In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE). The study will focus on participants who have either active subacute CLE or chronic CLE, or both. They may also have systemic lupus erythematosus (SLE). The participants did not respond to antimalarial therapy or had problems with the treatment that made it hard to continue. The main objective of the study is to learn about the effect litifilimab has on lowering the activity of the skin disease. Researchers will measure symptoms of CLE over time using a variety of scoring tools. These include the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI), the Cutaneous Lupus Activity of Investigator's Global Assessment-Revised (CLA-IGA-R), and the SELENA-SLEDAI Flare Index (SFI). The main questions researchers want to answer are:
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
Eligible Ages | 18 Years and Over |
Gender | All |
Key
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT05531565 |
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2/Phase 3 |
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Biogen |
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Medical Director |
Principal Investigator Affiliation | Biogen |
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry |
Overall Status | Recruiting |
Countries | Argentina, Brazil, Bulgaria, Canada, Chile, China, Colombia, France, Germany, Hungary, Italy, Japan, Mexico, Peru, Philippines, Poland, Portugal, Puerto Rico, Saudi Arabia, Serbia, Slovakia, South Korea, Spain, Sweden, Switzerland, Taiwan, United Kingdom, United States |
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus |
Litifilimab is a humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting blood dendritic cell antigen 2 and is being investigated for the potential treatment of systemic lupus erythematosus and cutaneous lupus erythematosus. The primary objectives of the study are to evaluate the efficacy of litifilimab compared with placebo in reducing skin disease activity measured by the CLA-IGA-R score [Parts A and B (US)] and the Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity (CLASI-A) score [Part B (ROW)] in participants with active SCLE and/or CCLE with or without systemic manifestations and refractory and/or intolerant to antimalarials. The secondary objectives of the study are to evaluate the efficacy of litifilimab in reducing SCLE and/or CCLE disease activity by CLA-IGA-R, CLASI-A; to evaluate additional efficacy parameters of litifilimab in reducing SCLE and/or CCLE disease activity; safety; tolerability; and immunogenicity of litifilimab [Parts A and B].
Experimental: Part A (Phase 2): Litifilimab
Participants will receive litifilimab subcutaneously (SC) once every 4 weeks (Q4W) from Week 0 to Week 20, with an additional dose of litifilimab at Week 2 during the double-blind placebo-controlled (DBPC) treatment period. Following the DBPC treatment period, participants will receive litifilimab during the extended treatment period (ETP) from Week 24 to Week 48, with an additional dose of litifilimab-matching placebo at Week 26.
Placebo Comparator: Part A (Phase 2): Placebo
Participants will receive litifilimab-matching placebo SC Q4W from Week 0 to Week 20, with an additional dose of litifilimab-matching placebo at Week 2 during the DBPC treatment period. Following the DBPC treatment period, participants will receive litifilimab during the ETP from Week 24 to Week 48, with an additional dose of litifilimab at Week 26.
Experimental: Part B (Phase 3): Litifilimab
Participants will receive litifilimab SC Q4W from Week 0 to Week 20, with an additional dose of litifilimab at Week 2 during the DBPC treatment period. Following the DBPC treatment period, participants will receive litifilimab during the ETP from Week 24 to Week 48, with an additional dose of litifilimab-matching placebo at Week 26.
Placebo Comparator: Part B (Phase 3): Placebo
Participants will receive litifilimab-matching placebo SC Q4W from Week 0 to Week 20, with an additional dose of litifilimab-matching placebo at Week 2 during the DBPC treatment period. Following the DBPC treatment period, participants will receive litifilimab during the ETP from Week 24 to Week 48, with an additional dose of litifilimab at Week 26.
Drug: - Litifilimab
Administered as specified in the treatment arm.
Drug: - Placebo
Administered as specified in the treatment arm.
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Recruiting
Address
Pinnacle Research Group, LLC
Anniston 4830198, Alabama 4829764, 36207
Status
Recruiting
Address
UAB Center for Women's Reproductive Health
Birmingham 4049979, Alabama 4829764, 35233-7340
Status
Recruiting
Address
Arizona Arthritis & Rheumatology Research, PLLC
Phoenix 5308655, Arizona 5551752, 85032
Status
Recruiting
Address
The Regents of the University of California
La Jolla 5363943, California 5332921, 92037
Status
Recruiting
Address
Dermatology Research Associates
Los Angeles 5368361, California 5332921, 90045
Status
Completed
Address
Clinical Science Institute
Santa Monica 5393212, California 5332921, 90404
Status
Recruiting
Address
Inland Rheumatology Clinical Trials, Inc.
