A Multicenter Trial to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of HZN-825 in Patients With Diffuse Cutaneous Systemic Sclerosis

Study Purpose

This is a randomized, double-blind, placebo-controlled, repeat-dose, multicenter trial. Participants will be screened within 4 weeks prior to the Baseline (Day 1) Visit. Approximately 300 participants who meet the trial eligibility criteria will be randomized on Day 1 in a 1:1:1 ratio to receive HZN-825 300 mg QD, HZN-825 300 mg BID or placebo for 52 weeks. The trial will include up to a 4-week Screening Period and a 52-week Double-blind Treatment Period. Participants will take their first dose of trial drug at the clinic and will return to the clinic for trial visits at Week 4 and every 6 weeks thereafter until Week 52. All participants who complete the Double-blind Treatment Period (Week 52) will be eligible to enter a 52-week extension trial (HZNP-HZN-825-302, NCT not available yet). Participants not entering the extension will return to the clinic for a Safety Follow-up Visit 4 weeks after the last dose of trial drug.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years - 75 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

1. Written informed consent. 2. Male or female between the ages of 18 and 75 years, inclusive, at Screening. 3. Meets the 2013 American College of Rheumatology/European League Against Rheumatism classification criteria for SSc with a total score of ≥9 (Van den Hoogen et al., 2013). 4. Classified as having skin involvement proximal to the elbow and knee (diffuse cutaneous SSc subset by LeRoy and Medsger, 2001). 5. At the time of enrollment, less than 36 months since the onset of the first SSc manifestation, other than Raynaud's phenomenon. 6. Skin thickening from SSc in the forearm suitable for repeat biopsy. 7. mRSS units ≥15 at Screening. 8. FVC ≥45% predicted at Screening, as determined by spirometry. 9. Willing and able to comply with the prescribed treatment protocol and evaluations for the duration of the trial.

Exclusion Criteria:

1. Positive for anti-centromere antibodies. 2. Diagnosed with sine scleroderma or limited cutaneous SSc. 3. Diagnosed with other autoimmune connective tissue diseases, except for fibromyalgia, scleroderma-associated myopathy and secondary Sjogren's syndrome. 4. Scleroderma renal crisis diagnosed within 6 months of the Screening Visit. 5. Any of the following cardiovascular diseases: 1. uncontrolled, severe hypertension (≥160/100 mmHg) or persistent low blood pressure (systolic blood pressure <90 mmHg) within 6 months of Screening, 2. myocardial infarction within 6 months of Screening, 3. unstable cardiac angina within 6 months of Screening. 6. DLCO <40% predicted (corrected for hemoglobin). If severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure is of clinical concern for any subject, consider using a DLCO up to 6 months before the Screening Visit. 7. Pulmonary arterial hypertension (PAH) by right heart catheterization requiring treatment with more than 1 oral PAH-approved therapy or any parenteral therapy. Treatment is allowed for erectile dysfunction and/or Raynaud's phenomenon/digital ulcers. 8. Corticosteroid use for conditions other than SSc within 4 weeks prior to Screening (topical steroids for dermatological conditions and inhaled/intranasal/intra-articular steroids are allowed). 9. Use of any other non-steroid immunosuppressive agent, small biologic molecule, cytotoxic or anti-fibrotic drug within 4 weeks of Screening, including cyclophosphamide, azathioprine (Imuran®) or other immunosuppressive or cytotoxic medication. Exceptions include mycophenolate mofetil (CellCept®), mycophenolic acid (Myfortic®), methotrexate and low-dose prednisone, as follows: use of CellCept ≤3 g/day, Myfortic ≤2.14 g/day, methotrexate ≤15 mg/week and prednisone ≤10 mg/day (or equivalent dosing of glucocorticoids) is allowed. See Table 9.1 for full details. Subjects taking CellCept, Myfortic or methotrexate must have been doing so for ≥6 months and the dose must have been stable for ≥16 weeks prior to the Day 1 Visit. Prednisone must have been at a stable dose for ≥8 weeks prior to the Day 1 Visit. It is acceptable to be on background low-dose prednisone and anti-malarial drug along with CellCept, Myfortic or methotrexate. Rituximab must not have been used within 6 months of the Day 1 Visit. 10. Known active bacterial, viral, fungal, mycobacterial or other infection, including tuberculosis or atypical mycobacterial disease (fungal infections of nail beds are allowed). 11. Use of a United States Food and Drug Administration-approved agent for SSc or an investigational agent for any condition within 90 days or 5 half-lives, whichever is longer, prior to Screening or anticipated use during the course of the trial. 12. Malignant condition in the past 5 years (except successfully treated basal/squamous cell carcinoma of the skin or cervical cancer in situ). 13. Women of childbearing potential or male subjects not agreeing to use highly effective method(s) of birth control throughout the trial and for 1 month after last dose of trial drug. Male subjects must refrain from sperm donation and females from egg/ova donation for this same time period. 14. Pregnant or lactating women. 15. Current drug or alcohol abuse or history of either within the previous 2 years, in the opinion of the Investigator or as reported by the subject. 16. Previous enrollment in this trial or participation in a prior HZN-825 or SAR100842 clinical trial. 17. Known history of positive test for human immunodeficiency virus. 18. Active hepatitis (hepatitis B: positive hepatitis B surface antigen and positive anti-hepatitis B core antibody [anti-HBcAb] and negative hepatitis B surface antibody [HBsAb] or positive for HBcAb with a positive test for HBsAb and with presence of hepatitis B virus DNA at Screening; hepatitis C: positive anti-hepatitis C virus [anti-HCV] and positive RNA HCV). 19. Current alcoholic liver disease, primary biliary cirrhosis or primary sclerosing cholangitis. 20. Previous organ transplant (including allogeneic and autologous marrow transplant). 21. International normalized ratio >2, prolonged prothrombin time >1.5 × the upper limit of normal (ULN) or partial thromboplastin time >1.5 × ULN at Screening. 22. Alanine aminotransferase or aspartate aminotransferase >2 × ULN. 23. Estimated glomerular filtration rate <30 mL/min/1.73 m^2 at Screening. 24. Total bilirubin >2 × ULN. Subjects with documented diagnosis of Gilbert's syndrome may be enrolled if their total bilirubin is ≤3.0 mg/dL. 25. Any other condition that, in the opinion of the Investigator, would preclude enrollment in the trial.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04781543
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Horizon Therapeutics Ireland DAC
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Farah Ali, MD
Principal Investigator Affiliation Horizon Therapeutics
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Austria, France, Germany, Greece, Israel, Italy, Japan, Korea, Republic of, Mexico, Netherlands, Poland, Portugal, Spain, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Diffuse Cutaneous Systemic Sclerosis, Sclerosis, Systemic
Arms & Interventions

Arms

Experimental: HZN-825 300 mg once daily (QD)

300mg oral tablets given in the morning and placebo in the evening

Experimental: HZN-825 300 mg twice daily (BID)

300mg oral tablets given in the morning and evening

Placebo Comparator: Placebo

Placebo will be given orally in the morning and evening

Interventions

Drug: - HZN-825 BID

300 mg oral tablets BID

Drug: - Placebo

Placebo BID

Drug: - HZN-825 QD

300 mg oral tablets QD

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Phoenix, Arizona

Status

Recruiting

Address

Arizona Arthritis and Rheumatology Research, PLLC

Phoenix, Arizona, 85032

Site Contact

Mandee Lochridge

[email protected]

480-626-6637

Pacific Arthritis Care Center, Los Angeles, California

Status

Recruiting

Address

Pacific Arthritis Care Center

Los Angeles, California, 90045

Site Contact

Stanique Thomas

[email protected]

310-297-6812

UCLA Department of Medicine, Los Angeles, California

Status

Recruiting

Address

UCLA Department of Medicine

Los Angeles, California, 90095-1670

Site Contact

Nancy Lopez

[email protected]

