A Study to Evaluate the Continuous Safety and Efficacy of Litifilimab (BIIB059) in Adults With Active Systemic Lupus Erythematosus
Study Purpose
The primary objective of this study is to evaluate the long-term safety and tolerability of litifilimab in participants with active systemic lupus erythematosus (SLE). The secondary objectives of this study are to evaluate the long-term effect of litifilimab on disease activity in participants with SLE, to evaluate the long-term effect of litifilimab in participants with SLE in maintaining low disease activity, to evaluate the effect of litifilimab in participants with active SLE in preventing irreversible organ damage, to assess long-term use of oral corticosteroid (OCS) with participants receiving litifilimab treatment, to assess the impact of litifilimab on participant-reported Health-Related Quality-of-Life Questionnaire (HRQoL), symptoms, and impacts of SLE, to evaluate long-term effect of litifilimab on laboratory parameters, and to evaluate immunogenicity of litifilimab.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Key
Inclusion Criteria:
- - Participants who completed 1 of the 52-week of the double-blind placebo-controlled, parent Phase 3 studies (230LE303 (NCT04895241) and 230LE304 (NCT04961567)) on study treatments with either litifilimab or placebo to Week 48 and attended the last study assessment visit at Week 52.
Exclusion Criteria:
- - Early parent Phase 3 studies treatment terminators (participants who discontinued study treatment before Week 52) - Early parent Phase 3 studies terminators (participants who withdrew from study participation and did not complete the 52 week treatment period) - Participants who developed moderate-to-severe worsening of organ-specific lupus manifestations that would require a change in antimalarials and/or immunosuppressive therapy (initiation of new treatment or increase in dose above the allowed maximum dose) - Use of other investigational drugs or off-label drugs used to treat SLE, cutaneous lupus, or lupus nephritis during the parent Phase 3 studies.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT05352919 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Biogen |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Medical Director |
| Principal Investigator Affiliation | Biogen |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry |
| Overall Status | Enrolling by invitation |
| Countries | Argentina, Australia, Belgium, Brazil, Bulgaria, Canada, Chile, China, Colombia, Czechia, France, Germany, Greece, Hungary, Israel, Italy, Japan, Korea, Republic of, Mexico, Netherlands, Peru, Philippines, Poland, Puerto Rico, Romania, Russian Federation, Serbia, Spain, Sweden, Taiwan, United Kingdom, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Systemic Lupus Erythematosus (SLE) |
This is an extension study for all participants who completed study 230LE303 (NCT04895241) and 230LE304 (NCT04961567) (parent phase 3 studies) through Week 52 and did not discontinue litifilimab or placebo. Eligible participants from parent phase 3 studies will be followed for up to 180 weeks.
Arms
Experimental: Litifilimab Low Dose
Participants who are receiving background nonbiologic lupus standard of care (SOC) therapy and received litifilimab low dose, subcutaneously (SC), every 4 weeks (Q4W) during the parent Phase 3 studies (i.e. studies 230LE303 [NCT04895241] or 230LE304 [NCT04961567]) will continue to receive litifilimab low dose, SC, Q4W from Day 1 up to 152 weeks with an additional dose of litifilimab-matching placebo at Week 2. Participants who are receiving background nonbiologic lupus SOC therapy and received litifilimab-matching placebo in the parent Phase 3 studies (i.e. studies 230LE303 [NCT04895241] or 230LE304 [NCT04961567]) will be randomized to receive litifilimab low dose, SC, Q4W from Day 1 up to 152 weeks with an additional dose at Week 2.
Experimental: Litifilimab High Dose
Participants who are receiving background nonbiologic lupus SOC therapy and received litifilimab high dose, SC, Q4W during the parent Phase 3 studies (i.e. studies 230LE303 [NCT04895241] or 230LE304 [NCT04961567]) will continue to receive litifilimab high dose, SC, Q4W from Day 1 up to 152 weeks with an additional dose of litifilimab-matching placebo at Week 2. Participants who are receiving background nonbiologic lupus SOC therapy and received litifilimab-matching placebo in the parent Phase 3 studies (i.e. studies 230LE303 [NCT04895241] or 230LE304 [NCT04961567]) will be randomized to receive litifilimab high dose, SC, Q4W from Day 1 up to 152 weeks with an additional dose at Week 2.
