

Status

Recruiting

Address

Peking University Third Hospital /ID# 252393

Beijing, Beijing, 100191

Guangzhou, Guangdong, China

Status

Recruiting

Address

The Third Affiliated Hospital, Sun Yat-Sen University /ID# 252394

Guangzhou, Guangdong, 510630

Zhuzhou Central Hospital /ID# 252390, Zhuzhou, Hunan, China

Status

Recruiting

Address

Zhuzhou Central Hospital /ID# 252390

Zhuzhou, Hunan, 412007

Nanjing Drum Tower Hospital /ID# 252613, Nanjing, Jiangsu, China

Status

Recruiting

Address

Nanjing Drum Tower Hospital /ID# 252613

Nanjing, Jiangsu, 210008

Pingxiang, Jiangxi, China

Status

Recruiting

Address

Jiangxi Pingxiang People's Hospital /ID# 252381

Pingxiang, Jiangxi, 337055

Chengdu, Sichuan, China

Status

Recruiting

Address

West China Hospital, Sichuan University /ID# 252364

Chengdu, Sichuan, 610041

Barranquilla, Atlantico, Colombia

Status

Recruiting

Address

Centro Integral de Reumatología del Caribe SAS - Circaribe SAS /ID# 252587

Barranquilla, Atlantico, 80002

Bogotá, Cundinamarca, Colombia

Status

Recruiting

Address

Centro de Investigacion en Reumatologia y especialidades Medicas S.A.S- CIREEM /ID# 252586

Bogotá, Cundinamarca, 110221

Healthy Medical Center S.A.S /ID# 252585, Zipaquirá, Cundinamarca, Colombia

Status

Recruiting

Address

Healthy Medical Center S.A.S /ID# 252585

Zipaquirá, Cundinamarca, 250252

Poliklinika Repromed /ID# 252451, Zagreb, Grad Zagreb, Croatia

Status

Recruiting

Address

Poliklinika Repromed /ID# 252451

Zagreb, Grad Zagreb, 10000

Poliklinika Solmed /ID# 252453, Grad Zagreb, Croatia

Status

Recruiting

Address

Poliklinika Solmed /ID# 252453

Grad Zagreb, , 10000

Krapinske Toplice, Croatia

Status

Recruiting

Address

Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice /ID# 252455

Krapinske Toplice, , 49217

Medical Center Kuna-Peric /ID# 252452, Zagreb, Croatia

Status

Recruiting

Address

Medical Center Kuna-Peric /ID# 252452

Zagreb, , 10000

Poliklinika Bonifarm /ID# 252741, Zagreb, Croatia

Status

Recruiting

Address

Poliklinika Bonifarm /ID# 252741

Zagreb, , 10000

TOULOUSE Cedex 9, Haute-Garonne, France

Status

Recruiting

Address

CHU Toulouse - Hopital Purpan /ID# 252402

TOULOUSE Cedex 9, Haute-Garonne, 31059

Montpellier, Herault, France

Status

Recruiting

Address

CHU Montpellier - Hôpital Lapeyronie /ID# 252386

Montpellier, Herault, 34090

CHU Nice -Hopital Pasteur /ID# 254224, Nice CEDEX 1, Provence-Alpes-Cote-d Azur, France

