A Study to Evaluate the Efficacy and Safety of Litifilimab (BIIB059) in Adult Participants With Active Systemic Lupus Erythematosus Receiving Background Nonbiologic Lupus Standard of Care

Study Purpose

The primary objective of this study is to demonstrate efficacy of litifilimab (BIIB059) compared with placebo in participants with active systemic lupus erythematosus (SLE), who are receiving background lupus standard of care (SOC) therapy in reducing disease activity. The secondary objectives of this study are to demonstrate early onset of efficacy of litifilimab compared with placebo in participants with active SLE, who are receiving background lupus SOC therapy in reducing disease activity; to demonstrate organ-specific efficacy of litifilimab compared with placebo in participants with active SLE, who are receiving background lupus SOC therapy in reducing joint disease activity; to demonstrate effect of litifilimab compared with placebo in reducing oral corticosteroid(s) (OCS) use; to demonstrate organ-specific efficacy of litifilimab compared with placebo in participants with active SLE, who are receiving background lupus SOC therapy in reducing skin disease activity; to demonstrate efficacy of litifilimab compared with placebo in participants with active SLE, who are receiving background lupus SOC therapy in reducing occurrence of flare up to Week 52; to evaluate additional efficacy of litifilimab compared with placebo in reducing disease activity with additional disease activity measures; to evaluate the effect of litifilimab compared with placebo in reducing OCS use; to assess the difference between litifilimab and placebo on participant-reported health-related quality of life (HRQoL), symptoms, and impacts of SLE; to evaluate the safety and tolerability of litifilimab in participants with active SLE and to evaluate immunogenicity of litifilimab in participants with active SLE.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Key

Inclusion Criteria:

  • - Participant must be diagnosed with SLE at least 24 weeks prior to screening and must meet the 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for SLE, at screening by a qualified physician.
  • - Participant has a modified Systemic Lupus Erythematosus Disease Activity Index-200 (SLEDAI-2K) score ≥6 (excluding alopecia, fever, lupus-related headache, and organic brain syndrome) at screening (adjudicated).
  • - Participant has a modified clinical SLEDAI-2K score ≥4 (excluding anti-dsDNA, low complement component 3 [C3] and/or complement component 4 [C4], alopecia, fever, lupus-related headache, and organic brain syndrome) at screening (adjudicated) and randomization.
  • - Participant has BILAG-2004 grade A in ≥1 organ system or BILAG-2004 grade B in ≥2 organ systems at screening (adjudicated) and randomization.
  • - Participants must be treated with one of the following background nonbiologic lupus SOC therapies, initiated ≥12 weeks prior to screening and at stable dose ≥4 weeks prior to randomization: 1.
Antimalarials as stand-alone treatment. 2. Antimalarial treatment in combination with OCS and/or a single immunosuppressant. 3. Treatment with OCS and/or a single immunosuppressant. Key

Exclusion Criteria:

  • - History of or positive test result for human immunodeficiency virus (HIV).
  • - Current hepatitis C infection (defined as positive hepatitis C virus [HCV] antibody and detectable HCV ribonucleic acid [RNA]).
  • - Current hepatitis B infection (defined as positive for antibody to hepatitis B surface antigen [HBsAg] and/or positive for total antibody to hepatitis B core antigen [anti-HBc] with positive reflex HBV DNA).
  • - History of severe herpes infection.
  • - Presence of uncontrolled or New York Heart Association class III or IV congestive heart failure.
  • - Active severe lupus nephritis where, in the opinion of the investigator, protocol-specified SOC is insufficient and use of a more aggressive therapeutic approach, such as adding intravenous (IV) cyclophosphamide and/or high-dose IV pulse corticosteroid therapy or other treatments not permitted in the protocol, is indicated; or urine protein-creatinine ratio >2.0 or severe chronic kidney disease (estimated glomerular filtration rate <30 milliliters per minute per 1.73 meter square [mL/min/1.73 m^2]) calculated using the abbreviated Modification of Diet in Renal Disease equation.
  • - Any active skin conditions other than cutaneous lupus erythematosus (CLE) that may interfere with the study assessment of CLE such as but not limited to psoriasis, dermatomyositis, systemic sclerosis, non-LE skin lupus manifestation or drug-induced lupus.
  • - History or current diagnosis of a clinically significant non-SLE-related vasculitis syndrome.
  • - Active neuropsychiatric SLE.
  • - Use of oral prednisone (or equivalent) above 20 mg/day.
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04961567
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Biogen
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Medical Director
Principal Investigator Affiliation Biogen
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Belgium, Canada, China, Colombia, Czechia, Germany, Hungary, Israel, Italy, Japan, Netherlands, Puerto Rico, Romania, Serbia, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Lupus Erythematosus, Systemic
Study Website: View Trial Website
Arms & Interventions