Interventions
Drug: - Litifilimab
Administered as specified in the treatment arm.
Drug: - Litifilimab-matching placebo
Administered as specified in the treatment arm.
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
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University of Alabama Hospital
Birmingham, Alabama, 35294
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Arizona Arthritis & Rheumatology Associates, P.C.
Phoenix, Arizona, 85032
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Wallace Rheumatic Study Center
Beverly Hills, California, 90211
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University of California San Diego School of Medicine
La Jolla, California, 92037-094
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Valerius Medical Group
Los Alamitos, California, 90720-5403
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University of Southern California
Los Angeles, California, 90033
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Providence Facey Medical Foundation
Mission Hills, California, 91345
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Inland Rheumatology Clinical Trials, Inc.
Upland, California, 91786
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Medvin Clinical Research
Whittier, California, 90606
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University of Colorado Denver
Aurora, Colorado, 80045
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Georgetown University Hospital-Medstar
Washington, District of Columbia, 20007
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Arthritis & Rheumatic Disease Specialties
Aventura, Florida, 33180
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RASF - Clinical Research Center
Boca Raton, Florida, 33486
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Clinical Research of West Florida - Corporate
Clearwater, Florida, 33765
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Omega Research Consultants
DeBary, Florida, 32713
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Centre for Rheumatology, Immunology and Arthritis
Fort Lauderdale, Florida, 33309
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University of Florida
Gainesville, Florida, 32610
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GNP Research at Mark Jaffe, MD
Hollywood, Florida, 33024
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Life Clinical Trials
Margate, Florida, 33063
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University of Miami Miller School of Medicine
Miami, Florida, 33136
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Rheumatology Associates of Central Florida
Orlando, Florida, 32806
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Believe Clinical Trials
Ruskin, Florida, 33573-6801
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Clinical Research of West Florida, Inc.
Tampa, Florida, 33606
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AdventHealth Medical Group
Tampa, Florida, 33613
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The Emory Clinic Emory University
Atlanta, Georgia, 30303
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Jefrey Lieberman, M.D., P.C.
Decatur, Georgia, 30033
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Arthritis Center of North Georgia
Gainesville, Georgia, 30501
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Rush University Medical Center
Chicago, Illinois, 60612
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Boston University School of Medicine
Boston, Massachusetts, 02118
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Address
University of Massachusetts
Worcester, Massachusetts, 01605
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Address
AA MRC LLC Ahmed Arif Medical Research Center
Grand Blanc, Michigan, 48439
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Address
Washington University, School of Medicine
Saint Louis, Missouri, 63110
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Saint Louis Rheumatology
Saint Louis, Missouri, 63117
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Address
Arthritis & Osteoporosis Associates, PA
Trenton, New Jersey, 08629-1986
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Address
Arthritis and Osteoporosis Associates of New Mexico
Las Cruces, New Mexico, 88011
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NYU Langone Ambulatory Care Brooklyn Heights
Brooklyn, New York, 11201
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University of Rochester Medical Center
Rochester, New York, 14642
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SUNY Upstate Medical Center
Syracuse, New York, 13210
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Joint and Muscle Research Institute
Charlotte, North Carolina, 28204
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DJL Clinical Research, PLLC
Charlotte, North Carolina, 28210
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Medication Management, LLC
Greensboro, North Carolina, 27405
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Carolina Arthritis Associates
Wilmington, North Carolina, 28401
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University of Cincinnati
Cincinnati, Ohio, 45242
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Paramount Medical Research & Consulting, LLC
Middleburg Heights, Ohio, 44130
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Address
STAT Research
Springboro, Ohio, 45066
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Address
Wake Forest University Health Sciences
Sayre, Pennsylvania, 18840
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Piedmont Arthritis Clinic, P.A.