Upland 5404915, California 5332921, 91786
Status
Completed
Address
Denver Arthritis Clinic
Denver 5419384, Colorado 5417618, 80230
Status
Recruiting
Address
Omega Research Debary, LLC
DeBary 4152926, Florida 4155751, 32713
Status
Completed
Address
Centre for Rheumatology, Immunology and Arthritis
Fort Lauderdale 4155966, Florida 4155751, 33334
Status
Recruiting
Address
University of Florida
Gainesville 4156404, Florida 4155751, 32610
Status
Recruiting
Address
University of Miami Miller School of Medicine
Miami 4164138, Florida 4155751, 33125
Status
Completed
Address
Medical Research Center of Miami
Miami 4164138, Florida 4155751, 33134
Status
Recruiting
Address
Charisma Medical and Research Center
Miami Lakes 4164186, Florida 4155751, 33014
Status
Recruiting
Address
Augusta University
Augusta 4180531, Georgia 4197000, 30912
Status
Recruiting
Address
Rush University Medical Center
Chicago 4887398, Illinois 4896861, 60612
Status
Completed
Address
OrthoIllinois
Rockford 4907959, Illinois 4896861, 61114
Status
Completed
Address
Dawes Fretzin Clinical Research Group, LLC
Indianapolis 4259418, Indiana 4921868, 46250
Status
Recruiting
Address
LSU Health Sciences Center Shreveport
New Orleans 4335045, Louisiana 4331987, 70112
Status
Recruiting
Address
Tufts Medical Center
Boston 4930956, Massachusetts 6254926, 02111
Status
Recruiting
Address
Brigham And Women's Hospital
Boston 4930956, Massachusetts 6254926, 02115
Status
Completed
Address
Essential Dermatology
Natick 4944994, Massachusetts 6254926, 01760
Status
Recruiting
Address
Beacon Clinical Research, LLC
Quincy 4948247, Massachusetts 6254926, 02169
Status
Completed
Address
University of Massachusetts, Worcester
Worcester 4956184, Massachusetts 6254926, 01655
Status
Recruiting
Address
David Fivenson, MD, Dermatology, PLLC
Ann Arbor 4984247, Michigan 5001836, 48103
Status
Recruiting
Address
Oakland Hills Dermatology
Auburn Hills 4984565, Michigan 5001836, 48326
Status
Completed
Address
AA MRC LLC Ahmed Arif Medical Research Center
Flint 4992982, Michigan 5001836, 48504
Status
Recruiting
Address
Revival Research Institute, LLC
Troy 5012639, Michigan 5001836, 48084
Status
Recruiting
Address
Saint Louis University
St Louis 4407066, Missouri 4398678, 63110
Status
Completed
Address
University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708, 68198
Status
Completed
Address
Albuquerque Center For Rheumatology
Albuquerque 5454711, New Mexico 5481136, 87102
Status
Completed
Address
University of New Mexico School of Medicine
Albuquerque 5454711, New Mexico 5481136, 87106
Status
Recruiting
Address
NYU Langone Brooklyn
Brooklyn 5110302, New York 5128638, 11220
Status
Recruiting
Address
Universal Dermatology, PLLC
Fairport 5116815, New York 5128638, 14450
Status
Recruiting
Address
Northwell Health, Inc. PRIME
Great Neck 5119218, New York 5128638, 11021
Status
Recruiting
Address
Columbia University Medical center
New York 5128581, New York 5128638, 10032
Status
Recruiting
Address
University of North Carolina at Chapel Hill
Chapel Hill 4460162, North Carolina 4482348, 27514
Status
Recruiting
Address
Duke Dermatology South Durham
Durham 4464368, North Carolina 4482348, 27710
Status
Completed
Address
Medication Management, LLC
Greensboro 4469146, North Carolina 4482348, 27405
Status
Recruiting
Address
University of Cincinnati Department of Dermatology
Cincinnati 4508722, Ohio 5165418, 45219
Status
Recruiting
Address
University Hospitals Cleveland Medical Center
Cleveland 5150529, Ohio 5165418, 44106
Status
Completed
Address
Ohio State University
Columbus 4509177, Ohio 5165418, 43210
Status
Completed
Address
Penn State University Milton S. Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927, 17033
Status
Recruiting
Address
University of Pennsylvania
Philadelphia 4560349, Pennsylvania 6254927, 19104
Status
Recruiting
Address
Vanderbilt University Medical Center
Nashville 4644585, Tennessee 4662168, 37232
Status
Recruiting
Address
Austin Regional Clinic, P.A.