310-794-6213

Stanford University School of Medicine, Palo Alto, California

Status

Recruiting

Address

Stanford University School of Medicine

Palo Alto, California, 94304

Site Contact

Puneet Kapoor

[email protected]

818-350-5053

Miami, Florida

Status

Recruiting

Address

University of Miami Miller School of Medicine

Miami, Florida, 33136

Site Contact

Bethly Aubourg

[email protected]

305-243-8567

IRIS Research and Development LLC, Plantation, Florida

Status

Recruiting

Address

IRIS Research and Development LLC

Plantation, Florida, 33324

Site Contact

Jhon Galindo

[email protected]

954-476-2338

DelRicht Clinical Research, LLC, New Orleans, Louisiana

Status

Recruiting

Address

DelRicht Clinical Research, LLC

New Orleans, Louisiana, 70115

Site Contact

Katie Giorlando

[email protected]

504-336-2667

Boston University School Of Medicine, Boston, Massachusetts

Status

Recruiting

Address

Boston University School Of Medicine

Boston, Massachusetts, 02118-2642

Site Contact

Kimberly Finch

[email protected]

617-358-6785

Michigan Medicine University of Michigan, Ann Arbor, Michigan

Status

Recruiting

Address

Michigan Medicine University of Michigan

Ann Arbor, Michigan, 48109

Site Contact

Sara Jaafar

[email protected]

734-936-2625

Mayo Clinic - Cancer Center, Rochester, Minnesota

Status

Recruiting

Address

Mayo Clinic - Cancer Center

Rochester, Minnesota, 55905

Site Contact

Shirley-Ann Osei Onomah

[email protected]

507-284-4797

Duke University Medical Center, Durham, North Carolina

Status

Recruiting

Address

Duke University Medical Center

Durham, North Carolina, 27713

Site Contact

Gary McDaniel

[email protected]

919-681-5871

Medical University of South Carolina, Charleston, South Carolina

Status

Recruiting

Address

Medical University of South Carolina

Charleston, South Carolina, 29425-8900

Site Contact

Brittany Fraiser

[email protected]

843-792-8613

Metroplex Clinical Research Center, Dallas, Texas

Status

Recruiting

Address

Metroplex Clinical Research Center

Dallas, Texas, 75231

Site Contact

Tri Nguyen

[email protected]

214-879-6737

UT Physicians Rheumatology, Houston, Texas

Status

Recruiting

Address

UT Physicians Rheumatology

Houston, Texas, 77030

Site Contact

Patricia Gonzales

[email protected]

713-500-7118

International Sites

Framingham Centro Médico, La Plata, Buenos Aires, Argentina

Status

Recruiting

Address

Framingham Centro Médico

La Plata, Buenos Aires, B1902COS

Site Contact

Paula Bordoni

[email protected]

866-479-6742

Consultorios Médicos Dr. Catalán Pellet, Recoleta, Ciudad Autónoma De BuenosAires, Argentina

Status

Recruiting

Address

Consultorios Médicos Dr. Catalán Pellet

Recoleta, Ciudad Autónoma De BuenosAires, C1111AAL

Site Contact

Fernando Gomez

[email protected]

866-479-6742

San Miguel de Tucuman, Tucumán, Argentina

Status

Recruiting

Address

Centro de Investigaciones Médicas Tucumán

San Miguel de Tucuman, Tucumán, T4000AXL

Site Contact

Maria Florencia Montesinos

[email protected]

866-479-6742

San Miguel De Tucumán, Tucumán, Argentina

Status

Recruiting

Address

Consultorio de Investigaciones Reumatologicas

San Miguel De Tucumán, Tucumán, T4000AXL

Site Contact

Hugo Medina

[email protected]