Greenville, South Carolina, 29601
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Low Country Rheumatology, PA
Summerville, South Carolina, 29486
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West Tennessee Research Institute
Jackson, Tennessee, 38305
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Ramesh C Gupta, MD
Memphis, Tennessee, 38119
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232-0028
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Office of John P. Lavery M.D., PA
Allen, Texas, 75013
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Tekton Research
Austin, Texas, 78745
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Precision Comprehensive Clinical Research Solution
Colleyville, Texas, 77034
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Precision Comprehensive Clinical Research Solutions
Fort Worth, Texas, 76107
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Accurate Clinical Research, Inc.
Houston, Texas, 77089
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Accurate Clinical Research
Houston, Texas, 77089
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Pioneer Research Solutions, Inc.
Houston, Texas, 77095
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SouthWest Rheumatology Research, LLC
Mesquite, Texas, 75150
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Sun Research Institute, LLC
San Antonio, Texas, 78215
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The University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
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Advanced Rheumatology of Houston
The Woodlands, Texas, 77382
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Address
CLS Research Ctr, PLLC
Webster, Texas, 77598
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Swedish Medical Center
Seattle, Washington, 98122
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University of Washington Medical Centre
Seattle, Washington, 98195
International Sites
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Nagasaki University Hospital
Nagasaki-shi, Nagasaki-Ken, 852-8501
Status
Address
NHO Osaka Minami Medical Center
Kawachi-Nagano, Osaka-Fu, 586-8521
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Address
Kitano Hospital
Osaka-shi, Osaka-Fu, 530-8480
Status
Address
Kindai University Hospital
Osakasayama-shi, Osaka-Fu, 589-8511
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Address
Osaka Medical and Pharmaceutical University Hospital
Takatsuki-shi, Osaka-Fu, 569-8686
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Address
Saitama Medical University Hospital
Iruma-gun, Saitama-Ken, 350-0495
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Address
Tokyo Medical and Dental University Hospital
Bunkyo-ku, Tokyo-To, 113-8519
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Address
St. Luke's International Hospital
Chuo-ku, Tokyo-To, 104-8560
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Address
Nihon University Itabashi Hospital
Itabashi-ku, Tokyo-To, 173-8610
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Address
Toho University Ohashi Medical Center
Meguro-ku, Tokyo-To, 153-8515
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Toho University Omori Medical Center
Ota-ku, Tokyo-To, 143-8541
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Keio University Hospital
Shinjuku-ku, Tokyo-To, 160-8582
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Center Hospital of the National Center for Global Health and Medicine
Shinjuku-ku, Tokyo-To, 162-8655
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Ajou University Hospital
Suwon, Gyeonggi-do, 16499
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Dong-A University Hospital
Busan, , 49201
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Gachon University Gil Medical Center
Incheon, , 21565
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Hanyang University Seoul Hospital
Seoul, , 04763
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Konkuk University Medical Center
Seoul, , 05030
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Asan Medical Center
Seoul, , 05505
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Clinstile, S.A. de C.V.
Ciudad de México, Distrito Federal, 06700
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Centro de Investigacion Clínica GRAMEL S.C
Mexico, Distrito Federal, 03720
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Address
Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran
Mexico, Distrito Federal, 14080
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Address
Diseño y Planeacion en Investigacion Medica S.C.
Guadalajara, Jalisco, 44130
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Clinica de Investigacion en Reumatologia y Obesidad S.C.
Guadalajara, Jalisco, 44650
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Consultorio Particular del Dr. Miguel Cortes Hernandez
Cuernavaca, Morelos, 62290
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Address
Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez
Monterrey, Nuevo León, 64460
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Address
Centro Peninsular de Investigacion Clinica, SCP
Merida, Yucatán, 97000
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Medical Care & Research SA de CV
Yucatan, Yucatán, 97070
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Investigacion y Biomedicina de Chihuahua, S.C.