Austin 4671654, Texas 4736286, 78731
Status
Recruiting
Address
Precision Comprehensive Clinical Research Solutions
Colleyville 4682478, Texas 4736286, 76034
Status
Completed
Address
Metroplex Clinical Research Center, LLC
Dallas 4684888, Texas 4736286, 75231
Status
Recruiting
Address
UT Southwestern Medical Center
Dallas 4684888, Texas 4736286, 75390-8896
Status
Recruiting
Address
North Texas Center for Clinical Research
Frisco 4692559, Texas 4736286, 75034
Status
Recruiting
Address
UTMB Department of Dermatology
Galveston 4692883, Texas 4736286, 77555-0583
Status
Recruiting
Address
University of Texas Health Science Center at Houston
Houston 4699066, Texas 4736286, 77054
Status
Recruiting
Address
Arthritis & Osteoporosis Clinic
Waco 4739526, Texas 4736286, 76710
Status
Recruiting
Address
University of Utah Health Sciences Center
Salt Lake City 5780993, Utah 5549030, 84132
Status
Completed
Address
West End Dermatology Associates
Richmond 4781708, Virginia 6254928, 23233
Status
Completed
Address
CINME - Centro De Investigaciones Metabolicas
CABA, Buenos Aires 3435907, C1056ABI
Status
Recruiting
Address
Centro de Investigaciones Medicas Mar del Plata
Mar del Plata 3430863, Buenos Aires 3435907, 7600
Status
Recruiting
Address
Instituto de Investigaciones Clinicas Quilmes
Quilmes 3429652, Buenos Aires 3435907, B1878GEG
Status
Recruiting
Address
APRILLUS Asistencia e Investigacion
Buenos Aires 3435910, Ciudad Autonoma Buenos Aires, C1406AGA
Status
Recruiting
Address
Fundacion Respirar
Buenos Aires 3435910, Ciudad Autonoma Buenos Aires, C1426ABO
Status
Recruiting
Address
Instituto CAICI
Rosario 3838583, Santa Fe Province 3836276, S2000PBJ
Status
Recruiting
Address
Clinica Mayo de Urgencias Medicas Cruz Blanca SRL
San Miguel de Tucumán 3836873, Tucumán Province 3833578, 4000
Status
Recruiting
Address
Centro de Investigaciones Medicas Tucuman
San Miguel de Tucumán 3836873, Tucumán Province 3833578, T4000AXL
Status
Recruiting
Address
Investigaciones Clinicas Tucuman
San Miguel de Tucumán 3836873, Tucumán Province 3833578, T4000ICL
Status
Recruiting
Address
Hospital Italiano de La Plata
Buenos Aires 3435910, , B1900AXI
Status
Recruiting
Address
Centro Privado de Medicina Familiar - Mind Out Research
Ciudad Autonoma Buenos Aires, , C1417
Status
Recruiting
Address
Clinica Adventista Belgrano
Ciudad Autonoma Buenos Aires, , C1430EGF
Status
Recruiting
Address
Instituto de Reumatologia
Mendoza 3844421, , M5500
Status
Recruiting
Address
CER San Juan Centro Polivalente de Asistencia e Inv. Clinica
San Juan 3837213, , 5400
Status
Recruiting
Address
HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará
Fortaleza 3399415, Ceará 3402362, 60430-370
Status
Recruiting
Address
CEDOES - Diagnóstico e Pesquisa
Vitória 3444924, Espírito Santo 3463930, 29055-450
Status
Recruiting
Address
Clínica SER da Bahia
Salvador 3450554, Estado de Bahia 3471168, 40150-150
Status
Recruiting
Address
L2IP - Instituto de Pesquisas Clínicas Ltda.
