A Study to Assess the Efficacy and Safety of BIIB059 (Litifilimab) in Participants With Active Subacute Cutaneous Lupus Erythematosus (SCLE) and/or Chronic Cutaneous Lupus Erythematosus (CCLE) With or Without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy

Study Purpose

The primary objectives of the study are to evaluate the efficacy of BIIB059 (litifilimab) compared with placebo in reducing skin disease activity measured by the Cutaneous Lupus Activity of Physician's Global Assessment-Revised (CLA-IGA-R) score [Parts A and B (US)] and the Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity (CLASI-A) score [Part B (ROW)] in participants with active SCLE and/or CCLE with or without systemic manifestations and refractory and/or intolerant to antimalarials. The secondary objectives of the study are to evaluate the efficacy of BIIB059 in reducing SCLE and/or CCLE disease activity by CLA-IGA-R, CLASI-A; to evaluate additional efficacy parameters of BIIB059 in reducing SCLE and/or CCLE disease activity; safety; tolerability; and immunogenicity of BIIB059 [Parts A and B].

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Key

Inclusion Criteria:

1. Histologically confirmed (in the past or during the Screening period) diagnosis of CLE with or without systemic manifestations. 2. Must have active cutaneous manifestations that meet study criteria. 3. Must have a CLASI-A score ≥10. 4. Must have an active CLE lesion despite an adequate trial of antimalarial treatment. Key

Exclusion Criteria:

1. Any active skin conditions other than CLE that may interfere with the study assessments of CLE. 2. Active severe lupus nephritis. 3. Active neuropsychiatric SLE. 4. Use of intralesional corticosteroids within 1 week prior to Screening and during the study. 5. Use of immunosuppressive or disease-modifying treatments for SLE or CLE [via an oral, intravenous (IV), or SC route] that were initiated less than 12 weeks prior to randomization, have not been at a stable and allowable dose. NOTE: Other protocol defined Inclusion/Exclusion criteria may apply

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT05531565
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2/Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Biogen
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Medical Director
Principal Investigator Affiliation Biogen
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Brazil, Bulgaria, Canada, Chile, France, Germany, Hungary, Italy, Japan, Korea, Republic of, Mexico, Philippines, Poland, Portugal, Puerto Rico, Saudi Arabia, Serbia, Slovakia, Spain, Sweden, Switzerland, Taiwan, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
Additional Details

BIIB059 is a humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting blood dendritic cell antigen 2 and is being investigated for the potential treatment of systemic lupus erythematosus and cutaneous lupus erythematosus.

Arms & Interventions

Arms

Experimental: Part A (Phase 2): BIIB059

Participants will receive BIIB059 subcutaneously (SC) once every 4 weeks (Q4W) from Week 0 to Week 20, with an additional dose of BIIB059 at Week 2 during the double-blind placebo-controlled (DBPC) treatment period. Following the DBPC treatment period, participants will receive BIIB059 during the extended treatment period (ETP) from Week 24 to Week 48, with an additional dose of BIIB059-matching placebo at Week 26.

Placebo Comparator: Part A (Phase 2): Placebo

Participants will receive BIIB059-matching placebo SC Q4W from Week 0 to Week 20, with an additional dose of BIIB59-matching placebo at Week 2 during the DBPC treatment period. Following the DBPC treatment period, participants will receive BIIB059 during the ETP from Week 24 to Week 48, with an additional dose of BIIB059 at Week 26.

Experimental: Part B (Phase 3): BIIB059

Participants will receive BIIB059 SC Q4W from Week 0 to Week 20, with an additional dose of BIIB059 at Week 2 during the DBPC treatment period. Following the DBPC treatment period, participants will receive BIIB059 during the ETP from Week 24 to Week 48, with an additional dose of BIIB059-matching placebo at Week 26.

Placebo Comparator: Part B (Phase 3): Placebo

Participants will receive BIIB059-matching placebo SC Q4W from Week 0 to Week 20, with an additional dose of BIIB59-matching placebo at Week 2 during the DBPC treatment period. Following the DBPC treatment period, participants will receive BIIB059 during the ETP from Week 24 to Week 48, with an additional dose of BIIB059 at Week 26.

Interventions

Drug: - BIIB059 (litifilimab)

Administered as specified in the treatment arm.

Drug: - Placebo

Administered as specified in the treatment arm.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Pinnacle Research Group, LLC, Anniston, Alabama

Status

Recruiting

Address

Pinnacle Research Group, LLC

Anniston, Alabama, 36207

Birmingham, Alabama

Status

Recruiting

Address

UAB Center for Women's Reproductive Health

Birmingham, Alabama, 35233-7340

Phoenix, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatology Research, PLLC

Phoenix, Arizona, 85032

La Jolla, California

Status

Recruiting

Address

The Regents of the University of California

La Jolla, California, 92037

Dermatology Research Associates, Los Angeles, California

Status

Recruiting

Address

Dermatology Research Associates

Los Angeles, California, 90045

Clinical Science Institute, Santa Monica, California

Status

Recruiting

Address

Clinical Science Institute

Santa Monica, California, 90404

Upland, California

Status

Recruiting

Address

Inland Rheumatology Clinical Trials, Inc.