Chihuahua, , 31000
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Centro de Investigacion y Atencion Integral Durango CIAID
Durango, , 34080
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Amsterdam UMC, Locatie VUMC
Amsterdam, , 1081 HV
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Universitair Medisch Centrum Groningen
Groningen, , 9700 RB
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Maastricht University Medical Center
Maastricht, , 6229 HX
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UMC Utrecht
Utrecht, , 3508 GA
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Hogar Clínica San Juan de Dios - Arequipa
Arequipa, , 04001
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Hospital Nacional Edgardo Rebagliati Martins
Lima, , LIMA 11
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HMA - Hospital Maria Auxiliadora
Lima, , LIMA 29
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Clinica San Felipe - Centro de Investigacion Clinica Inmunoreumatologia
Lima, , Lima 31
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Davao Doctors Hospital
Davao City, , 8000
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Mary Mediatrix Medical Center
Lipa City, , 4217
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Medical Center Manila
Manila, , 1000
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Philippine General Hospital
Manila, , 1000
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The Medical City Clark
Manila, , 1000
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Manila Doctors Hospital
Manila, , 1004
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University of Santo Tomas
Manila, , 1015
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St. Luke's Medical Center
Quezon City, , 1102
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Far Eastern University - Dr. Nicanor Reyes Medical Foundation
Quezon City, , 1118
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Nova Reuma Domysławska i Rusiłowicz, Spółka Partnerska Lekarza Reumatologa i Fizjoterapeuty
Bialystok, , 15-707
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Szpital Uniwersytecki nr 2 im.dr J. Biziela
Bydgoszcz, , 85-168
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Centrum Medyczne Intercor Sp. z o.o
Bydgoszcz, , 85-312
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Nzoz Bif-Med
Bytom, , 41-902
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Centrum Badawcze Panaceum Agnieszka Brzezicka, Magdalena Lenkiewicz Sp. z o.o.
Elblag, , 82-300
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Centrum Medyczne All-Med
Krakow, , 30-033
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Pratia MCM Krakow
Krakow, , 30-510
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Centrum Medyczne Plejady
Kraków, , 30-363
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Reumed Spolka z o.o.
Lublin, , 20-582
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SP Szpital Kliniczny nr 1 PUM im. prof. Tadeusza Sokolowskiego
Szczecin, , 71-252
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Address
MICS Centrum Medyczne Warszawa
Warszawa, , 00-660
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Address
Niepubliczny Zakład Opieki Zdrowotnej "Biogenes" Sp. z o.o.
Wroclaw, , 50-556
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Address
Centro Reumatologico
Caguas, , 00725
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Address
S.C Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L
Brasov, , 500283
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S C Delta Health Care SRL
Bucuresti, , 014461
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Spitalul Clinic Judetean de Urgenta Cluj Napoca
Cluj-Napoca, , 400006
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S.C.Centrul Medical Unirea SRL
Iasi, , 700661
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S.C Centrul Medical Unirea SRL
Targu Mures, , 540136
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LLC "Medical Center" Revma-Med "
Kemerovo, , 650070
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Olla-Med, Llc
Moscow, , 105554
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V.A. Nasonova Research Rheumatology Institute
Moscow, , 115522
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SBIH "Orenburg Regional Clinical Hospital"
Orenburg, , 460000
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SPb SBIH "Clinical Rheumatological Hospital # 25"
Saint Petersburg, , 190068
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Clinical Hospital Center "Bezanijska kosa"
Belgrade, , 11000
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Institute of Rheumatology
Belgrade, , 11000
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University Clinical Center of Serbia
Belgrade, , 11000