Brasília 3469058, Federal District 3463504, 70200-730
Status
Recruiting
Address
IPC MT Instituto de Pesquisas Clinicas do Mato Grosso
Santo Ângelo, Mato Grosso 3457419, 78020-500
Status
Recruiting
Address
Santa Casa de Misericordia de Belo Horizonte
Belo Horizonte 3470127, Minas Gerais 3457153, 30150-221
Status
Recruiting
Address
CMiP - Centro Mineiro de Pesquisa
Juiz de Fora 3459505, Minas Gerais 3457153, 36010-570
Status
Recruiting
Address
Instituto Brasil de Pesquisa Clínica-IBPCLIN S/A
Rio de Janeiro 3451190, Rio Do Janeiro, 20241-180
Status
Recruiting
Address
IDERJ - Instituto de Dermatologia e Estética do Brasil Ltda
Rio de Janeiro 3451190, Rio Do Janeiro, 22470-220
Status
Recruiting
Address
Hospital Bruno Born
Lajeado 3459035, Rio Grande do Sul 3451133, 95900-000
Status
Recruiting
Address
Hospital de Clínicas de Porto Alegre
Porto Alegre 3452925, Rio Grande do Sul 3451133, 90035-903
Status
Recruiting
Address
Nucleo de Pesquisa Clinica do Rio Grande do Sul
Porto Alegre 3452925, Rio Grande do Sul 3451133, 90430001
Status
Recruiting
Address
LMK Serviços Médicos S/S Ltda
Porto Alegre 3452925, Rio Grande do Sul 3451133, 90480-000
Status
Recruiting
Address
CEMEC - Centro Multidisciplinar de Estudos Clínicos
São Bernardo do Campo 3449344, São Paulo 3448433, 09715-090
Status
Recruiting
Address
CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos
São Paulo 3448439, São Paulo 3448433, 04266-010
Status
Recruiting
Address
Medical center Medconsult Pleven OOD
Pleven 728203, , 5800
Status
Recruiting
Address
UMHAT 'Dr. Georgi Stranski', EAD
Pleven 728203, , 5800
Status
Recruiting
Address
DCC 1 - Ruse, EOOD
Rousse 727523, , 7002
Status
Recruiting
Address
DCC 'Alexandrovska', EOOD
Sofia 727011, , 1431
Status
Recruiting
Address
DCC Focus 5 - MEOH OOD
Sofia 727011, , 1463
Status
Recruiting
Address
DCC Focus 5 - MEOH OOD
Sofia 727011, , 1463
Status
Recruiting
Address
Military Medical Academy - MHAT - Sofia
Sofia 727011, , 1606
Status
Recruiting
Address
Laser Rejuvenation Clinics, Inc.
Calgary 5913490, Alberta 5883102, T2W 4X9
Status
Recruiting
Address
Laster Rejuvenation Clinics Edmonton D.T. Inc.
Edmonton 5946768, Alberta 5883102, T5J 3S9
Status
Completed
Address
Medicor Research Inc
Greater Sudbury 5964700, Ontario 6093943, P3C 1X3
Status
Completed
Address
Dermatology Ottawa Research Centre
Ottawa 6094817, Ontario 6093943, K2C 3N2
Status
Recruiting
Address
DIEX Recherche Sherbrooke Inc.
Sherbrooke 6146143, Quebec 6115047, J1L 0H8
Status
Recruiting
Address
Centro Medico SkinMed
Las Condes 3884447, , 7580206
Status
Recruiting
Address
Dermacross
Santiago 3871336, , 66901
Status
Recruiting
Address
BioMedica Research Group
Santiago 3871336, , 7500710
Status
Recruiting
Address
CeCim Biocinetic
Santiago 3871336, , 8331143
Status
Recruiting
Address
CIEC - Centro Internacional de Estudios Clínicos
Santiago 3871336, , 8420383
Status
Recruiting
Address
Clinical Research Chile SpA.