Upland, California, 91786

Denver Arthritis Clinic, Denver, Colorado

Status

Recruiting

Address

Denver Arthritis Clinic

Denver, Colorado, 80230

Omega Research Debary, LLC, DeBary, Florida

Status

Recruiting

Address

Omega Research Debary, LLC

DeBary, Florida, 32713

Fort Lauderdale, Florida

Status

Recruiting

Address

Centre for Rheumatology, Immunology and Arthritis

Fort Lauderdale, Florida, 33334

University of Florida, Gainesville, Florida

Status

Recruiting

Address

University of Florida

Gainesville, Florida, 32610

Charisma Medical and Research Center, Miami Lakes, Florida

Status

Recruiting

Address

Charisma Medical and Research Center

Miami Lakes, Florida, 33014

Miami, Florida

Status

Recruiting

Address

University of Miami Miller School of Medicine

Miami, Florida, 33125

Medical Research Center of Miami, Miami, Florida

Status

Completed

Address

Medical Research Center of Miami

Miami, Florida, 33134

OrthoIllinois, Rockford, Illinois

Status

Recruiting

Address

OrthoIllinois

Rockford, Illinois, 61114

Dawes Fretzin Dermatology Group, LLC, Indianapolis, Indiana

Status

Recruiting

Address

Dawes Fretzin Dermatology Group, LLC

Indianapolis, Indiana, 46250

Brigham And Women's Hospital, Boston, Massachusetts

Status

Recruiting

Address

Brigham And Women's Hospital

Boston, Massachusetts, 02115

Essential Dermatology, Natick, Massachusetts

Status

Recruiting

Address

Essential Dermatology

Natick, Massachusetts, 01760

Beacon Clinical Research, LLC, Quincy, Massachusetts

Status

Recruiting

Address

Beacon Clinical Research, LLC

Quincy, Massachusetts, 02169

University of Massachusetts, Worcester, Worcester, Massachusetts

Status

Recruiting

Address

University of Massachusetts, Worcester

Worcester, Massachusetts, 01655

David Fivenson, MD, Dermatology, PLLC, Ann Arbor, Michigan

Status

Recruiting

Address

David Fivenson, MD, Dermatology, PLLC

Ann Arbor, Michigan, 48103

Oakland Hills Dermatology, Auburn Hills, Michigan

Status

Recruiting

Address

Oakland Hills Dermatology

Auburn Hills, Michigan, 48326

Grand Blanc, Michigan

Status

Recruiting

Address

AA MRC LLC Ahmed Arif Medical Research Center

Grand Blanc, Michigan, 48504

Revival Research Institute, LLC, Troy, Michigan

Status

Recruiting

Address

Revival Research Institute, LLC

Troy, Michigan, 48084

Saint Louis University, Saint Louis, Missouri

Status

Recruiting

Address

Saint Louis University

Saint Louis, Missouri, 63110

University of Nebraska Medical Center, Omaha, Nebraska

Status

Recruiting

Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Albuquerque Center For Rheumatology, Albuquerque, New Mexico

Status

Recruiting

Address

Albuquerque Center For Rheumatology

Albuquerque, New Mexico, 87102

Albuquerque, New Mexico

Status

Recruiting

Address

University of New Mexico School of Medicine

Albuquerque, New Mexico, 87106

NYU Langone Brooklyn, Brooklyn, New York

Status

Recruiting

Address

NYU Langone Brooklyn

Brooklyn, New York, 11220

Universal Dermatology, PLLC, Fairport, New York

Status

Recruiting

Address

Universal Dermatology, PLLC

Fairport, New York, 14450

Northwell Health, Inc. PRIME, Great Neck, New York

Status

Recruiting

Address

Northwell Health, Inc. PRIME

Great Neck, New York, 11021

Columbia University Medical center, New York, New York

Status

Recruiting

Address

Columbia University Medical center

New York, New York, 10032

Chapel Hill, North Carolina

Status

Recruiting

Address

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27514

Duke Dermatology South Durham, Durham, North Carolina

Status

Recruiting

Address

Duke Dermatology South Durham

Durham, North Carolina, 27710

Medication Management, LLC, Greensboro, North Carolina

Status

Completed

Address

Medication Management, LLC

Greensboro, North Carolina, 27405

Cincinnati, Ohio

Status

Recruiting

Address

University of Cincinnati Department of Dermatology

Cincinnati, Ohio, 45219

Cleveland, Ohio

Status

Recruiting

Address

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106

Ohio State University, Columbus, Ohio

Status

Recruiting

Address

Ohio State University

Columbus, Ohio, 43210

Hershey, Pennsylvania

Status

Recruiting

Address

Penn State University Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033

University of Pennsylvania, Philadelphia, Pennsylvania

Status

Recruiting

Address

University of Pennsylvania

Philadelphia, Pennsylvania, 19104

Vanderbilt University Medical Center, Nashville, Tennessee

Status

Recruiting

Address

Vanderbilt University Medical Center

Nashville, Tennessee, 37232

Austin Regional Clinic, P.A., Austin, Texas

Status

Recruiting

Address

Austin Regional Clinic, P.A.