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Institute of Treatment and Rehabilitation "Niska Banja"
Niska Banja, , 18205
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Hospital Universitario Marques de Valdecilla
Santander, Cantabria, 39008
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Hospital Universitari Vall d'Hebron
Barcelona, , 08035
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Hospital Universitario San Cecilio
Granada, , 18016
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Hospital Universitario Virgen Macarena
Sevilla, , 41009
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Hospital Quironsalud Infanta Luisa
Sevilla, , 41089
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Hospital Universitario Dr. Peset
Valencia, , 46017
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Skåne University Hospital
Lund, , 22185
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Karolinska Universitetssjukhuset Solna
Stockholm, , 17176
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Akademiska Sjukhuset
Uppsala, , 75185
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Universitetssjukhuset Orebro
Örebro, , 70185
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Kaohsiung Chang Gung Memorial Hospital
Kaohsiung, , 83301
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Chang Gung Memorial Hospital,Linkou
Taoyuan, , 333
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Address
Whipps Cross University Hospital
Leytonstone, Greater London, E11 1NR
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St Thomas' Hospital
London, Greater London, SE1 9RT
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Doncaster Royal Infirmary
Doncaster, South Yorkshire, DN2 5LT
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Cannock Chase Hospital
Cannock, Staffordshire, WS11 5XY
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Hospital Italiano de La Plata
La Plata, Buenos Aires, B1900AXI
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Centro de Investigaciones Medicas Mar del Plata
Mar del Plata, Buenos Aires, B7600FYK
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Investigaciones Clinicas Tucuman
San Miguel de Tucuman, Tucuman, T4000ICL
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Instituto de Investigaciones Clinicas Quilmes
Buenos Aires, , B1878GEG
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Hospital General de Agudos Dr. J. M. Ramos Mejia
Buenos Aires, , C1430
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Centro Dermatologico Schejtman
Ciudad Autonoma Buenos Aires, , 1425
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STAT Research S.A.
Ciudad Autonoma Buenos Aires, , C1013AAB
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Centro Privado de Medicina Familiar - Mind Out Research
Ciudad Autonoma Buenos Aires, , C1417
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Instituto de Reumatologia
Mendoza, , M5500
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CER San Juan Centro Polivalente de Asistencia e Inv. Clinica
San Juan, , 5400
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Centro de Investigaciones Medicas Tucuman
Tucuman, , T4000AXL
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Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050
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Box Hill Hospital
Caulfield, Victoria, 3162
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Footscray Hospital
Footscray, Victoria, 3011
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Fiona Stanley Hospital
Murdoch, Western Australia, 6150
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UZ Leuven
Leuven, , 3000
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CHU de Liège
Liege, , 4000
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Address
Clínica SER da Bahia
Salvador, Bahia, 40150-150
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Address
HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará
Fortaleza, Ceará, 60430-275
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Address
L2IP - Instituto de Pesquisas Clínicas Ltda.
Brasilia, Distrito Federal, 70200-740
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Address
CEDOES - Diagnóstico e Pesquisa
Vitória, Espírito Santo, 29055-450
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Address
Oncovida - Centro de Onco-Hematologia de Mato Grosso
Cuiabá, Mato Grosso, 78040-360
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Address
Santa Casa de Misericórdia de Belo Horizonte
Belo Horizonte, Minas Gerais, 30150-221
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Address
CMiP - Centro Mineiro de Pesquisa
Juiz de Fora, Minas Gerais, 36010-570
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Address
CETI - Centro de Estudos em Terapias Inovadoras Ltda.