Valdivia 3868707, , 5090000
Status
Recruiting
Address
Oncocentro APYS
Viña del Mar 3868121, , 2520598
Status
Recruiting
Address
Beijing Tongren Hospital, Capital Medical University
Beijing 1816670, Beijing Municipality 2038349, 100730
Status
Recruiting
Address
Peking Union Medical College Hospital
Beijing 1816670, Beijing Municipality 2038349, 100730
Status
Recruiting
Address
The First Affiliated Hospital of Chongqing Medical University
Chongqing 1814906, Chongqing Municipality 1814905, 400016
Status
Recruiting
Address
The First Affiliated Hospital of Fujian Medical University
Fuzhou 1810821, Fujian 1811017, 350005
Status
Recruiting
Address
Dongguan People's Hospital
Dongguan 1812545, Guangdong 1809935, 523059
Status
Recruiting
Address
Nanfang Hospital of Southern Medical University
Guangzhou 1809858, Guangdong 1809935, 510515
Status
Recruiting
Address
Shenzhen Second People's Hospital
Shenzhen 1795565, Guangdong 1809935, 518029
Status
Recruiting
Address
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Guangzhou 1809858, Guangzhou, 510120
Status
Recruiting
Address
Nanyang First People's Hospital
Nanyang 1799629, Henan 1808520, 473004
Status
Recruiting
Address
Henan Provincial People's Hospital
Zhengzhou 1784658, Henan 1808520, 450003
Status
Recruiting
Address
The second Xiangya Hospital of Central South University
Changsha 1815577, Hu'nan, 410011
Status
Recruiting
Address
The First Affiliated Hospital of Baotou Medical College
Baotou 2038432, Inner Mongolia 2035607, 014010
Status
Recruiting
Address
Hospital for Skin Diseases, Chinese Academy of Medical Sciences
Nanjing 1799962, Jiangsu 1806260, 210042
Status
Recruiting
Address
Affiliated Hospital of Jiangsu University
Zhenjiang 1784642, Jiangsu 1806260, 212001
Status
Recruiting
Address
The First Hospital of Jilin University
Changchun 2038180, Jilin 2036500, 130021
Status
Recruiting
Address
Qilu Hospital of Shandong University
Jinan 1805753, Shandong 1796328, 250012
Status
Recruiting
Address
Ruijin Hospital of Shanghai Jiaotong University School of Medicine
Shanghai 1796236, Shanghai Municipality 1796231, 200011
Status
Recruiting
Address
Zhongshan Hospital Fudan University
Shanghai 1796236, Shanghai Municipality 1796231, 200032
Status
Recruiting
Address
Shanghai Skin Disease Hospital
Shanghai 1796236, Shanghai Municipality 1796231, 200443
Status
Recruiting
Address
The Second Affiliated Hospital of Kunming Medical University
Kunming 1804651, Yunnan 1785694, 650101
Status
Recruiting
Address
The First Affiliated Hospital of Zhejiang University school of medicine
Hangzhou 1808926, Zhejiang 1784764, 310003
Status
Recruiting
Address
Hangzhou First People's Hospital
Hangzhou 1808926, Zhejiang 1784764, 310006
Status
Recruiting
Address
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou 1791388, Zhejiang 1784764, 325000
Status
Recruiting
Address
Centro de Investigacion Medico Asistencial S.A.S
Barranquilla 3689147, Atlántico 3689436, 80020
Status
Recruiting
Address
Healthy Medical Center
Zipaquirá 3665542, Cundinamarca 3685413, 250252
Status
Recruiting
Address
Servimed S.A.S.
Bucaramanga 3688465, Santander Department 3668578, 680003
Status
Recruiting
Address
Centro de Investigacion en Reumatologia y Especialidades Medicas SAS. CIREEM
Bogotá 3688689, , 110221
Status
Recruiting
Address
CHU Nice - Hopital de l Archet
Nice 2990440, Alpes Maritimes, 6200
Status
Recruiting
Address
Hôpital de la Timone
Marseille 2995469, Bouches-du-Rhône, 13385
Status
Recruiting
Address
CHU de Caen - Hopital de la Cote de Nacre
Caen 3029241, Calvados, 14033
Status
Recruiting
Address
CHU Besançon - Hôpital Jean Minjoz
Besançon 3033123, Doubs, 25030
Status
Recruiting
Address
Hopital Larrey
Toulouse 2972315, Haute Garonne, 31059
Status
Recruiting
Address
Hôpital Privé d'Antony
Antony 3037423, Hauts De Seine, 92160
Status
Recruiting
Address
Hopital Saint Eloi
Montpellier 2992166, Herault, 34295
Status
Recruiting
Address
Hôpital Saint-Louis
Cedex 10, Paris, 75475
Status
Recruiting
Address