Austin, Texas, 78731

Colleyville, Texas

Status

Recruiting

Address

Precision Comprehensive Clinical Research Solutions

Colleyville, Texas, 76034

Metroplex Clinical Research Center, LLC, Dallas, Texas

Status

Completed

Address

Metroplex Clinical Research Center, LLC

Dallas, Texas, 75231

UT Southwestern Medical Center, Dallas, Texas

Status

Recruiting

Address

UT Southwestern Medical Center

Dallas, Texas, 75390-8896

North Texas Center for Clinical Research, Frisco, Texas

Status

Recruiting

Address

North Texas Center for Clinical Research

Frisco, Texas, 75034

UTMB Department of Dermatology, Galveston, Texas

Status

Recruiting

Address

UTMB Department of Dermatology

Galveston, Texas, 77555-0583

Arthritis & Osteoporosis Clinic, Waco, Texas

Status

Recruiting

Address

Arthritis & Osteoporosis Clinic

Waco, Texas, 76710

Salt Lake City, Utah

Status

Recruiting

Address

University of Utah Health Sciences Center

Salt Lake City, Utah, 84132

West End Dermatology Associates, Richmond, Virginia

Status

Recruiting

Address

West End Dermatology Associates

Richmond, Virginia, 23233

International Sites

Ciudad Autonoma de Buenos Aire, Buenos Aires, Argentina

Status

Recruiting

Address

CINME - Centro De Investigaciones Metabolicas

Ciudad Autonoma de Buenos Aire, Buenos Aires, C1056ABJ

Mar del Plata, Buenos Aires, Argentina

Status

Recruiting

Address

Centro de Investigaciones Medicas Mar del Plata

Mar del Plata, Buenos Aires, 7600

Quilmes, Buenos Aires, Argentina

Status

Recruiting

Address

Instituto de Investigaciones Clinicas Quilmes

Quilmes, Buenos Aires, B1878GEG

APRILLUS Asistencia e Investigacion, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina

Status

Recruiting

Address

APRILLUS Asistencia e Investigacion

Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires, C1406AGA

Fundacion Respirar, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina

Status

Recruiting

Address

Fundacion Respirar

Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires, C1426ABO

Instituto CAICI, Rosario, Santa Fe, Argentina

Status

Recruiting

Address

Instituto CAICI

Rosario, Santa Fe, S2000PBJ

San Miguel de Tucuman, Tucuman, Argentina

Status

Recruiting

Address

Clinica Mayo de Urgencias Medicas Cruz Blanca SRL

San Miguel de Tucuman, Tucuman, 4000

San Miguel de Tucuman, Tucuman, Argentina

Status

Recruiting

Address

Centro de Investigaciones Medicas Tucuman

San Miguel de Tucuman, Tucuman, T4000AXL

Investigaciones Clinicas Tucuman, San Miguel de Tucuman, Tucuman, Argentina

Status

Recruiting

Address

Investigaciones Clinicas Tucuman

San Miguel de Tucuman, Tucuman, T4000ICL

Hospital Italiano de La Plata, Buenos Aires, Argentina

Status

Recruiting

Address

Hospital Italiano de La Plata

Buenos Aires, , B1900AXI

Ciudad Autonoma Buenos Aires, Argentina

Status

Recruiting

Address

Centro Privado de Medicina Familiar - Mind Out Research

Ciudad Autonoma Buenos Aires, , C1417

Clinica Adventista Belgrano, Ciudad Autonoma Buenos Aires, Argentina

Status

Recruiting

Address

Clinica Adventista Belgrano

Ciudad Autonoma Buenos Aires, , C1430EGF

Instituto de Reumatologia, Mendoza, Argentina

Status

Recruiting

Address

Instituto de Reumatologia

Mendoza, , M5500

San Juan, Argentina

Status

Recruiting

Address

CER San Juan Centro Polivalente de Asistencia e Inv. Clinica

San Juan, , 5400

Clínica SER da Bahia, Salvador, Bahia, Brazil

Status

Recruiting

Address

Clínica SER da Bahia

Salvador, Bahia, 40150-150

Fortaleza, Ceará, Brazil

Status

Recruiting

Address

HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará

Fortaleza, Ceará, 60430-370

Brasilia, Distrito Federal, Brazil

Status

Recruiting

Address

L2IP - Instituto de Pesquisas Clínicas Ltda.