Arms

Experimental: Litifilimab High Dose

Participants who are receiving background nonbiologic lupus SOC therapy will receive high dose of litifilimab, subcutaneously (SC), every 4 weeks (Q4W), up to Week 48 with an additional dose at Week 2.

Experimental: Litifilimab Low Dose

Participants who are receiving background nonbiologic lupus SOC therapy will receive low dose of litifilimab, SC Q4W, up to Week 48 with an additional dose at Week 2.

Placebo Comparator: Placebo

Participants who are receiving background nonbiologic lupus SOC therapy will receive litifilimab-matching placebo, SC Q4W, up to Week 48 with an additional dose at Week 2.

Interventions

Drug: - Litifilimab

Administered as specified in the treatment arm.

Drug: - Placebo

Administered as specified in the treatment arm.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

University of Alabama Birmingham, Birmingham, Alabama

Status

Recruiting

Address

University of Alabama Birmingham

Birmingham, Alabama, 35294

Glendale, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatology Associates, P.C.

Glendale, Arizona, 85306

Valerius Medical Group, Los Alamitos, California

Status

Recruiting

Address

Valerius Medical Group

Los Alamitos, California, 90720

Medvin Clinical Research, Whittier, California

Status

Recruiting

Address

Medvin Clinical Research

Whittier, California, 90602

RASF - Clinical Research Center, Boca Raton, Florida

Status

Completed

Address

RASF - Clinical Research Center

Boca Raton, Florida, 33486

University of Florida Gainesville, Gainesville, Florida

Status

Recruiting

Address

University of Florida Gainesville

Gainesville, Florida, 32611

Miami, Florida

Status

Recruiting

Address

University of Miami Miller School of Medicine

Miami, Florida, 33136

Clinical Research of West Florida, Inc., Tampa, Florida

Status

Recruiting

Address

Clinical Research of West Florida, Inc.

Tampa, Florida, 33606

The Emory Clinic Emory University, Atlanta, Georgia

Status

Recruiting

Address

The Emory Clinic Emory University

Atlanta, Georgia, 30322

Jefrey Lieberman, M.D., P.C., Decatur, Georgia

Status

Completed

Address

Jefrey Lieberman, M.D., P.C.