Hopital Edouard Herriot - CHU Lyon
Lyon 2996944, Rhone, 69003
Status
Recruiting
Address
Hopital Tenon
Paris 2988507, , 75020
Status
Recruiting
Address
Universitaetsklinikum Heidelberg
Heidelberg 2907911, Baden-Wurttemberg 2953481, 69120
Status
Recruiting
Address
Universitaetsklinikum Erlangen
Erlangen 2929567, Bavaria 2951839, 91054
Status
Recruiting
Address
Fachklinik Bad Bentheim Dermatologie
Bad Bentheim 2953552, Lower Saxony 2862926, 48455
Status
Recruiting
Address
Elbekliniken Buxtehude GmbH
Buxtehude 2940451, Lower Saxony 2862926, 21614
Status
Recruiting
Address
Klinikum Oldenburg AoeR
Oldenburg 2857458, Lower Saxony 2862926, 26133
Status
Recruiting
Address
Universitaetsklinikum Aachen AoeR
Aachen 3247449, North Rhine-Westphalia 2861876, 52074
Status
Recruiting
Address
Universitaetsklinikum Bonn AoeR
Bonn 2946447, North Rhine-Westphalia 2861876, 53127
Status
Recruiting
Address
Universitaetsklinikum Duesseldorf AoeR
Düsseldorf 2934246, North Rhine-Westphalia 2861876, 40225
Status
Recruiting
Address
Universitaetsklinikum Muenster
Münster 2867543, North Rhine-Westphalia 2861876, 48149
Status
Recruiting
Address
Universitaetsklinikum Carl Gustav Carus TU Dresden
Dresden 2935022, Saxony 2842566, 1307
Status
Recruiting
Address
Universitaetsklinikum Halle (Saale)
Halle 2911522, Saxony-Anhalt 2842565, 6120
Status
Completed
Address
Universitaetsklinikum Schleswig-Holstein - Campus Kiel
Kiel 2891122, Schleswig-Holstein 2838632, 24105
Status
Recruiting
Address
Charité - Campus Charité Mitte
Berlin 2950159, , 10117
Status
Recruiting
Address
Pecsi Tudomanyegyetem
Pécs 3046526, , 7632
Status
Recruiting
Address
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
Bologna 3181928, , 40138
Status
Recruiting
Address
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
Brescia 3181554, , 25123
Status
Recruiting
Address
Università degli studi di Firenze
Florence 3176959, , 50121
Status
Recruiting
Address
IRCCS Ospedale Policlinico San Martino
Genova 8969657, , 16132
Status
Recruiting
Address
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
Milan 6951411, , 20122
Status
Recruiting
Address
Ospedale San Raffaele
Milan 6951411, , 20132
Status
Recruiting
Address
Azienda Ospedaliera Universitaria Policlinico 'Federico II'
Napoli 9031661, , 80131
Status
Recruiting
Address
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma 8957247, , 137
Status
Recruiting
Address
JCHO Chukyo Hospital
Nagoya 1856057, Aichi-ken 1865694, 457-8510
Status
Recruiting
Address
NHO Nagoya Medical Center
Nagoya 1856057, Aichi-ken 1865694, 460-0001
Status
Recruiting
Address
Fujita Health University Hospital
Toyoake-shi, Aichi-ken 1865694, 470-1192
Status
Recruiting
Address
Aomori Prefectural Central Hospital
Aomori 2130658, Aomori 2130656, 030-8553
Status
Recruiting
Address
Juntendo University Urayasu Hospital
Urayasu-shi, Chiba 2113014, 279-0021
Status
Recruiting
Address
University of Fukui Hospital
Yoshida-gun, Fukui 1863983, 910-1193
Status
Recruiting
Address
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, Fukuoka 1863958, 807-8556
Status
Recruiting
Address
Hokkaido University Hospital
Sapporo 2128295, Hokkaido 2130037, 060-8648
Status
Recruiting
Address
Kakogawa Central City Hospital
Kakogawa-shi, Hyōgo 1862047, 675-8611
Status
Recruiting
Address
Kita Harima Medical Center
Ono-shi, Hyōgo 1862047, 675-1392
Status
Recruiting
Address
Kanazawa University Hospital
Kanazawa 1860243, Ishikawa-ken 1861387, 920-8641
Status
Recruiting
Address
St. Marianna University Hospital
Kawasaki-shi, Kanagawa 1860291, 216-8511
Status
Recruiting
Address
Yokohama City University Medical Center
Yokohama 1848354, Kanagawa 1860291, 232-0024
Status
Recruiting
Address
Yokohama City University Hospital
Yokohama 1848354, Kanagawa 1860291, 236-0004
Status
Recruiting
Address
NHO Yokohama Medical Center
Yokohama 1848354, Kanagawa 1860291, 245-8575
Status
Recruiting
Address
Kumamoto University Hospital
Kumamoto 1858421, Kumamoto 1858419, 860-8556
Status
Recruiting
Address
