A Study to Assess the Efficacy and Safety of BIIB059 (Litifilimab) in Participants With Active Subacute Cutaneous Lupus Erythematosus (SCLE) and/or Chronic Cutaneous Lupus Erythematosus (CCLE) With or Without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy

Study Purpose

The primary objectives of the study are to evaluate the efficacy of BIIB059 (litifilimab) compared with placebo in reducing skin disease activity measured by the Cutaneous Lupus Activity of Physician's Global Assessment-Revised (CLA-IGA-R) score [Parts A and B (US)] and the Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity (CLASI-A) score [Part B (ROW)] in participants with active SCLE and/or CCLE with or without systemic manifestations and refractory and/or intolerant to antimalarials. The secondary objectives of the study are to evaluate the efficacy of BIIB059 in reducing SCLE and/or CCLE disease activity by CLA-IGA-R, CLASI-A; to evaluate additional efficacy parameters of BIIB059 in reducing SCLE and/or CCLE disease activity; safety; tolerability; and immunogenicity of BIIB059 [Parts A and B].

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Key

Inclusion Criteria:

1. Histologically confirmed (in the past or at Screening) diagnosis of CLE with or without systemic manifestations. 2. Must have active cutaneous manifestations that meet study criteria. 3. Must have a CLASI-A score ≥10. 4. Must have an active CLE lesion despite an adequate trial of antimalarial treatment. Key

Exclusion Criteria:

1. Any active skin conditions other than CLE that may interfere with the study assessments of CLE. 2. Active severe lupus nephritis. 3. Active neuropsychiatric SLE. 4. Use of immunosuppressive or disease-modifying treatments for SLE or CLE [via an oral, intravenous (IV), or SC route] that were initiated less than 12 weeks prior to randomization, have not been at a stable and allowable dose. NOTE: Other protocol defined Inclusion/Exclusion criteria may apply

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT05531565
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2/Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Biogen
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Medical Director
Principal Investigator Affiliation Biogen
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Puerto Rico, Spain, Sweden, Switzerland, Taiwan, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
Additional Details

BIIB059 is a humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting blood dendritic cell antigen 2 and is being investigated for the potential treatment of systemic lupus erythematosus and cutaneous lupus erythematosus.

Arms & Interventions

Arms

Experimental: Part A (Phase 2): BIIB059

Participants will receive BIIB059 subcutaneously (SC) once every 4 weeks (Q4W) from Week 0 to Week 20, with an additional dose of BIIB059 at Week 2 during the double-blind placebo-controlled (DBPC) treatment period. Following the DBPC treatment period, participants will receive BIIB059 during the extended treatment period (ETP) from Week 24 to Week 48, with an additional dose of BIIB059-matching placebo at Week 26.

Placebo Comparator: Part A (Phase 2): Placebo

Participants will receive BIIB059-matching placebo SC Q4W from Week 0 to Week 20, with an additional dose of BIIB59-matching placebo at Week 2 during the DBPC treatment period. Following the DBPC treatment period, participants will receive BIIB059 during the ETP from Week 24 to Week 48, with an additional dose of BIIB059 at Week 26.

Experimental: Part B (Phase 3): BIIB059

Participants will receive BIIB059 SC Q4W from Week 0 to Week 20, with an additional dose of BIIB059 at Week 2 during the DBPC treatment period. Following the DBPC treatment period, participants will receive BIIB059 during the ETP from Week 24 to Week 48, with an additional dose of BIIB059-matching placebo at Week 26.

Placebo Comparator: Part B (Phase 3): Placebo

Participants will receive BIIB059-matching placebo SC Q4W from Week 0 to Week 20, with an additional dose of BIIB59-matching placebo at Week 2 during the DBPC treatment period. Following the DBPC treatment period, participants will receive BIIB059 during the ETP from Week 24 to Week 48, with an additional dose of BIIB059 at Week 26.

Interventions

Drug: - BIIB059 (litifilimab)

Administered as specified in the treatment arm.

Drug: - Placebo

Administered as specified in the treatment arm.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Phoenix, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatology Research, PLLC

Phoenix, Arizona, 85032

Dermatology Research Associates, Los Angeles, California

Status

Recruiting

Address

Dermatology Research Associates

Los Angeles, California, 90045

Clinical Science Institute, Santa Monica, California

Status

Recruiting

Address

Clinical Science Institute

Santa Monica, California, 90404

Upland, California

Status

Recruiting

Address

Inland Rheumatology Clinical Trials, Inc.