Curitiba, Paraná, 80030-110
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Address
LMK Serviços Médicos S/S Ltda
Porto Alegre, Rio Grande Do Sul, 90480-000
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Address
Hospital das Clínicas da Faculdade de Medicina da UNICAMP
Campinas, Sao Paulo, 13083-881
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Address
Centro Multidisciplinar de Estudos Clínicos - CEMEC
Santo André, Sao Paulo, 09190-510
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Address
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, Sao Paulo, 15090-000
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CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos
São Paulo, Sao Paulo, 01228-200
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MC Artmed OOD
Plovdiv, , 4002
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Address
UMHAT "Pulmed" OOD
Plovdiv, , 4002
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UMHAT-Plovdiv AD
Plovdiv, , 4003
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DCC 1 - Ruse, EOOD
Ruse, , 7002
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DCC "Alexandrovska", EOOD
Sofia, , 1431
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UMHAT "Sv. Ivan Rilski", EAD
Sofia, , 1431
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Medical Center Hera EOOD
Sofia, , 1510
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Military Medical Academy - MHAT - Sofia
Sofia, , 1606
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UMHAT "Sv. Ivan Rilski", EAD
Sofia, , 1612
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The Waterside Clinic
Barrie, Ontario, L4M 6L2
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Address
Hamilton Health Sciences Corporation
Hamilton, Ontario, L8N 1Y2
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University of Toronto
Toronto, Ontario, M5T 2S8
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Clinica Alemana de Osorno
Osorno, , 1530 531
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Centro Medico Prosalud
Santiago, , 7500000
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Interin
Santiago, , 7500010
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Address
CTR Estudios
Santiago, , 7500571
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Address
Enroll Spa
Santiago, , 7500588
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Address
BioMedica Research Group
Santiago, , 7500710
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Address
SOMEAL
Santiago, , 7510186
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Address
Beijing Chaoyang Hospital, Capital Medical University
Beijing, Beijing, 100020
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Address
Peking Union Medical College Hospital
Beijing, Beijing, 100032
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Address
The Third Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510630
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Address
Shenzhen People's Hospital
Shenzhen, Guangdong, 518020
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Address
Hainan General Hospital
Haikou, Hainan, 570311
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Address
Union Hospital, Tongji Medical College of Huazhong University of Science & Technology
Wuhan, Hubei, 430022
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Address
Xiangya Hospital, Central South University
Changsha, Hunan, 410008
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The 2nd Xiangya Hospital of Central South University
Changsha, Hunan, 410011
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ZhuZhou Central Hospital
ZhuZhou, Hunan, 412000
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Jiujiang No.1 People's Hospital
Jiujiang, Jiangxi, 332000
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The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006
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Jiangxi Pingxiang People's Hospital
Pingxiang, Jiangxi, 337055
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The First Hospital of Jilin University
Changchun, Jilin, 130021
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Binzhou Medical University Hospital
Binzhou, Shandong, 256603
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Address
Renji Hospital Shanghai Jiaotong University School of Medicine - West Branch
Shanghai, Shanghai, 200001
Status
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Ruijin Hospital of Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai, 200025
Status
Address
The First Affiliated Hospital of Chengdu Medical College
Chengdu, Sichuan, 610500
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Address
Tianjin Medical University General Hospital
Tianjin, Tianjin, 300052
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Address
People's Hospital of Xinjiang Uighur Autonomous Region
Urumqi, Xinjiang, 830001
Status
Address
Ningbo First Hospital
Ningbo, Zhejiang, 315010
Status
Address
Wenzhou People's Hospital
Wenzhou, Zhejiang, 325000
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Address
Centro de Investigacion Medico Asistencial S.A.S
Barranquilla, , 080020
Status
Address
Clínica de la Costa Ltda.
Barranquilla, , 080020
Status
Address
Centro de Investigacion en Reumatologia y Especialidades Medicas CIREEM S.A.S.
Bogotá, , 110221
Status
Address
Servimed S.A.S.
Bucaramanga, , 680003
Status
Address
Preventive Care Ltda
Chia, , 250001
Status
Address
Healthy Medical Center
Zipaquirá, , 250252
Status
Address
Fakultni nemocnice Brno
Brno, , 625 00
Status
Address
Revmatologie s.r.o.
Brno, , 638 00
Status
Address
Fakultni nemocnice Olomouc
Olomouc, , 77520
Status
Address
Groupe Hospitalier Pellegrin - Hôpital Pellegrin
Bordeaux, Gironde, 33706
Status
Address
Hopital Lapeyronie
Montpellier Cedex 5, Herault, 34295
Status
Address
CHU Clermont Ferrand - Hopital Gabriel Montpied
Clermont-Ferrand cedex 1, Puy De Dome, 63003
Status
Address
Hôpital Cochin
Paris, , 75014
Status
Address
Universitaetsmedizin Goettingen
Göttingen, Niedersachsen, 37075
Status
Address
Medizinische Hochschule Hannover
Hannover, Niedersachsen, 30625
Status
Address
Universitaetsklinikum Koeln
Koeln, Nordrhein Westfalen, 50937
Status
Address
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
Mainz, Rheinland Pfalz, 55131
Status
Address
General Hospital of Athens Laiko
Athens, , 11527
Status
Address
University General Hospital "Attikon"
Athens, , 12462
Status
Address
Obudai Egeszsegugyi Centrum Kft.