Brasilia, Distrito Federal, 70200-730

CEDOES - Diagnóstico e Pesquisa, Vitória, Espírito Santo, Brazil

Status

Recruiting

Address

CEDOES - Diagnóstico e Pesquisa

Vitória, Espírito Santo, 29055-450

Santo Ângelo, Mato Grosso, Brazil

Status

Recruiting

Address

IPC MT Instituto de Pesquisas Clinicas do Mato Grosso

Santo Ângelo, Mato Grosso, 78020-500

CMiP - Centro Mineiro de Pesquisa, Juiz de Fora, Minas Gerais, Brazil

Status

Recruiting

Address

CMiP - Centro Mineiro de Pesquisa

Juiz de Fora, Minas Gerais, 36010-570

Rio de Janeiro, Rio Do Janeiro, Brazil

Status

Recruiting

Address

Instituto Brasil de Pesquisa Clínica-IBPCLIN S/A

Rio de Janeiro, Rio Do Janeiro, 20241-180

Rio de Janeiro, Rio Do Janeiro, Brazil

Status

Recruiting

Address

IDERJ - Instituto de Dermatologia e Estética do Brasil Ltda

Rio de Janeiro, Rio Do Janeiro, 22470-220

Hospital Bruno Born, Lajeado, Rio Grande Do Sul, Brazil

Status

Recruiting

Address

Hospital Bruno Born

Lajeado, Rio Grande Do Sul, 95900-000

Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul, Brazil

Status

Recruiting

Address

Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande Do Sul, 90035-903

Porto Alegre, Rio Grande Do Sul, Brazil

Status

Recruiting

Address

Nucleo de Pesquisa Clinica do Rio Grande do Sul

Porto Alegre, Rio Grande Do Sul, 90430001

LMK Serviços Médicos S/S Ltda, Porto Alegre, Rio Grande Do Sul, Brazil

Status

Recruiting

Address

LMK Serviços Médicos S/S Ltda

Porto Alegre, Rio Grande Do Sul, 90480-000

Sao Bernardo Do Campo, Sao Paulo, Brazil

Status

Recruiting

Address

CEMEC - Centro Multidisciplinar de Estudos Clínicos

Sao Bernardo Do Campo, Sao Paulo, 09715-090

São Paulo, Sao Paulo, Brazil

Status

Recruiting

Address

CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos

São Paulo, Sao Paulo, 04266-010

Medical center Medconsult Pleven OOD, Pleven, Bulgaria

Status

Recruiting

Address

Medical center Medconsult Pleven OOD

Pleven, , 5800

UMHAT 'Dr. Georgi Stranski', EAD, Pleven, Bulgaria

Status

Recruiting

Address

UMHAT 'Dr. Georgi Stranski', EAD

Pleven, , 5800

DCC 1 - Ruse, EOOD, Ruse, Bulgaria

Status

Recruiting

Address

DCC 1 - Ruse, EOOD

Ruse, , 7002

DCC 'Alexandrovska', EOOD, Sofia, Bulgaria

Status

Recruiting

Address

DCC 'Alexandrovska', EOOD

Sofia, , 1431

DCC Focus 5 - MEOH OOD, Sofia, Bulgaria

Status

Recruiting

Address

DCC Focus 5 - MEOH OOD

Sofia, , 1463

DCC Focus 5 - MEOH OOD, Sofia, Bulgaria

Status

Recruiting

Address

DCC Focus 5 - MEOH OOD

Sofia, , 1463

Military Medical Academy - MHAT - Sofia, Sofia, Bulgaria

Status

Recruiting

Address

Military Medical Academy - MHAT - Sofia

Sofia, , 1606

Laser Rejuvenation Clinics, Inc., Calgary, Alberta, Canada

Status

Recruiting

Address

Laser Rejuvenation Clinics, Inc.

Calgary, Alberta, T2W 4X9

Edmonton, Alberta, Canada

Status

Recruiting

Address

Laster Rejuvenation Clinics Edmonton D.T. Inc.

Edmonton, Alberta, T5J 3S9

Dermatology Ottawa Research Centre, Ottawa, Ontario, Canada

Status

Recruiting

Address

Dermatology Ottawa Research Centre

Ottawa, Ontario, K2C 3N2

Medicor Research Inc, Sudbury, Ontario, Canada

Status

Completed

Address

Medicor Research Inc

Sudbury, Ontario, P3C 1X3

DIEX Recherche Sherbrooke Inc., Sherbrooke, Quebec, Canada

Status

Recruiting

Address

DIEX Recherche Sherbrooke Inc.

Sherbrooke, Quebec, J1L 0H8

Centro Medico SkinMed, Las Condes, Chile

Status

Recruiting

Address

Centro Medico SkinMed

Las Condes, , 7580206

Dermacross, Santiago, Chile

Status

Recruiting

Address

Dermacross

Santiago, , 66901

BioMedica Research Group, Santiago, Chile

Status

Recruiting

Address

BioMedica Research Group

Santiago, , 7500710

CeCim Biocinetic, Santiago, Chile

Status

Recruiting

Address

CeCim Biocinetic

Santiago, , 8331143

Santiago, Chile

Status

Recruiting

Address

CIEC - Centro Internacional de Estudios Clínicos

Santiago, , 8420383

Clinical Research Chile SpA., Valdivia, Chile

Status

Recruiting

Address

Clinical Research Chile SpA.