866-479-6742

Clinica Mayo de U.M.C.B. S.R.L, San Miguel de Tucumán, Tucumán, Argentina

Status

Recruiting

Address

Clinica Mayo de U.M.C.B. S.R.L

San Miguel de Tucumán, Tucumán, T4000

Site Contact

Laura De la Rosa

[email protected]

866-479-6742

Organización Médica de Investigación, Ciudad Autónoma de Buenos Aires, Argentina

Status

Recruiting

Address

Organización Médica de Investigación

Ciudad Autónoma de Buenos Aires, , C1015

Site Contact

Oriana Vines

[email protected]

866-479-6742

Ciudad Autónoma de Buenos Aires, Argentina

Status

Recruiting

Address

Aprillus Asistencia e Investigacion de Arcis Salud SRL

Ciudad Autónoma de Buenos Aires, , C1406AGA

Site Contact

Miguel Angel Vallejo

[email protected]

+541149512763

Consultorio Médico Dra. Rivera, Ciudad Autónoma de Buenos Aires, Argentina

Status

Recruiting

Address

Consultorio Médico Dra. Rivera

Ciudad Autónoma de Buenos Aires, , C1426

Site Contact

Cristina Rillo

[email protected]

866-479-6742

Clínica Adventista Belgrano, Ciudad Autónoma de Buenos Aires, Argentina

Status

Recruiting

Address

Clínica Adventista Belgrano

Ciudad Autónoma de Buenos Aires, , C1430

Site Contact

Lucia Beloqui

[email protected]

866-479-6742

I.R. Medical Center - Hospital de Dia, Mendoza, Argentina

Status

Recruiting

Address

I.R. Medical Center - Hospital de Dia

Mendoza, , M5500CPH

Site Contact

Hebe Regazzoni

[email protected]

+542614257028

Medizinische Universität Graz, Graz, Steiermark, Austria

Status

Recruiting

Address

Medizinische Universität Graz

Graz, Steiermark, 8010

Site Contact

Angelika Lackner

[email protected]

+4331638516856

Hôpitaux Universitaires de Strasbourg, Strasbourg, Bas-Rhin, France

Status

Recruiting

Address

Hôpitaux Universitaires de Strasbourg

Strasbourg, Bas-Rhin, 67000

Site Contact

Thouma-La Chanthavinout

[email protected]

866-479-6742

Bordeaux, Gironde, France

Status

Recruiting

Address

Centre Hospitalier Universitaire de Bordeaux, Hopital Pellegrin

Bordeaux, Gironde, 33000

Site Contact

Justine Landrin

[email protected]

866-479-6742

Hôpital de Rangueil, Toulouse, Haute-Garonne, France

Status

Recruiting

Address

Hôpital de Rangueil

Toulouse, Haute-Garonne, 31000

Site Contact

Gregory Pugnet

[email protected]

+33561772278

Hôpital Claude Huriez, Lille, Nord, France

Status

Recruiting

Address

Hôpital Claude Huriez

Lille, Nord, 59000

Site Contact

Quentin Ducrocq

[email protected]

+33320445048

Hopital Cochin, Paris, France

Status

Recruiting

Address

Hopital Cochin

Paris, , 75014

Site Contact

Yannick Allanore, MD

[email protected]

+33158412563

Charité - Universitätsmedizin Berlin, Berlin, Germany

Status

Recruiting

Address

Charité - Universitätsmedizin Berlin

Berlin, , 10117

Site Contact

Jan Zernicke

[email protected]

+4930450513227

Laiko General Hospital of Athens, Athens, Attiki, Greece

Status

Recruiting

Address

Laiko General Hospital of Athens

Athens, Attiki, 115 27

Site Contact

Lily Bournia

[email protected]

+306977150292

Kianous Stavros, Thessaloniki, Greece

Status

Recruiting

Address

Kianous Stavros

Thessaloniki, , 546 36

Site Contact

Evangelia Mpliakou

[email protected]

866-479-6742

Thessaloniki, Greece

Status

Recruiting

Address

Ippokratio General Hospital of Thessaloniki

Thessaloniki, , 564 29

Site Contact

Theodoros Dimitroulas

[email protected]