Tohoku University Hospital
Sendai 2111149, Miyagi 2111888, 980-8574
Status
Recruiting
Address
Nagasaki University Hospital
Nagasaki 1856177, Nagasaki 1856156, 852-8501
Status
Recruiting
Address
Niigata University Medical & Dental Hospital
Niigata 1855431, Niigata 1855429, 951-8520
Status
Recruiting
Address
Japanese Red Cross Okayama Hospital
Okayama 1854383, Okayama-ken 1854381, 700-8607
Status
Recruiting
Address
NHO Osaka Minami Medical Center
Kawachinagano-shi, Osaka 1853904, 586-8521
Status
Recruiting
Address
Daini Osaka Police Hospital
Osaka 1853909, Osaka 1853904, 543-8922
Status
Recruiting
Address
Kindai University Hospital
Osakasayama-shi, Osaka 1853904, 589-8511
Status
Recruiting
Address
Osaka University Hospital
Suita-shi, Osaka 1853904, 565-0871
Status
Recruiting
Address
Takatsuki Red Cross Hospital
Takatsuki-shi, Osaka 1853904, 569-1096
Status
Recruiting
Address
Shiga University of Medical Science Hospital
Ōtsu 1853574, Shiga 1852553, 520-2192
Status
Recruiting
Address
Shimane University Hospital
Izumo-shi, Shimane 1852442, 693-8501
Status
Recruiting
Address
Teikyo University Hospital
Itabashi-ku, Tokyo-To, 173-8606
Status
Recruiting
Address
Showa University East Hospital
Shinagawa-ku, Tokyo-To, 142-0054
Status
Recruiting
Address
Wakayama Medical University Hospital
Wakayama 1926004, Wakayama 1848938, 641-8510
Status
Recruiting
Address
Centro de investigacion medica y reumatologia
Guadalajara 4005539, Jalisco 4004156, 44959
Status
Recruiting
Address
Centro de Investigacion Clínica GRAMEL S.C
Mexico City 3530597, Mexico City 3527646, 3720
Status
Recruiting
Address
Clinstile, S.A. de C.V.
Mexico City 3530597, Mexico City 3527646, 6700
Status
Recruiting
Address
Consultorio Privado Dr. Miguel Cortes Hernandez
Cuernavaca 3529947, Morelos 3522961, 62448
Status
Recruiting
Address
Medical Care & Research SA de CV
Mérida 3523349, Yucatán 3514211, 97070
Status
Recruiting
Address
Derma Norte del Bajio S.C.
Aguascalientes 4019233, , 20127
Status
Recruiting
Address
Investigacion y Biomedicina de Chihuahua, S.C.
Chihuahua City 4014338, , 31000
Status
Recruiting
Address
Invest Clinicas Sac Inst de Ginecologia y Reproduccion
Lima 3936456, , Lima 33
Status
Recruiting
Address
The Medical City Clark
Mabalacat 1704703, Pampanga, 2023
Status
Recruiting
Address
Cebu Doctors University Hospital
Cebu City 1717512, , 6000
Status
Recruiting
Address
Mary Mediatrix Medical Center
Lipa City 1706090, , 4217
Status
Recruiting
Address
Medical Center Manila
Manila 1701668, , 1000
Status
Recruiting
Address
Philippine General Hospital
Manila 1701668, , 1000
Status
Recruiting
Address
Jose R. Reyes Memorial Medical Center
Manila 1701668, , 1012
Status
Recruiting
Address
St. Luke's Medical Center
Quezon City 1692192, , 1102
Status
Recruiting
Address
Far Eastern University - Dr. Nicanor Reyes Medical Foundation
Quezon City, Metro Manila 1692192, , 1118
Status
Recruiting
Address
Ilocos Training and Regional Medical Center
San Fenando, La Union, , 2500
Status
Recruiting
Address
SPZOZ Szpital Uniwersytecki w Krakowie
Krakow 3094802, , 31-501
Status
Recruiting
Address
Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski
Krakow 3094802, , 31-530
Status
Recruiting
Address
Dermoklinika Centrum Medyczne SC M Kierstan J Narbutt A Lesiak
Lodz 3093133, , 90-436
Status
Recruiting
Address
Kliniczny Szpital Wojewodzki nr 1 im.F.Chopina
Rzeszów 759734, , 35-055
Status
Recruiting
Address
Szpital Kliniczny Dzieciatka Jezus
Warsaw 756135, , 02-008
Status
Recruiting
Address
Royalderm
Warsaw 756135, , 02-962
Status
Recruiting
Address
Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska
Wroclaw 3081368, , 50-566
Status
Recruiting
Address
Centro Hospitalar e Universitário de Coimbra, E.P.E (HUC)
Coimbra 2740637, , 3000-075
Status
Recruiting
Address
Hospital de Egas Moniz
Lisbon 2267057, , 1349-019
Status
Recruiting
Address
Hospital CUF Descobertas
Lisbon 2267057, , 1998-018
Status
Recruiting
Address
Centro Hospitalar Universitártio do Porto, E.P.E.