Valdivia, , 5090000

Oncocentro APYS, Viña del Mar, Chile

Status

Recruiting

Address

Oncocentro APYS

Viña del Mar, , 2520598

CHU Nice - Hopital de l Archet, Nice cedex 3, Alpes Maritimes, France

Status

Recruiting

Address

CHU Nice - Hopital de l Archet

Nice cedex 3, Alpes Maritimes, 6200

Hôpital de la Timone, Marseille cedex 5, Bouches-du-Rhône, France

Status

Recruiting

Address

Hôpital de la Timone

Marseille cedex 5, Bouches-du-Rhône, 13385

Caen, Calvados, France

Status

Recruiting

Address

CHU de Caen - Hopital de la Cote de Nacre

Caen, Calvados, 14033

CHU Besançon - Hôpital Jean Minjoz, Besançon Cedex, Doubs, France

Status

Recruiting

Address

CHU Besançon - Hôpital Jean Minjoz

Besançon Cedex, Doubs, 25030

Hopital Larrey, Toulouse Cedex 9, Haute Garonne, France

Status

Recruiting

Address

Hopital Larrey

Toulouse Cedex 9, Haute Garonne, 31059

Hôpital Privé d'Antony, Antony, Hauts De Seine, France

Status

Recruiting

Address

Hôpital Privé d'Antony

Antony, Hauts De Seine, 92160

Hopital Saint Eloi, Montpellier Cedex 5, Herault, France

Status

Recruiting

Address

Hopital Saint Eloi

Montpellier Cedex 5, Herault, 34295

Hôpital Saint-Louis, Cedex 10, Paris, France

Status

Recruiting

Address

Hôpital Saint-Louis

Cedex 10, Paris, 75475

Hopital Edouard Herriot - CHU Lyon, Lyon, Rhone, France

Status

Recruiting

Address

Hopital Edouard Herriot - CHU Lyon

Lyon, Rhone, 69003

Hopital Tenon, Paris, France

Status

Recruiting

Address

Hopital Tenon

Paris, , 75020

Universitaetsklinikum Heidelberg, Heidelberg, Baden Wuerttemberg, Germany

Status

Recruiting

Address

Universitaetsklinikum Heidelberg

Heidelberg, Baden Wuerttemberg, 69120

Universitaetsklinikum Erlangen, Erlangen, Bayern, Germany

Status

Recruiting

Address

Universitaetsklinikum Erlangen

Erlangen, Bayern, 91054

Fachklinik Bad Bentheim Dermatologie, Bad Bentheim, Niedersachsen, Germany

Status

Recruiting

Address

Fachklinik Bad Bentheim Dermatologie

Bad Bentheim, Niedersachsen, 48455

Elbekliniken Buxtehude GmbH, Buxtehude, Niedersachsen, Germany

Status

Recruiting

Address

Elbekliniken Buxtehude GmbH

Buxtehude, Niedersachsen, 21614

Klinikum Oldenburg AoeR, Oldenburg, Niedersachsen, Germany

Status

Recruiting

Address

Klinikum Oldenburg AoeR

Oldenburg, Niedersachsen, 26133

Universitaetsklinikum Bonn AoeR, Bonn, Nordrhein Westfalen, Germany

Status

Recruiting

Address

Universitaetsklinikum Bonn AoeR

Bonn, Nordrhein Westfalen, 53127

Universitaetsklinikum Muenster, Muenster, Nordrhein Westfalen, Germany

Status

Recruiting

Address

Universitaetsklinikum Muenster

Muenster, Nordrhein Westfalen, 48149

Universitaetsklinikum Halle (Saale), Halle, Sachsen Anhalt, Germany

Status

Recruiting

Address

Universitaetsklinikum Halle (Saale)

Halle, Sachsen Anhalt, 6120

Dresden, Sachsen, Germany

Status

Recruiting

Address

Universitaetsklinikum Carl Gustav Carus TU Dresden

Dresden, Sachsen, 1307

Kiel, Schleswig Holstein, Germany

Status

Recruiting

Address

Universitaetsklinikum Schleswig-Holstein - Campus Kiel

Kiel, Schleswig Holstein, 24105

Charité - Campus Charité Mitte, Berlin, Germany

Status

Recruiting

Address

Charité - Campus Charité Mitte

Berlin, , 10117

Pecsi Tudomanyegyetem, Pecs, Hungary

Status

Recruiting

Address

Pecsi Tudomanyegyetem

Pecs, , 7632

Bologna, Italy

Status

Recruiting

Address

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS

Bologna, , 40138

Brescia, Italy

Status

Recruiting

Address

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)

Brescia, , 25123

Università degli studi di Firenze, Firenze, Italy

Status

Recruiting

Address

Università degli studi di Firenze

Firenze, , 50121

IRCCS Ospedale Policlinico San Martino, Genova, Italy

Status

Recruiting

Address

IRCCS Ospedale Policlinico San Martino

Genova, , 16132

Milano, Italy

Status

Recruiting

Address

Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico

Milano, , 20122

Ospedale San Raffaele, Milano, Italy

Status

Recruiting

Address

Ospedale San Raffaele

Milano, , 20132

Napoli, Italy

Status

Recruiting

Address

Azienda Ospedaliera Universitaria Policlinico 'Federico II'