+302310892169

Meir Medical Center, Kfar Sava, HaMerkaz, Israel

Status

Recruiting

Address

Meir Medical Center

Kfar Sava, HaMerkaz, 44281

Site Contact

Eran Levi

[email protected]

+97297471936

Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Tel-Aviv, Israel

Status

Recruiting

Address

Tel Aviv Sourasky Medical Center

Tel Aviv-Yafo, Tel-Aviv, 64239

Site Contact

Irena Litinsky

[email protected]

+97236973668

Rambam Medical Center, Haifa, Israel

Status

Recruiting

Address

Rambam Medical Center

Haifa, , 31096

Site Contact

Alexandra Balbir-Gurman

[email protected]

+97247772268

Lady Davis Carmel Medical Center, Haifa, Israel

Status

Recruiting

Address

Lady Davis Carmel Medical Center

Haifa, , 34362

Site Contact

Devy Zisman

[email protected]

+97248250486

Rabin Medical Center, Petah tikva, Israel

Status

Recruiting

Address

Rabin Medical Center

Petah tikva, , 49100

Site Contact

Yair Molad

[email protected]

+97239376947

Sheba Medical Center, Tel HaShomer, Israel

Status

Recruiting

Address

Sheba Medical Center

Tel HaShomer, , 52621

Site Contact

Merav Lidar

[email protected]

+972544721675

Roma, Lazio, Italy

Status

Recruiting

Address

Fondazione Policlinico Universitario A Gemelli

Roma, Lazio, 00168

Site Contact

Maria Antonia Pirro

[email protected]

+393385351173

Pavia, Lombardia, Italy

Status

Recruiting

Address

Fondazione IRCCS Policlinico San Matteo di Pavia

Pavia, Lombardia, 27100

Site Contact

Carlomaurizio Montecucco

[email protected]

+390382501878

Istituto Clinico Humanitas, Rozzano, Lombardia, Italy

Status

Recruiting

Address

Istituto Clinico Humanitas

Rozzano, Lombardia, 20089

Site Contact

Carlo Selmi

[email protected]

+390282245129

Firenze, Toscana, Italy

Status

Recruiting

Address

Azienda Ospedaliera Universitaria Careggi

Firenze, Toscana, 50141

Site Contact

Francesca Nacci

[email protected]

+393482920658

Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

Status

Recruiting

Address

Azienda Ospedaliero Universitaria Pisana

Pisa, , 56126

Site Contact

Marta Mosca

[email protected]

+39050558603

Fujita Health University Hospital, Toyoake-shi, Aiti, Japan

Status

Recruiting

Address

Fujita Health University Hospital

Toyoake-shi, Aiti, 470-1192

Site Contact

Tomomi Nakanishi

[email protected]

+819035438861

Sapporo Medical University Hospital, Sapporo-Shi, Hokkaidô, Japan

Status

Recruiting

Address

Sapporo Medical University Hospital

Sapporo-Shi, Hokkaidô, 060-0061

Site Contact

Aya Kanno

[email protected]

+818057229259

Kumamoto University Hospital, Kumamoto-Shi, Kumamoto, Japan

Status

Recruiting

Address

Kumamoto University Hospital

Kumamoto-Shi, Kumamoto, 860-0811

Site Contact

Masao Matsuoka, MD

[email protected]

+81963442111

Saitama Medical University Hospital, Iruma-Gun, Saitama, Japan

Status

Recruiting

Address

Saitama Medical University Hospital

Iruma-Gun, Saitama, 350-0495

Site Contact

Yuki Kubo

[email protected]

+81486505302

Kitasato University Medical Center, Kitamoto-Shi, Saitama, Japan

Status

Recruiting

Address

Kitasato University Medical Center

Kitamoto-Shi, Saitama, 364-0026

Site Contact

Sumiaki Tanaka

[email protected]