Budapest, , 1036
Status
Address
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
Budapest, , 1097
Status
Address
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza
Gyula, , 5700
Status
Address
Vita Verum Medical Egeszsegugyi Szolgaltato
Szekesfehervar, , 8000
Status
Address
Vital Medical Center
Veszprem, , 8200
Status
Address
Rambam Health Care Center
Haifa, , 3109601
Status
Address
Meir Medical Center
Kfar- Sava, , 4428164
Status
Address
Rabin Medical Center-Beilinson Campus
Petach-Tikva, , 4941492
Status
Address
Chaim Sheba Medical Center
Ramat Gan, , 5265602
Status
Address
Tel Aviv Sourasky Medical Center Pt
Tel Aviv, , 6423906
Status
Address
Istituto Clinico Humanitas
Rozzano, Milano, 20089
Status
Address
Ospedale M. Scarlato
Scafati, Salerno, 84018
Status
Address
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
Brescia, , 25123
Status
Address
Azienda Socio Sanitaria Territoriale Gaetano Pini (Gaetano Pini-CTO)
Milano, , 20122
Status
Address
Azienda Ospedaliera di Padova
Padova, , 35100
Status
Address
Azienda Ospedaliero Universitaria Pisana
Pisa, , 56100
Status
Address
Azienda Ospedaliera San Camillo Forlanini
Roma, , 00151
Status
Address
Università Campus Bio-Medico di Roma
Roma, , 00155
Status
Address
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza
Roma, , 00161
Status
Address
JCHO Chukyo Hospital
Nagoya-shi, Aichi-Ken, 457-8510
Status
Address
Fujita Health University Hospital
Toyoake-shi, Aichi-Ken, 470-1192
Status
Address
NHO Chibahigashi National Hospital
Chiba-shi, Chiba-Ken, 260-8712
Status
Address
Chibaken Saiseikai Narashino Hospital
Narashino-shi, Chiba-Ken, 275-8580
Status
Address
KKR Hamanomachi Hospital
Fukuoka-shi, Fukuoka-Ken, 810-8539
Status
Address
NHO Kyushu Medical Center
Fukuoka-shi, Fukuoka-Ken, 810-8563
Status
Address
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, Fukuoka-Ken, 807-8556
Status
Address
Hiroshima University Hospital
Hiroshima-shi, Hiroshima-Ken, 734-8551
Status
Address
Tonan Hospital
Sapporo-shi, Hokkaido, 060-0004
Status
Address
Japanese Red Cross Society Himeji Hospital
Himeji-shi, Hyogo-Ken, 670-8540
Status
Address
Kobe University Hospital
Kobe-shi, Hyogo-Ken, 650-0017
Status
Address
Kobe City Hospital Organization Kobe City Medical Center General Hospital
Kobe-shi, Hyogo-ken, 650-0047
Status
Address
Kagawa University Hospital
Kita-gun, Kagawa-Ken, 761-0793
Status
Address
St. Marianna University Hospital
Kawasaki-shi, Kanagawa-Ken, 216-8511
Status
Address
Kitasato University Hospital
Sagamihara-shi, Kanagawa-Ken, 252-0375
Status
Address
Yokohama City University Medical Center
Yokohama-shi, Kanagawa-Ken, 232-0024
Status
Address
NHO Yokohama Medical Center
Yokohama-shi, Kanagawa-Ken, 245-8575
Status
Address
Japanese Red Cross Kumamoto Hospital
Kumamoto-shi, Kumamoto-Ken, 861-8520
Status
Address
Tohoku University Hospital
Sendai-shi, Miyagi-Ken, 980-8574