Status

Recruiting

Address

CHU Nice -Hopital Pasteur /ID# 254224

Nice CEDEX 1, Provence-Alpes-Cote-d Azur, 06002

CHU Amiens-Picardie Site Sud /ID# 252384, Amiens CEDEX 1, Somme, France

Status

Recruiting

Address

CHU Amiens-Picardie Site Sud /ID# 252384

Amiens CEDEX 1, Somme, 80054

Orléans, France

Status

Recruiting

Address

Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 252385

Orléans, , 45067

Hôpital Charles-Nicolle /ID# 252908, Rouen, France

Status

Recruiting

Address

Hôpital Charles-Nicolle /ID# 252908

Rouen, , 76000

Templin, Brandenburg, Germany

Status

Recruiting

Address

Rheumatologische-Immunologische Praxis Templin /ID# 252863

Templin, Brandenburg, 17268

Rheumazentrum Ruhrgebiet /ID# 252670, Herne, Germany

Status

Recruiting

Address

Rheumazentrum Ruhrgebiet /ID# 252670

Herne, , 44649

Planegg, Germany

Status

Recruiting

Address

Klinische Forschung im med. Versorgungsalltag GbR /ID# 254221

Planegg, , 82152

Rheumazentrum Ratingen /ID# 252669, Ratingen, Germany

Status

Recruiting

Address

Rheumazentrum Ratingen /ID# 252669

Ratingen, , 40882

Athens, Attiki, Greece

Status

Recruiting

Address

General Hospital of Athens Laiko /ID# 252258

Athens, Attiki, 11527

Athens, Attiki, Greece

Status

Recruiting

Address

University General Hospital Attikon /ID# 254751

Athens, Attiki, 12462

Heraklion, Kriti, Greece

Status

Recruiting

Address

University General Hospital of Heraklion PA.G.N.I /ID# 252261

Heraklion, Kriti, 71500

Site Contact

Site Coordinator

[email protected]