Porto 2735943, , 4099-001
Status
Completed
Address
Unidade Local de Saúde do Alto Minho, E.P.E.
Viana do Castelo 2732773, , 4904-858
Status
Completed
Address
Dr. Samuel Sanchez PSC
Caguas 4563008, , 00727
Status
Recruiting
Address
GCM Medical Group PSC - Hato Rey
San Juan 4568127, , 917
Status
Recruiting
Address
King Faisal Specialist Hospital & Research Center
Riyadh 108410, , 11211
Status
Recruiting
Address
King Saud University
Riyadh 108410, , 11461
Status
Recruiting
Address
Institute of Rheumatology
Belgrade 792680, , 11000
Status
Recruiting
Address
University Clinical Center of Serbia
Belgrade 792680, , 11000
Status
Recruiting
Address
University Clinical Center Kragujevac
Kragujevac 789128, , 34000
Status
Recruiting
Address
Clinical Center of Vojvodina
Novi Sad 3194360, , 21000
Status
Recruiting
Address
Artromac n.o.
Košice 724443, , 4011
Status
Recruiting
Address
Narodny ustav reumatickych chorob
Piešťany 3058202, , 92112
Status
Recruiting
Address
Korea University Ansan Hospital
Ansan-si 1846918, Gyeonggi-do 1841610, 15355
Status
Recruiting
Address
Ajou University Hospital
Suwon 1835553, Gyeonggi-do 1841610, 16499
Status
Recruiting
Address
Chonnam National University Hospital
Gwangju 1841811, , 61469
Status
Recruiting
Address
Severance Hospital, Yonsei University Health System
Seoul 1835848, , 3722
Status
Recruiting
Address
Hanyang University Seoul Hospital
Seoul 1835848, , 4763
Status
Recruiting
Address
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul 1835848, , 6591
Status
Recruiting
Address
Hospital Universitari Germans Trias i Pujol
Badalona 3129028, Barcelona, 8916
Status
Recruiting
Address
Hospital Universitario Rio Hortega
Valladolid, Cantabria 3336898, 47012
Status
Recruiting
Address
Hospital Universitario Fundacion Alcorcon
Alcorcón 3130564, Madrid 3117732, 28922
Status
Recruiting
Address
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda 3117667, Madrid 3117732, 28222
Status
Recruiting
Address
Complejo Hospitalario Universitario A Coruña
A Coruña 3119841, , 15006
Status
Recruiting
Address
Hospital del Mar
Barcelona 3128760, , 8003
Status
Recruiting
Address
Hospital de la Santa Creu i Sant Pau
Barcelona 3128760, , 8041
Status
Recruiting
Address
Hospital Universitario Reina Sofia
Córdoba 2519240, , 14004
Status
Recruiting
Address
Hospital Universitario Virgen del Rocio
Seville 2510911, , 41013
Status
Recruiting
Address
Karolinska Universitetssjukhuset - Solna
Stockholm 2673730, , 17176
Status
Recruiting
Address
Universitaetsspital Zuerich
Zurich-Flughafen, Canton of Zurich 2657895, 8058
Status
Recruiting
Address
Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne 2659994, , CH-1011
Status
Recruiting
Address
Kantonsspital St. Gallen
Sankt Gallen 2658822, , 9007
Status
Recruiting
Address
Changhua Christian Medical Foundation Changhua Christian Hospital
Changhua 1993459, , 50006
Status
Recruiting
Address
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City 1673820, , 833
Status
Recruiting
Address
Taichung Veterans General Hospital
Taichung 1668399, , 40705
Status
Recruiting
Address
Taipei Veterans General Hospital
Taipei 1668341, , 11217
Status
Recruiting
Address
Whipps Cross University Hospital
London 2643743, Greater London, E11 1NR
Status
Recruiting
Address
Manchester Royal Infirmary
Manchester 2643123, Greater Manchester, M13 9WL
Status
Recruiting
Address
Queen Elizabeth Hospital
Birmingham 2655603, West Midlands, B15 2GW
Status
Recruiting
Address
Chapel Allerton Hospital
Leeds 2644688, West Yorkshire, LS9 7TF