Upland, California, 91786

Denver Arthritis Clinic, Denver, Colorado

Status

Recruiting

Address

Denver Arthritis Clinic

Denver, Colorado, 80230

Omega Research Debary, LLC, DeBary, Florida

Status

Recruiting

Address

Omega Research Debary, LLC

DeBary, Florida, 32713

Fort Lauderdale, Florida

Status

Recruiting

Address

Centre for Rheumatology, Immunology and Arthritis

Fort Lauderdale, Florida, 33309

Miami, Florida

Status

Recruiting

Address

University of Miami Miller School of Medicine

Miami, Florida, 33125

Medical Research Center of Miami, Miami, Florida

Status

Recruiting

Address

Medical Research Center of Miami

Miami, Florida, 33134

Dawes Fretzin Dermatology Group, LLC, Indianapolis, Indiana

Status

Recruiting

Address

Dawes Fretzin Dermatology Group, LLC

Indianapolis, Indiana, 46250

University of Massachusetts, Worcester, Worcester, Massachusetts

Status

Recruiting

Address

University of Massachusetts, Worcester

Worcester, Massachusetts, 01655

David Fivenson, MD, Dermatology, PLLC, Ann Arbor, Michigan

Status

Recruiting

Address

David Fivenson, MD, Dermatology, PLLC

Ann Arbor, Michigan, 48103

Grand Blanc, Michigan

Status

Recruiting

Address

AA MRC LLC Ahmed Arif Medical Research Center

Grand Blanc, Michigan, 48439

Revival Research Institute, LLC, Troy, Michigan

Status

Recruiting

Address

Revival Research Institute, LLC

Troy, Michigan, 48084

Saint Louis University, Saint Louis, Missouri

Status

Recruiting

Address

Saint Louis University

Saint Louis, Missouri, 63110

University of Nebraska Medical Center, Omaha, Nebraska

Status

Recruiting

Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Universal Dermatology, PLLC, Fairport, New York

Status

Recruiting

Address

Universal Dermatology, PLLC

Fairport, New York, 14450

Medication Management, LLC, Greensboro, North Carolina

Status

Recruiting

Address

Medication Management, LLC

Greensboro, North Carolina, 27405

Cleveland, Ohio

Status

Recruiting

Address

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106

University of Pennsylvania, Philadelphia, Pennsylvania

Status

Recruiting

Address

University of Pennsylvania

Philadelphia, Pennsylvania, 19104

Colleyville, Texas

Status

Recruiting

Address

Precision Comprehensive Clinical Research Solutions

Colleyville, Texas, 76034

Metroplex Clinical Research Center, LLC, Dallas, Texas

Status

Recruiting

Address

Metroplex Clinical Research Center, LLC

Dallas, Texas, 75231

UT Southwestern Medical Center at Dallas, Dallas, Texas

Status

Recruiting

Address

UT Southwestern Medical Center at Dallas

Dallas, Texas, 75390

Arthritis & Osteoporosis Clinic, Waco, Texas

Status

Recruiting

Address

Arthritis & Osteoporosis Clinic

Waco, Texas, 76710

Murray, Utah

Status

Recruiting

Address

University of Utah Health Sciences Center

Murray, Utah, 84107

West End Dermatology Associates, Richmond, Virginia

Status

Recruiting

Address

West End Dermatology Associates

Richmond, Virginia, 23233

International Sites

Investigaciones Clinicas Tucuman, San Miguel de Tucuman, Tucuman, Argentina

Status

Recruiting

Address

Investigaciones Clinicas Tucuman

San Miguel de Tucuman, Tucuman, T4000ICL

Dr. Samuel Sanchez PSC, Caguas, Puerto Rico

Status

Recruiting

Address

Dr. Samuel Sanchez PSC

Caguas, , 00727

Hospital Universitario Rio Hortega, Valladolid, Cantabria, Spain

Status

Recruiting

Address

Hospital Universitario Rio Hortega

Valladolid, Cantabria, 47012

Majadahonda, Madrid, Spain

Status

Recruiting

Address

Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid, 28222

Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Status

Recruiting

Address

Hospital de la Santa Creu i Sant Pau

Barcelona, , 8041

Hospital Universitario Reina Sofia, Cordoba, Spain

Status

Recruiting

Address

Hospital Universitario Reina Sofia

Cordoba, , 14004

Karolinska Universitetssjukhuset - Solna, Stockholm, Sweden

Status

Recruiting

Address

Karolinska Universitetssjukhuset - Solna

Stockholm, , 17176

Kantonsspital St. Gallen, St. Gallen, Switzerland

Status

Recruiting

Address

Kantonsspital St. Gallen

St. Gallen, , 9007

Taipei Veterans General Hospital, Taipei, Taiwan

Status

Recruiting

Address

Taipei Veterans General Hospital

Taipei, , 11217