Decatur, Georgia, 30033

Arthritis Center of North Georgia, Gainesville, Georgia

Status

Recruiting

Address

Arthritis Center of North Georgia

Gainesville, Georgia, 30501

Rush University Medical Center, Chicago, Illinois

Status

Recruiting

Address

Rush University Medical Center

Chicago, Illinois, 60612

Boston University School of Medicine, Boston, Massachusetts

Status

Recruiting

Address

Boston University School of Medicine

Boston, Massachusetts, 02118

University of Massachusetts, Worcester, Massachusetts

Status

Recruiting

Address

University of Massachusetts

Worcester, Massachusetts, 01605

Saint Louis Rheumatology, Saint Louis, Missouri

Status

Recruiting

Address

Saint Louis Rheumatology

Saint Louis, Missouri, 63117

Arthritis & Osteoporosis Associates, PA, Freehold, New Jersey

Status

Completed

Address

Arthritis & Osteoporosis Associates, PA

Freehold, New Jersey, 07728

Las Cruces, New Mexico

Status

Recruiting

Address

Arthritis and Osteoporosis Associates of New Mexico

Las Cruces, New Mexico, 88011

DJL Clinical Research, PLLC, Charlotte, North Carolina

Status

Recruiting

Address

DJL Clinical Research, PLLC

Charlotte, North Carolina, 28210

Carolina Arthritis Associates, Wilmington, North Carolina

Status

Recruiting

Address

Carolina Arthritis Associates

Wilmington, North Carolina, 28401

University of Cincinnati, Cincinnati, Ohio

Status

Recruiting

Address

University of Cincinnati

Cincinnati, Ohio, 45219

STAT Research, Dayton, Ohio

Status

Recruiting

Address

STAT Research

Dayton, Ohio, 45417

Piedmont Arthritis Clinic, P.A., Greenville, South Carolina

Status

Recruiting

Address

Piedmont Arthritis Clinic, P.A.

Greenville, South Carolina, 29601

Low Country Rheumatology, PA, Summerville, South Carolina

Status

Completed

Address

Low Country Rheumatology, PA

Summerville, South Carolina, 29486

West Tennessee Research Institute, Jackson, Tennessee

Status

Recruiting

Address

West Tennessee Research Institute

Jackson, Tennessee, 38305

Office of John P. Lavery M.D., PA, Allen, Texas

Status

Completed

Address

Office of John P. Lavery M.D., PA

Allen, Texas, 75013

Tekton Research, Austin, Texas

Status

Recruiting

Address

Tekton Research

Austin, Texas, 78745

Colleyville, Texas

Status

Recruiting

Address

Precision Comprehensive Clinical Research Solutions

Colleyville, Texas, 76034

SouthWest Rheumatology Research, LLC, Mesquite, Texas

Status

Completed

Address

SouthWest Rheumatology Research, LLC

Mesquite, Texas, 75150

Sun Research Institute, LLC, San Antonio, Texas

Status

Recruiting

Address

Sun Research Institute, LLC

San Antonio, Texas, 78215

The University of Texas Health, San Antonio, Texas

Status

Recruiting

Address

The University of Texas Health

San Antonio, Texas, 78229

Swedish Medical Center, Seattle, Washington

Status

Recruiting

Address

Swedish Medical Center

Seattle, Washington, 98104

International Sites

Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina

Status

Recruiting

Address

Hospital General de Agudos Dr. J. M. Ramos Mejia

Ciudad Autonoma Buenos Aires, Buenos Aires, C1221ADC

Mar del Plata, Buenos Aires, Argentina

Status

Recruiting

Address

Centro de Investigaciones Medicas Mar del Plata

Mar del Plata, Buenos Aires, 7600

Mar del Plata, Buenos Aires, Argentina

Status

Recruiting

Address

Policlìnica Red Omip S.A - Ensayos Clinicos GC

Mar del Plata, Buenos Aires, B7600GNY

Centro Dermatologico Schejtman, San Miguel, Buenos Aires, Argentina

Status

Recruiting

Address

Centro Dermatologico Schejtman

San Miguel, Buenos Aires, B1663

APRILLUS Asistencia e Investigacion, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina

Status

Recruiting

Address

APRILLUS Asistencia e Investigacion

Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires, C1406AGA

Buenos Aires, Provincia De Buenos Aires, Argentina

Status

Recruiting

Address

Instituto de Investigaciones Clinicas Quilmes

Buenos Aires, Provincia De Buenos Aires, B1878

Hospital Italiano de La Plata, Buenos Aires, Provincia De Buenos Aires, Argentina

Status

Recruiting

Address

Hospital Italiano de La Plata

Buenos Aires, Provincia De Buenos Aires, B1900

San Miguel de Tucuman, Tucuman, Argentina

Status

Recruiting

Address

Centro de Investigaciones Medicas Tucuman

San Miguel de Tucuman, Tucuman, T4000AXL

Investigaciones Clinicas Tucuman, San Miguel de Tucumán, Tucuman, Argentina

Status

Recruiting

Address

Investigaciones Clinicas Tucuman

San Miguel de Tucumán, Tucuman, T4000ICL

Ciudad Autonoma Buenos Aires, Argentina

Status

Recruiting

Address

Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada

Ciudad Autonoma Buenos Aires, , 1425

STAT Research S.A., Ciudad Autonoma Buenos Aires, Argentina

Status

Recruiting

Address

STAT Research S.A.