+30-281-039-2024

Vital Medicina Kft /ID# 252399, Veszprém, Veszprem, Hungary

Status

Recruiting

Address

Vital Medicina Kft /ID# 252399

Veszprém, Veszprem, 8200

Budapest, Hungary

Status

Recruiting

Address

Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 253311

Budapest, , 1023

Szekesfehervar, Hungary

Status

Recruiting

Address

CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 252400

Szekesfehervar, , 8000

MÁV Kórház /ID# 252628, Szolnok, Hungary

Status

Recruiting

Address

MÁV Kórház /ID# 252628

Szolnok, , 5000

Torette, Ancona, Italy

Status

Recruiting

Address

Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 252459

Torette, Ancona, 60020

Florence, Italy

Status

Recruiting

Address

Azienda Ospedaliero Universitaria Careggi /ID# 252460

Florence, , 50134

Milan, Italy

Status

Recruiting

Address

ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 252461

Milan, , 20122

Nagoya-shi, Aichi, Japan

Status

Recruiting

Address

Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 252836

Nagoya-shi, Aichi, 455-8530

Daido Clinic /ID# 253058, Nagoya-shi, Aichi, Japan

Status

Recruiting

Address

Daido Clinic /ID# 253058

Nagoya-shi, Aichi, 457-8511

Fukui-shi, Fukui, Japan

Status

Recruiting

Address

Sugimoto Rheumatology and Internal Medicine Clinic /ID# 252774

Fukui-shi, Fukui, 910-0068

Hamanomachi Hospital /ID# 253168, Fukuoka-shi, Fukuoka, Japan

Status

Recruiting

Address

Hamanomachi Hospital /ID# 253168

Fukuoka-shi, Fukuoka, 810-8539

Shono Rheumatism Clinic /ID# 252591, Fukuoka-shi, Fukuoka, Japan

Status

Recruiting

Address

Shono Rheumatism Clinic /ID# 252591

Fukuoka-shi, Fukuoka, 814-0002

Asahikawa-shi, Hokkaido, Japan

Status

Recruiting

Address

Katayama Orthopedic Rheumatology Clinic /ID# 252746

Asahikawa-shi, Hokkaido, 078-8243

Sapporo-shi, Hokkaido, Japan

Status

Recruiting

Address

Sagawa Akira Rheumatology Clin /ID# 252773

Sapporo-shi, Hokkaido, 060-0001

Matsubara Mayflower Hospital /ID# 252834, Kato-shi, Hyogo, Japan

Status

Recruiting

Address

Matsubara Mayflower Hospital /ID# 252834

Kato-shi, Hyogo, 673-1462

Sanuki Municipal Hospital /ID# 252747, Sanuki-shi, Kagawa, Japan

Status

Recruiting

Address

Sanuki Municipal Hospital /ID# 252747

Sanuki-shi, Kagawa, 769-2393

Kochi-shi, Kochi, Japan

Status

Recruiting

Address

Bay Side Misato Medical Center /ID# 252661

Kochi-shi, Kochi, 781-0112

Kumamoto shi, Kumamoto, Japan

Status

Recruiting

Address

Kumamoto Orthopaedic Hospital /ID# 253167

Kumamoto shi, Kumamoto, 8620975

Miyazaki-shi, Miyazaki, Japan

Status

Recruiting

Address

Medical Corporation Keiai Kai Clinic /ID# 252750

Miyazaki-shi, Miyazaki, 880-0053

Sasebo Chuo Hospital /ID# 252662, Sasebo-shi, Nagasaki, Japan

Status

Recruiting

Address

Sasebo Chuo Hospital /ID# 252662

Sasebo-shi, Nagasaki, 857-1195

Chuo-ku, Tokyo, Japan

Status

Recruiting

Address

St.Luke's International Hospital /ID# 253131

Chuo-ku, Tokyo, 104-8560

Keio University Hospital /ID# 253205, Shinjuku-ku, Tokyo, Japan

Status

Recruiting

Address

Keio University Hospital /ID# 253205

Shinjuku-ku, Tokyo, 160-8582

Shimonoseki-shi, Yamaguchi, Japan

Status

Recruiting

Address

Tokito Clinic Rheumatology and Orthopaedics Surgery /ID# 253057

Shimonoseki-shi, Yamaguchi, 752-0976

Cheonan-si, Chungcheongnamdo, Korea, Republic of

Status

Recruiting

Address

SoonChunHyang University Hospital Cheonan /ID# 254942

Cheonan-si, Chungcheongnamdo, 31151

Daejeon, Daejeon Gwang Yeogsi, Korea, Republic of

Status

Recruiting

Address

Chungnam National University Hospital /ID# 252159

Daejeon, Daejeon Gwang Yeogsi, 35015

Gwangju, Gwangju Gwang Yeogsi, Korea, Republic of

Status

Recruiting

Address

Chonnam National University Bitgoeul Hospital /ID# 254802

Gwangju, Gwangju Gwang Yeogsi, 61748

Seoul, Seoul Teugbyeolsi, Korea, Republic of

Status

Recruiting

Address

Hanyang University Seoul Hospital /ID# 252161

Seoul, Seoul Teugbyeolsi, 04763

Seoul, Korea, Republic of

Status

Recruiting

Address

Seoul National University Hospital /ID# 252160

Seoul, , 03080

Mexico City, Ciudad De Mexico, Mexico

Status

Recruiting

Address

CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 252873

Mexico City, Ciudad De Mexico, 11850

Hospital de Jesus /ID# 253114, Mexico City, Distrito Federal, Mexico

Status

Recruiting

Address

Hospital de Jesus /ID# 253114

Mexico City, Distrito Federal, 06090

Guadalajara, Jalisco, Mexico

Status

Recruiting

Address

Centro Integral en Reumatologia S.A de C.V /ID# 252872

Guadalajara, Jalisco, 44160

Guadalajara, Jalisco, Mexico

Status

Recruiting

Address

Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 253480

Guadalajara, Jalisco, 44650

Chihuahua, Mexico

Status

Recruiting

Address

Investigacion y Biomedicina de Chihuahua /ID# 253115

Chihuahua, , 31000

