Clinical Trial Finder

Inclusion Criteria:

1. Provision of informed consent prior to any study specific procedures. 2. Female or male ≥18 years of age at the time of signing the informed consent. 3. Meet the 2019 EULAR/ACR Classification Criteria for SLE. 4. Female subjects must use 1 effective method of avoiding pregnancy, from the time they sign consent until end of the study period unless the subject is surgically sterile (e.g., bilateral oophorectomy or complete hysterectomy), has a sterile male partner, is at least 1 year postmenopausal, or practices sustained abstinence consistent with the subject's customary lifestyle. Postmenopausal is defined as at least 1 year since last menses and the subject has an elevated follicle-stimulating hormone (FSH) level greater than the threshold laboratory value of post-menopausal women at screening.

Exclusion Criteria:

1. Prior administration of the Herpes Zoster subunit vaccine (Shingrix) or the Varicella-Zoster virus vaccine live (Zostavax) 2. Clinical HZ infection within 12 months prior to screening or during screening. 3. Hybrid SLEDAI >12 at screening visit. 4. Presence of a mild, moderate, or severe flare per the rSFI at time of screenin. 5. Increase in clinical SLEDAI parameters at time of enrollment relative to screening visit. 6. Any vaccine, including the final/booster dose of any SARS-CoV-2 vaccine, within six weeks enrollment. 7. Receipt of rituximab or cyclophosphamide within nine months of enrollment. 8. Participation in an interventional clinical trial of SLE or other therapeutics within six months of enrollment. 9. Moderate to severe infectious febrile illness or use of systemic antibiotics (antibacterial, antiviral, antifungal, or antiparasitic agent) within 4 weeks of enrollment. 10. Are pregnant, nursing, or planning a pregnancy while enrolled in the study. 11. Known primary or secondary immunodeficiency (malignancy, HIV, common variable immune deficiency) or medications used during cancer chemotherapy

Arms

Experimental: HZ/su Vaccine, then Placebo

During the initial 24-week period (Period 1), participants will receive HZ/su injection at week 0 and week 8. During the second 24-week period (Period 2), participants will receive placebo saline injection at week 24 and week 32.

Experimental: Placebo, then HZ/su Vaccine

During the initial 24-week period (Period 1), participants will receive placebo saline injection at week 0 and week 8. During the second 24-week period (Period 2), participants will receive HZ/su injection at week 24 and week 32.

Interventions

Biological: - Herpes Zoster Subunit (HZ/su) Vaccine

Manufactured by GSK Biologicals SA. Administered as two-time injection of 0.5 mL each at either weeks 0 and 8 or weeks 24 and 32.

Biological: - Placebo

Saline injection. Administered as two-time injection of 0.5 mL each at either weeks 0 and 8 or weeks 24 and 32.