Ciudad Autonoma Buenos Aires, , C1013AAB

Ciudad Autonoma Buenos Aires, Argentina

Status

Recruiting

Address

Organizacion Medica de Investigacion (OMI)

Ciudad Autonoma Buenos Aires, , C1015ABO

Ciudad Autonoma Buenos Aires, Argentina

Status

Recruiting

Address

Centro Privado de Medicina Familiar - Mind Out Research

Ciudad Autonoma Buenos Aires, , C1417

Centro Medico Barrio Parque, Ciudad Autonoma de Buenos Aires, Argentina

Status

Recruiting

Address

Centro Medico Barrio Parque

Ciudad Autonoma de Buenos Aires, , C1425

Instituto de Reumatologia, Mendoza, Argentina

Status

Recruiting

Address

Instituto de Reumatologia

Mendoza, , M5500

San Juan, Argentina

Status

Recruiting

Address

CER San Juan Centro Polivalente de Asistencia e Inv. Clinica

San Juan, , 5400

UZ Leuven, Leuven, Belgium

Status

Recruiting

Address

UZ Leuven

Leuven, , 3000

CHU de Liège, Liege, Belgium

Status

Recruiting

Address

CHU de Liège

Liege, , 4000

The Waterside Clinic, Barrie, Ontario, Canada

Status

Recruiting

Address

The Waterside Clinic

Barrie, Ontario, L4M 6L2

Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada

Status

Recruiting

Address

Hamilton Health Sciences Corporation

Hamilton, Ontario, L8V 1C3

The Ottawa Hospital - General Campus, Ottawa, Ontario, Canada

Status

Recruiting

Address

The Ottawa Hospital - General Campus

Ottawa, Ontario, K1H 8L6

Peking Union Medical College Hospital, Beijing, Beijing, China

Status

Recruiting

Address

Peking Union Medical College Hospital

Beijing, Beijing, 100730

Guangzhou, Guangdong, China

Status

Recruiting

Address

Guangdong Second Provincial General Hospital

Guangzhou, Guangdong, 510317

Guangzhou, Guangdong, China

Status

Recruiting

Address

Nanfang Hospital of Southern Medical University

Guangzhou, Guangdong, 510515

Shenzhen People's Hospital, Shenzhen, Guangdong, China

Status

Recruiting

Address

Shenzhen People's Hospital

Shenzhen, Guangdong, 518020

Wuhan, Hubei, China

Status

Recruiting

Address

EC of Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, 430022

Changsha, Hunan, China

Status

Recruiting

Address

Xiangya Hospital, Central South University

Changsha, Hunan, 410008

ZhuZhou Central Hospital, ZhuZhou, Hunan, China

Status

Recruiting

Address

ZhuZhou Central Hospital

ZhuZhou, Hunan, 412000

Nanchang, Jiangxi, China

Status

Recruiting

Address

The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006

Jiangxi Pingxiang People's Hospital, Pingxiang, Jiangxi, China

Status

Recruiting

Address

Jiangxi Pingxiang People's Hospital

Pingxiang, Jiangxi, 337055

The First Hospital of Jilin University, Changchun, Jilin, China

Status

Recruiting

Address

The First Hospital of Jilin University

Changchun, Jilin, 130021

Yanji, Jilin, China

Status

Recruiting

Address

Yanbian University Hospital (Yanbian Hospital)