Napoli, , 80131

Roma, Italy

Status

Recruiting

Address

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, , 137

JCHO Chukyo Hospital, Nagoya-shi, Aichi-Ken, Japan

Status

Recruiting

Address

JCHO Chukyo Hospital

Nagoya-shi, Aichi-Ken, 457-8510

NHO Nagoya Medical Center, Nagoya-shi, Aichi-Ken, Japan

Status

Recruiting

Address

NHO Nagoya Medical Center

Nagoya-shi, Aichi-Ken, 460-0001

Aomori Prefectural Central Hospital, Aomori-shi, Aomori-Ken, Japan

Status

Recruiting

Address

Aomori Prefectural Central Hospital

Aomori-shi, Aomori-Ken, 030-8553

Juntendo University Urayasu Hospital, Urayasu-shi, Chiba-Ken, Japan

Status

Recruiting

Address

Juntendo University Urayasu Hospital

Urayasu-shi, Chiba-Ken, 279-0021

University of Fukui Hospital, Yoshida-gun, Fukui-Ken, Japan

Status

Recruiting

Address

University of Fukui Hospital

Yoshida-gun, Fukui-Ken, 910-1193

Kitakyushu-shi, Fukuoka-Ken, Japan

Status

Recruiting

Address

Hospital of the University of Occupational and Environmental Health

Kitakyushu-shi, Fukuoka-Ken, 807-8556

Kakogawa Central City Hospital, Kakogawa-shi, Hyogo-Ken, Japan

Status

Recruiting

Address

Kakogawa Central City Hospital

Kakogawa-shi, Hyogo-Ken, 675-8611

Kita Harima Medical Center, Ono-shi, Hyogo-Ken, Japan

Status

Recruiting

Address

Kita Harima Medical Center

Ono-shi, Hyogo-Ken, 675-1392

Kanazawa University Hospital, Kanazawa-shi, Ishikawa-Ken, Japan

Status

Recruiting

Address

Kanazawa University Hospital

Kanazawa-shi, Ishikawa-Ken, 920-8641

St. Marianna University Hospital, Kawasaki-shi, Kanagawa-Ken, Japan

Status

Recruiting

Address

St. Marianna University Hospital

Kawasaki-shi, Kanagawa-Ken, 216-8511

Yokohama City University Hospital, Yokohama-shi, Kanagawa-Ken, Japan

Status

Recruiting

Address

Yokohama City University Hospital

Yokohama-shi, Kanagawa-Ken, 236-0004

NHO Yokohama Medical Center, Yokohama-shi, Kanagawa-Ken, Japan

Status

Recruiting

Address

NHO Yokohama Medical Center

Yokohama-shi, Kanagawa-Ken, 245-8575

Kumamoto University Hospital, Kumamoto-shi, Kumamoto-Ken, Japan

Status

Recruiting

Address

Kumamoto University Hospital

Kumamoto-shi, Kumamoto-Ken, 860-8556

Tohoku University Hospital, Sendai-shi, Miyagi-Ken, Japan

Status

Recruiting

Address

Tohoku University Hospital

Sendai-shi, Miyagi-Ken, 980-8574

Nagasaki University Hospital, Nagasaki-Shi, Nagasaki-Ken, Japan

Status

Recruiting

Address

Nagasaki University Hospital

Nagasaki-Shi, Nagasaki-Ken, 852-8501

Niigata-shi, Niigata-Ken, Japan

Status

Recruiting

Address

Niigata University Medical & Dental Hospital

Niigata-shi, Niigata-Ken, 951-8520

Japanese Red Cross Okayama Hospital, Okayama-shi, Okayama-Ken, Japan

Status

Recruiting

Address

Japanese Red Cross Okayama Hospital

Okayama-shi, Okayama-Ken, 700-8607

NHO Osaka Minami Medical Center, Kawachinagano-shi, Osaka-Fu, Japan

Status

Recruiting

Address

NHO Osaka Minami Medical Center

Kawachinagano-shi, Osaka-Fu, 586-8521

Daini Osaka Police Hospital, Osaka-shi, Osaka-Fu, Japan

Status

Recruiting

Address

Daini Osaka Police Hospital

Osaka-shi, Osaka-Fu, 543-8922

Kindai University Hospital, Osakasayama-shi, Osaka-Fu, Japan

Status

Recruiting

Address

Kindai University Hospital

Osakasayama-shi, Osaka-Fu, 589-8511

Osaka University Hospital, Suita-shi, Osaka-Fu, Japan

Status

Recruiting

Address

Osaka University Hospital

Suita-shi, Osaka-Fu, 565-0871

Takatsuki Red Cross Hospital, Takatsuki-shi, Osaka-Fu, Japan

Status

Recruiting

Address

Takatsuki Red Cross Hospital

Takatsuki-shi, Osaka-Fu, 569-1096

Otsu-shi, Shiga-Ken, Japan

Status

Recruiting

Address

Shiga University of Medical Science Hospital

Otsu-shi, Shiga-Ken, 520-2192

Shimane University Hospital, Izumo-shi, Shimane-Ken, Japan

Status

Recruiting

Address

Shimane University Hospital

Izumo-shi, Shimane-Ken, 693-8501

Teikyo University Hospital, Itabashi-ku, Tokyo-To, Japan

Status

Recruiting

Address

Teikyo University Hospital

Itabashi-ku, Tokyo-To, 173-8606

Showa University East Hospital, Shinagawa-ku, Tokyo-To, Japan

Status

Recruiting

Address

Showa University East Hospital

Shinagawa-ku, Tokyo-To, 142-0054

Wakayama Medical University Hospital, Wakayama-shi, Wakayama-Ken, Japan

Status

Recruiting

Address

Wakayama Medical University Hospital

Wakayama-shi, Wakayama-Ken, 641-8510