Hospital Garcia de Orta /ID# 252491, Almada, Setubal, Portugal

Status

Recruiting

Address

Hospital Garcia de Orta /ID# 252491

Almada, Setubal, 2805-267

Ponte de Lima, Viana Do Castelo, Portugal

Status

Recruiting

Address

Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 252489

Ponte de Lima, Viana Do Castelo, 4990-041

Lisboa, Portugal

Status

Recruiting

Address

Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 252492

Lisboa, , 1649-035

GCM Medical Group PSC /ID# 252700, San Juan, Puerto Rico

Status

Recruiting

Address

GCM Medical Group PSC /ID# 252700

San Juan, , 00917-3104

Mindful Medical Research /ID# 252693, San Juan, Puerto Rico

Status

Recruiting

Address

Mindful Medical Research /ID# 252693

San Juan, , 00918-3756

Timisoara, Timis, Romania

Status

Recruiting

Address

Cabinet Medical Dr. Avram S.R.L /ID# 254133

Timisoara, Timis, 300134

Banat Carina Med SRL /ID# 252757, Timisoara, Timis, Romania

Status

Recruiting

Address

Banat Carina Med SRL /ID# 252757

Timisoara, Timis, 300766

Bacau, Romania

Status

Recruiting

Address

Spitalul Judetean de Urgenta Bacau /ID# 252860

Bacau, , 600114

Spitalul Clinic Sf. Maria /ID# 252759, Bucuresti, Romania

Status

Recruiting

Address

Spitalul Clinic Sf. Maria /ID# 252759

Bucuresti, , 011172

Spitalul Clinic Sf. Maria /ID# 253334, Bucuresti, Romania

Status

Recruiting

Address

Spitalul Clinic Sf. Maria /ID# 253334

Bucuresti, , 011172

Institute for Rheumatology /ID# 252333, Belgrade, Beograd, Serbia

Status

Recruiting

Address

Institute for Rheumatology /ID# 252333

Belgrade, Beograd, 11000

Institute for Rheumatology /ID# 252334, Belgrade, Beograd, Serbia

Status

Recruiting

Address

Institute for Rheumatology /ID# 252334

Belgrade, Beograd, 11000

Institute for Rheumatology /ID# 252335, Belgrade, Beograd, Serbia

Status

Recruiting

Address

Institute for Rheumatology /ID# 252335

Belgrade, Beograd, 11000

Institute for Rheumatology /ID# 252338, Belgrade, Beograd, Serbia

Status

Recruiting

Address

Institute for Rheumatology /ID# 252338

Belgrade, Beograd, 11000

Special Hospital for Rheuma /ID# 252336, Novi Sad, Vojvodina, Serbia

Status

Recruiting

Address

Special Hospital for Rheuma /ID# 252336

Novi Sad, Vojvodina, 21000

Special Hospital for Rheuma /ID# 252339, Novi Sad, Vojvodina, Serbia

Status

Recruiting

Address

Special Hospital for Rheuma /ID# 252339

Novi Sad, Vojvodina, 21000

University of Pretoria /ID# 252368, Pretoria, Gauteng, South Africa

Status

Recruiting

Address

University of Pretoria /ID# 252368

Pretoria, Gauteng, 0001

Dr Elsa van Duuren /ID# 252387, Pretoria, Gauteng, South Africa

Status

Recruiting

Address

Dr Elsa van Duuren /ID# 252387

Pretoria, Gauteng, 0002

Emmed Research cc /ID# 254317, Pretoria, Gauteng, South Africa

Status

Recruiting

Address

Emmed Research cc /ID# 254317

Pretoria, Gauteng, 0002

Dr Asokan Naidoo /ID# 252894, Umhlanga, Kwazulu-Natal, South Africa

Status

Recruiting

Address

Dr Asokan Naidoo /ID# 252894

Umhlanga, Kwazulu-Natal, 4319

Cape Town, Western Cape, South Africa

Status

Recruiting

Address

Winelands Medical Research - Somerset West /ID# 252745

Cape Town, Western Cape, 7130

Cape Town, Western Cape, South Africa

Status

Recruiting

Address

Arthritis Clinical Research Trials /ID# 252370

Cape Town, Western Cape, 7405

Stellenbosch, Western Cape, South Africa

Status

Recruiting

Address

Winelands Medical Research Centre /ID# 252369

Stellenbosch, Western Cape, 7600

Santiago de Compostela, A Coruna, Spain

Status

Recruiting

Address

Hospital Clínico Universitario de Santiago-CHUS /ID# 252430

Santiago de Compostela, A Coruna, 15706

Hospital Marina Baixa /ID# 254141, Villajoyosa, Alicante, Spain

Status

Recruiting

Address

Hospital Marina Baixa /ID# 254141

Villajoyosa, Alicante, 03570

Badalona, Barcelona, Spain

Status

Recruiting

Address

Hospital Universitario Germans Trias i Pujol /ID# 254144

Badalona, Barcelona, 08916

Sabadell, Barcelona, Spain

Status

Recruiting

Address

Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 252425

Sabadell, Barcelona, 08208

Valencia, Spain

Status

Recruiting

Address

Hospital Universitario y Politecnico La Fe /ID# 254143

Valencia, , 46026

Royal Free Hospital /ID# 252297, London, London, City Of, United Kingdom

Status

Recruiting

Address

Royal Free Hospital /ID# 252297

London, London, City Of, NW3 2QG

Kings Lynn, Norfolk, United Kingdom

Status

Recruiting

Address

The Queen Elizabeth Hospital, Kings Lynn NHS Foundation Trust /ID# 252301

Kings Lynn, Norfolk, PE30 4ET

London, United Kingdom

Status

Recruiting

Address

Queen Mary University of London /ID# 252671

London, , EC1M 6BQ

Portsmouth, United Kingdom

Status

Recruiting

Address

Portsmouth Hospitals University NHS Trust /ID# 252772

Portsmouth, , PO6 3LY