Yanji, Jilin, 133000

Jiujiang No.1 People's Hospital, Jiujiang, Jiujiang, China

Status

Recruiting

Address

Jiujiang No.1 People's Hospital

Jiujiang, Jiujiang, 332000

Binzhou Medical University Hospital, Binzhou, Shandong, China

Status

Recruiting

Address

Binzhou Medical University Hospital

Binzhou, Shandong, 256603

Shanghai, Shanghai, China

Status

Recruiting

Address

Renji Hospital Shanghai Jiaotong University School of Medicine - West Branch

Shanghai, Shanghai, 200001

Shanghai, Shanghai, China

Status

Recruiting

Address

Ruijin Hospital of Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai, 200011

Chengdu, Sichuan, China

Status

Recruiting

Address

The First Affiliated Hospital of Chengdu Medical College

Chengdu, Sichuan, 610500

Tianjin, Tianjin, China

Status

Recruiting

Address

Tianjin Medical University General Hospital

Tianjin, Tianjin, 300052

Ningbo, Zhejiang, China

Status

Recruiting

Address

The First Affiliated Hospital of Ningbo University

Ningbo, Zhejiang, 315010

Wenzhou People's Hospital, Wenzhou, Zhejiang, China

Status

Recruiting

Address

Wenzhou People's Hospital

Wenzhou, Zhejiang, 325000

Beijing, China

Status

Recruiting

Address

Beijing Chaoyang Hospital, Capital Medical University

Beijing, , 100020

Beijing, China

Status

Recruiting

Address

Xuanwu Hospital Capital Medical University

Beijing, , 100053

Barranquilla, Colombia

Status

Recruiting

Address

Centro de Investigacion Medico Asistencial S.A.S

Barranquilla, , 080020

Clínica de la Costa Ltda., Barranquilla, Colombia

Status

Recruiting

Address

Clínica de la Costa Ltda.

Barranquilla, , 080020

Bogotá, Colombia

Status

Recruiting

Address

Centro de Investigacion en Reumatologia y Especialidades Medicas CIREEM S.A.S.

Bogotá, , 110221

Servimed S.A.S., Bucaramanga, Colombia

Status

Recruiting

Address

Servimed S.A.S.

Bucaramanga, , 680003

IPS Centro Medico Julián Coronel S.A., Cali, Colombia

Status

Recruiting

Address

IPS Centro Medico Julián Coronel S.A.

Cali, , 760001

Preventive Care Ltda, Chia, Colombia

Status

Recruiting

Address

Preventive Care Ltda

Chia, , 250001

Healthy Medical Center, Zipaquirá, Colombia

Status

Recruiting

Address

Healthy Medical Center

Zipaquirá, , 250252

Revmatologie s.r.o., Brno, Czechia

Status

Recruiting

Address

Revmatologie s.r.o.

Brno, , 638 00

Fakultni nemocnice Olomouc, Olomouc, Czechia

Status

Recruiting

Address

Fakultni nemocnice Olomouc

Olomouc, , 77520

Universitaetsmedizin Goettingen, Gottingen, Niedersachsen, Germany

Status

Recruiting

Address

Universitaetsmedizin Goettingen

Gottingen, Niedersachsen, 37075

Medizinische Hochschule Hannover, Hannover, Niedersachsen, Germany

Status

Recruiting

Address

Medizinische Hochschule Hannover

Hannover, Niedersachsen, 30625

Universitaetsklinikum Koeln, Koeln, Nordrhein Westfalen, Germany

Status

Recruiting

Address

Universitaetsklinikum Koeln

Koeln, Nordrhein Westfalen, 50937

Mainz, Rheinland Pfalz, Germany

Status

Recruiting

Address

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz

Mainz, Rheinland Pfalz, 55131

Obudai Egeszsegugyi Centrum Kft., Budapest, Hungary

Status

Recruiting

Address

Obudai Egeszsegugyi Centrum Kft.