Korea University Ansan Hospital, Ansan-si, Gyeonggi-do, Korea, Republic of

Status

Recruiting

Address

Korea University Ansan Hospital

Ansan-si, Gyeonggi-do, 15355

Ajou University Hospital, Suwon, Gyeonggi-do, Korea, Republic of

Status

Recruiting

Address

Ajou University Hospital

Suwon, Gyeonggi-do, 16499

Chonnam National University Hospital, Gwangju, Korea, Republic of

Status

Recruiting

Address

Chonnam National University Hospital

Gwangju, , 61469

Seoul, Korea, Republic of

Status

Recruiting

Address

Severance Hospital, Yonsei University Health System

Seoul, , 3722

Hanyang University Seoul Hospital, Seoul, Korea, Republic of

Status

Recruiting

Address

Hanyang University Seoul Hospital

Seoul, , 4763

Seoul, Korea, Republic of

Status

Recruiting

Address

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, , 6591

Clinstile, S.A. de C.V., Ciudad de México, Distrito Federal, Mexico

Status

Recruiting

Address

Clinstile, S.A. de C.V.

Ciudad de México, Distrito Federal, 6700

Mexico, Distrito Federal, Mexico

Status

Recruiting

Address

Centro de Investigacion Clínica GRAMEL S.C

Mexico, Distrito Federal, 3720

Guadalajara, Jalisco, Mexico

Status

Recruiting

Address

Centro de investigacion medica y reumatologia

Guadalajara, Jalisco, 44959

Cuernavaca, Morelos, Mexico

Status

Recruiting

Address

Consultorio Privado Dr. Miguel Cortes Hernandez

Cuernavaca, Morelos, 62448

Medical Care & Research SA de CV, Merida, Yucatán, Mexico

Status

Recruiting

Address

Medical Care & Research SA de CV

Merida, Yucatán, 97070

Derma Norte del Bajio S.C., Aguascalientes, Mexico

Status

Recruiting

Address

Derma Norte del Bajio S.C.

Aguascalientes, , 20127

Chihuahua, Mexico

Status

Recruiting

Address

Investigacion y Biomedicina de Chihuahua, S.C.

Chihuahua, , 31000

The Medical City Clark, Mabalacat, Pampanga, Philippines

Status

Recruiting

Address

The Medical City Clark

Mabalacat, Pampanga, 2023

Cebu Doctors University Hospital, Cebu City, Philippines

Status

Recruiting

Address

Cebu Doctors University Hospital

Cebu City, , 6000

Mary Mediatrix Medical Center, Lipa City, Philippines

Status

Recruiting

Address

Mary Mediatrix Medical Center

Lipa City, , 4217

Medical Center Manila, Manila, Philippines

Status

Recruiting

Address

Medical Center Manila

Manila, , 1000

Philippine General Hospital, Manila, Philippines

Status

Recruiting

Address

Philippine General Hospital

Manila, , 1000

Jose R. Reyes Memorial Medical Center, Manila, Philippines

Status

Recruiting

Address

Jose R. Reyes Memorial Medical Center

Manila, , 1012

Quezon City, Metro Manila, Philippines

Status

Recruiting

Address

Far Eastern University - Dr. Nicanor Reyes Medical Foundation

Quezon City, Metro Manila, , 1118

St. Luke's Medical Center, Quezon City, Philippines

Status

Recruiting

Address

St. Luke's Medical Center

Quezon City, , 1102

San Fenando, La Union, Philippines

Status

Recruiting

Address

Ilocos Training and Regional Medical Center

San Fenando, La Union, , 2500

Krakow, Poland

Status

Recruiting

Address

Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski

Krakow, , 31-530

SPZOZ Szpital Uniwersytecki w Krakowie, Kraków, Poland

Status

Recruiting

Address

SPZOZ Szpital Uniwersytecki w Krakowie

Kraków, , 31-501

Lodz, Poland

Status

Recruiting

Address

Dermoklinika Centrum Medyczne SC M Kierstan J Narbutt A Lesiak

Lodz, , 90-436

Rzeszow, Poland

Status

Recruiting

Address

Kliniczny Szpital Wojewodzki nr 1 im.F.Chopina

Rzeszow, , 35-055

Szpital Kliniczny Dzieciatka Jezus, Warszawa, Poland

Status

Recruiting

Address

Szpital Kliniczny Dzieciatka Jezus

Warszawa, , 02-008

Royalderm, Warszawa, Poland

Status

Recruiting

Address

Royalderm

Warszawa, , 02-962

Wroclaw, Poland

Status

Recruiting

Address

Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska

Wroclaw, , 50-566

Coimbra, Portugal

Status

Recruiting

Address

Centro Hospitalar e Universitário de Coimbra, E.P.E (HUC)

Coimbra, , 3000-075

Hospital de Egas Moniz, Lisboa, Portugal

Status

Recruiting

Address

Hospital de Egas Moniz

Lisboa, , 1349-019

Hospital CUF Descobertas, Lisboa, Portugal

Status

Recruiting

Address

Hospital CUF Descobertas

Lisboa, , 1998-018

Porto, Portugal

Status

Recruiting

Address

Centro Hospitalar Universitártio do Porto, E.P.E.