Budapest, , 1036

Budapest, Hungary

Status

Recruiting

Address

Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet

Budapest, , 1097

Bekes Varmegyei Kozponti Korhaz, Gyula, Hungary

Status

Recruiting

Address

Bekes Varmegyei Kozponti Korhaz

Gyula, , 5700

Szekesfehervar, Hungary

Status

Recruiting

Address

Vita Verum Medical Egeszsegugyi Szolgaltato Bt.

Szekesfehervar, , 8000

Vital Medical Center, Veszprem, Hungary

Status

Recruiting

Address

Vital Medical Center

Veszprem, , 8200

Rambam Health Care Center, Haifa, Israel

Status

Recruiting

Address

Rambam Health Care Center

Haifa, , 3109601

Meir Medical Center, Kfar- Sava, Israel

Status

Recruiting

Address

Meir Medical Center

Kfar- Sava, , 4428164

Rabin Medical Center-Beilinson Campus, Petach-Tikva, Israel

Status

Recruiting

Address

Rabin Medical Center-Beilinson Campus

Petach-Tikva, , 4941492

Chaim Sheba Medical Center, Ramat Gan, Israel

Status

Recruiting

Address

Chaim Sheba Medical Center

Ramat Gan, , 5262001

Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Status

Recruiting

Address

Tel Aviv Sourasky Medical Center

Tel Aviv, , 64239

Istituto Clinico Humanitas, Rozzano, Milano, Italy

Status

Completed

Address

Istituto Clinico Humanitas

Rozzano, Milano, 20089

Rome, Roma, Italy

Status

Recruiting

Address

Azienda Ospedaliera San Camillo Forlanini

Rome, Roma, 00151

Ospedale M. Scarlato, Scafati, Salerno, Italy

Status

Recruiting

Address

Ospedale M. Scarlato

Scafati, Salerno, 84018

Brescia, Italy

Status

Recruiting

Address

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)

Brescia, , 25123

Azienda Ospedaliera di Padova, Padova, Italy

Status

Recruiting

Address

Azienda Ospedaliera di Padova

Padova, , 35100

Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

Status

Recruiting

Address

Azienda Ospedaliero Universitaria Pisana

Pisa, , 56100

Università Campus Bio-Medico di Roma, Roma, Italy

Status

Recruiting

Address

Università Campus Bio-Medico di Roma

Roma, , 00155

Roma, Italy

Status

Recruiting

Address

Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza

Roma, , 00161

JCHO Chukyo Hospital, Nagoya-shi, Aichi-Ken, Japan

Status

Recruiting

Address

JCHO Chukyo Hospital

Nagoya-shi, Aichi-Ken, 457-8510

Fujita Health University Hospital, Toyoake-shi, Aichi-Ken, Japan

Status

Recruiting

Address

Fujita Health University Hospital

Toyoake-shi, Aichi-Ken, 470-1192

NHO Chibahigashi National Hospital, Chiba-shi, Chiba-Ken, Japan

Status

Recruiting

Address

NHO Chibahigashi National Hospital

Chiba-shi, Chiba-Ken, 260-8712

Chibaken Saiseikai Narashino Hospital, Narashino-shi, Chiba-Ken, Japan

Status

Recruiting

Address

Chibaken Saiseikai Narashino Hospital

Narashino-shi, Chiba-Ken, 275-8580

KKR Hamanomachi Hospital, Fukuoka-shi, Fukuoka-Ken, Japan

Status

Recruiting

Address

KKR Hamanomachi Hospital

Fukuoka-shi, Fukuoka-Ken, 810-8539

NHO Kyushu Medical Center, Fukuoka-shi, Fukuoka-Ken, Japan

Status

Recruiting

Address

NHO Kyushu Medical Center

Fukuoka-shi, Fukuoka-Ken, 810-8563

Kitakyushu-shi, Fukuoka-Ken, Japan

Status

Recruiting

Address

Hospital of the University of Occupational and Environmental Health, Japan

Kitakyushu-shi, Fukuoka-Ken, 807-8556

Hiroshima University Hospital, Hiroshima-shi, Hiroshima-Ken, Japan

Status

Recruiting

Address

Hiroshima University Hospital

Hiroshima-shi, Hiroshima-Ken, 734-8551

Tonan Hospital, Sapporo-shi, Hokkaido, Japan

Status

Recruiting

Address

Tonan Hospital

Sapporo-shi, Hokkaido, 060-0004

Himeji-shi, Hyogo-Ken, Japan

Status

Recruiting

Address

Japanese Red Cross Society Himeji Hospital

Himeji-shi, Hyogo-Ken, 670-8540

Kobe University Hospital, Kobe-shi, Hyogo-Ken, Japan

Status

Recruiting

Address

Kobe University Hospital

Kobe-shi, Hyogo-Ken, 650-0017

Kobe-shi, Hyogo-Ken, Japan

Status

Recruiting

Address

Kobe City Hospital Organization Kobe City Medical Center General Hospital

Kobe-shi, Hyogo-Ken, 650-0047

Kagawa University Hospital, Kita-gun, Kagawa-ken, Japan

Status

Recruiting

Address

Kagawa University Hospital

Kita-gun, Kagawa-ken, 761-0793

St. Mariana University Hospital, Kawasaki-shi, Kanagawa-ken, Japan

Status

Recruiting

Address

St. Mariana University Hospital

Kawasaki-shi, Kanagawa-ken, 216-8511

Kitasato University Hospital, Sagamihara-shi, Kanagawa-Ken, Japan

Status

Recruiting

Address

Kitasato University Hospital

Sagamihara-shi, Kanagawa-Ken, 252-0375

Yokohama City University Medical Center, Yokohama-shi, Kanagawa-Ken, Japan

Status

Recruiting

Address

Yokohama City University Medical Center

Yokohama-shi, Kanagawa-Ken, 232-0024

Japanese Red Cross Kumamoto Hospital, Kumamoto-shi, Kumamoto-Ken, Japan

Status

Recruiting

Address

Japanese Red Cross Kumamoto Hospital

Kumamoto-shi, Kumamoto-Ken, 861-8520

Tohoku University Hospital, Sendai-shi, Miyagi-Ken, Japan

Status

Recruiting

Address

Tohoku University Hospital

Sendai-shi, Miyagi-Ken, 980-8574

NHO Osaka Minami Medical Center, Kawachinagano-shi, Osaka-Fu, Japan

Status

Recruiting

Address

NHO Osaka Minami Medical Center

Kawachinagano-shi, Osaka-Fu, 586-8521

Osaka-shi, Osaka-Fu, Japan

Status

Recruiting

Address

Tazuke-kofukai Medical Research Institute Kitano Hospital

Osaka-shi, Osaka-Fu, 530-8480

Kindai University Hospital, Osakasayama-shi, Osaka-Fu, Japan

Status

Recruiting

Address

Kindai University Hospital

Osakasayama-shi, Osaka-Fu, 589-8511

Takatsuki-shi, Osaka-Fu, Japan

Status

Recruiting

Address

Osaka Medical and Pharmaceutical University Hospital