Porto, , 4099-001

Viana do Castelo, Portugal

Status

Recruiting

Address

Unidade Local de Saúde do Alto Minho, E.P.E.

Viana do Castelo, , 4904-858

Dr. Samuel Sanchez PSC, Caguas, Puerto Rico

Status

Recruiting

Address

Dr. Samuel Sanchez PSC

Caguas, , 00727

GCM Medical Group PSC - Hato Rey, San Juan, Puerto Rico

Status

Recruiting

Address

GCM Medical Group PSC - Hato Rey

San Juan, , 917

Riyadh, Saudi Arabia

Status

Recruiting

Address

King Faisal Specialist Hospital & Research Center

Riyadh, , 11211

King Saud University, Riyadh, Saudi Arabia

Status

Recruiting

Address

King Saud University

Riyadh, , 11461

Institute of Rheumatology, Belgrade, Serbia

Status

Recruiting

Address

Institute of Rheumatology

Belgrade, , 11000

University Clinical Center of Serbia, Belgrade, Serbia

Status

Recruiting

Address

University Clinical Center of Serbia

Belgrade, , 11000

Clinical Center of Vojvodina, Novi Sad, Serbia

Status

Recruiting

Address

Clinical Center of Vojvodina

Novi Sad, , 21000

Artromac n.o., Kosice, Slovakia

Status

Recruiting

Address

Artromac n.o.

Kosice, , 4011

Narodny ustav reumatickych chorob, Piestany, Slovakia

Status

Recruiting

Address

Narodny ustav reumatickych chorob

Piestany, , 92112

Badalona, Barcelona, Spain

Status

Recruiting

Address

Hospital Universitari Germans Trias i Pujol

Badalona, Barcelona, 8916

Hospital Universitario Rio Hortega, Valladolid, Cantabria, Spain

Status

Recruiting

Address

Hospital Universitario Rio Hortega

Valladolid, Cantabria, 47012

Alcorcón, Madrid, Spain

Status

Recruiting

Address

Hospital Universitario Fundacion Alcorcon

Alcorcón, Madrid, 28922

Majadahonda, Madrid, Spain

Status

Recruiting

Address

Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid, 28222

Hospital del Mar, Barcelona, Spain

Status

Recruiting

Address

Hospital del Mar

Barcelona, , 8003

Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Status

Recruiting

Address

Hospital de la Santa Creu i Sant Pau

Barcelona, , 8041

Hospital Universitario Reina Sofia, Cordoba, Spain

Status

Recruiting

Address

Hospital Universitario Reina Sofia

Cordoba, , 14004

La Coruña, Spain

Status

Recruiting

Address

Complejo Hospitalario Universitario A Coruña

La Coruña, , 15006

Hospital Universitario Virgen del Rocio, Sevilla, Spain

Status

Recruiting

Address

Hospital Universitario Virgen del Rocio

Sevilla, , 41013

Karolinska Universitetssjukhuset - Solna, Stockholm, Sweden

Status

Recruiting

Address

Karolinska Universitetssjukhuset - Solna

Stockholm, , 17176

Lausanne, Switzerland

Status

Recruiting

Address

Centre Hospitalier Universitaire Vaudois (CHUV)

Lausanne, , CH-1011

Kantonsspital St. Gallen, St. Gallen, Switzerland

Status

Recruiting

Address

Kantonsspital St. Gallen

St. Gallen, , 9007

Changhua, Taiwan

Status

Recruiting

Address

Changhua Christian Medical Foundation Changhua Christian Hospital

Changhua, , 50006

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Status

Recruiting

Address

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung, , 833

Taichung Veterans General Hospital, Taichung, Taiwan

Status

Recruiting

Address

Taichung Veterans General Hospital

Taichung, , 40705

Taipei Veterans General Hospital, Taipei, Taiwan

Status

Recruiting

Address

Taipei Veterans General Hospital

Taipei, , 11217

Whipps Cross University Hospital, London, Greater London, United Kingdom

Status

Recruiting

Address

Whipps Cross University Hospital

London, Greater London, E11 1NR

Manchester Royal Infirmary, Manchester, Greater Manchester, United Kingdom

Status

Recruiting

Address

Manchester Royal Infirmary

Manchester, Greater Manchester, M13 9WL

Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom

Status

Recruiting

Address

Queen Elizabeth Hospital

Birmingham, West Midlands, B15 2GW

Chapel Allerton Hospital, Leeds, West Yorkshire, United Kingdom

Status

Recruiting

Address

Chapel Allerton Hospital

Leeds, West Yorkshire, LS9 7TF