Takatsuki-shi, Osaka-Fu, 569-8686

Saitama Medical University Hospital, Iruma-gun, Saitama-Ken, Japan

Status

Recruiting

Address

Saitama Medical University Hospital

Iruma-gun, Saitama-Ken, 350-0495

Bunkyo-ku, Tokyo-To, Japan

Status

Recruiting

Address

Tokyo Medical and Dental University Hospital

Bunkyo-ku, Tokyo-To, 113-8519

St. Luke's International Hospital, Chuo-ku, Tokyo-To, Japan

Status

Recruiting

Address

St. Luke's International Hospital

Chuo-ku, Tokyo-To, 104-8560

Nihon University Itabashi Hospital, Itabashi-ku, Tokyo-To, Japan

Status

Recruiting

Address

Nihon University Itabashi Hospital

Itabashi-ku, Tokyo-To, 173-8610

Toho University Ohashi Medical Center, Meguro-ku, Tokyo-To, Japan

Status

Recruiting

Address

Toho University Ohashi Medical Center

Meguro-ku, Tokyo-To, 153-8515

Toho University Omori Medical Center, Ota-ku, Tokyo-To, Japan

Status

Recruiting

Address

Toho University Omori Medical Center

Ota-ku, Tokyo-To, 143-8541

Keio University Hospital, Shinjuku-ku, Tokyo-To, Japan

Status

Recruiting

Address

Keio University Hospital

Shinjuku-ku, Tokyo-To, 160-8582

Shinjuku-ku, Tokyo-To, Japan

Status

Recruiting

Address

Center Hospital of the National Center for Global Health and Medicine

Shinjuku-ku, Tokyo-To, 162-8655

Amsterdam UMC, Locatie VUMC, Amsterdam, Netherlands

Status

Recruiting

Address

Amsterdam UMC, Locatie VUMC

Amsterdam, , 1081 HV

Universitair Medisch Centrum Groningen, Groningen, Netherlands

Status

Recruiting

Address

Universitair Medisch Centrum Groningen

Groningen, , 9713 GZ

UMC Utrecht, Utrecht, Netherlands

Status

Recruiting

Address

UMC Utrecht

Utrecht, , 3584 CX

Centro Reumatologico, Caguas, Puerto Rico

Status

Recruiting

Address

Centro Reumatologico

Caguas, , 00725

Brasov, Romania

Status

Recruiting

Address

S.C Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L

Brasov, , 500283

S.C Dental Health Care SRL, Bucuresti, Romania

Status

Recruiting

Address

S.C Dental Health Care SRL

Bucuresti, , 014142

Cluj-Napoca, Romania

Status

Recruiting

Address

Spitalul Clinic Judetean de Urgenta Cluj Napoca

Cluj-Napoca, , 400006

S.C.Centrul Medical Unirea SRL, Iasi, Romania

Status

Recruiting

Address

S.C.Centrul Medical Unirea SRL

Iasi, , 700023

Suceava, Romania

Status

Recruiting

Address

Spitalul Judetean de Urgenta "Sf. Ioan cel Nou" Suceava

Suceava, , 720284

S.C Centrul Medical Unirea SRL, Targu Mures, Romania

Status

Recruiting

Address

S.C Centrul Medical Unirea SRL

Targu Mures, , 540136

Institute of Rheumatology, Belgrade, Serbia

Status

Recruiting

Address

Institute of Rheumatology

Belgrade, , 11000

Institute of Rheumatology, Belgrade, Serbia

Status

Recruiting

Address

Institute of Rheumatology

Belgrade, , 11000

Institute of Rheumatology, Belgrade, Serbia

Status

Recruiting

Address

Institute of Rheumatology

Belgrade, , 11000

University Clinical Center of Serbia, Belgrade, Serbia

Status

Recruiting

Address

University Clinical Center of Serbia

Belgrade, , 11000

Clinical Hospital Center Bezanijska kosa, Belgrade, Serbia

Status

Recruiting

Address

Clinical Hospital Center Bezanijska kosa

Belgrade, , 11080

Niska Banja, Serbia

Status

Recruiting

Address

Institute of Treatment and Rehabilitation "Niska Banja"

Niska Banja, , 18205

Whipps Cross University Hospital, London, Greater London, United Kingdom

Status

Recruiting

Address

Whipps Cross University Hospital

London, Greater London, E11 1NR

Guy's Hospital, London, Greater London, United Kingdom

Status

Recruiting

Address

Guy's Hospital

London, Greater London, SE1 9RT

Doncaster Royal Infirmary, Doncaster, South Yorkshire, United Kingdom

Status

Recruiting

Address

Doncaster Royal Infirmary

Doncaster, South Yorkshire, DN2 5LT

Cannock Chase Hospital, Cannock, Staffordshire, United Kingdom

Status

Recruiting

Address

Cannock Chase Hospital

Cannock, Staffordshire, WS11 5XY