+81485937390

St. Luke's International Hospital, Tokyo, Japan

Status

Recruiting

Address

St. Luke's International Hospital

Tokyo, , 104-8560

Site Contact

Mayumi Hirayama

[email protected]

+81355507158

Nippon Medical School Hospital, Tokyo, Japan

Status

Recruiting

Address

Nippon Medical School Hospital

Tokyo, , 113-8603

Site Contact

Naomi Takamura

[email protected]jp

+81358146247

Seongnam, Gyeonggido, Korea, Republic of

Status

Recruiting

Address

Seoul National University Bundang Hospital

Seongnam, Gyeonggido, 13620

Site Contact

Sun Ho Kim

[email protected]

866-479-6742

Chonnam National University Hospital, Gwangju, Korea, Republic of

Status

Recruiting

Address

Chonnam National University Hospital

Gwangju, , 61469

Site Contact

Bo-Ram Park

[email protected]

866-479-6742

Hanyang University Medical Center, Seoul, Korea, Republic of

Status

Recruiting

Address

Hanyang University Medical Center

Seoul, , 4763

Site Contact

Hee Jeong Kim

[email protected]

866-479-6742

Seoul, Korea, Republic of

Status

Recruiting

Address

Gangnam Severance Hospital, Yonsei University Health System

Seoul, , 6273

Site Contact

Jiwoo Choi

[email protected]

866-479-6742

Ciudad de México, Distrito Federal, Mexico

Status

Recruiting

Address

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Ciudad de México, Distrito Federal, 14080

Site Contact

Cristina Paredes

[email protected]

+525558467831

Mexico, Distrito Federal, Mexico

Status

Recruiting

Address

CITER, Centro de Investigacion y Tratamiento de las Enfermedades Reumaticas SA de CV

Mexico, Distrito Federal, 6700

Site Contact

Gabriel Medrano-Ramirez

[email protected]

+525555334180

Miguel Hidalgo, Distrito Federal, Mexico

Status

Recruiting

Address

Centro de Investigación y Tratamiento Reumatológico S.C

Miguel Hidalgo, Distrito Federal, 11850

Site Contact

Fedra Irazoque-Palazuelos

[email protected]

+525526143031

Guadalajara, Jalisco, Mexico

Status

Recruiting

Address

Centro de Estudios de Investigacion Basica Y Clinica SC

Guadalajara, Jalisco, 44690

Site Contact

Arturo Ramirez Rivas

[email protected]

+523336300946

Centro Integral Reumatologia SA de CV, Guadalajara, Jalisco, Mexico

Status

Recruiting

Address

Centro Integral Reumatologia SA de CV

Guadalajara, Jalisco, ZC 44160

Site Contact

Luz Maria Ruelas

[email protected]

+523312020959

Burócratas del Estado, San Luis Potosí, Mexico

Status

Recruiting

Address

Centro de Alta Especialidad En Reumatologia E Investigacion Del Potosi SC

Burócratas del Estado, San Luis Potosí, 78213

Site Contact

Rodrigo Martinez de la Luz

[email protected]

+524448084352

Merida, Yucatán, Mexico

Status

Recruiting

Address

Unidad de Atencion Medica e Investigacion en Salud

Merida, Yucatán, 97000

Site Contact

Daniela Beatriz Pat Cruz

[email protected]

+529992110094

Guadalajara, Mexico

Status

Recruiting

Address

Clinica de Investigacion en Reumatologia y Obesidad

Guadalajara, , 44650

Site Contact

Sergio Duran-Barragan

[email protected]

+523331200700

Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands

Status

Recruiting

Address

Leids Universitair Medisch Centrum

Leiden, Zuid-Holland, 2333 ZA

Site Contact

Jessica Vlot

[email protected]

+31715263592

Universitair Medisch Centrum Groningen, Groningen, Netherlands

Status

Recruiting

Address

Universitair Medisch Centrum Groningen

Groningen, , 9713 GZ

Site Contact

Ellis Herder

[email protected]

+31503618031

Twoja Przychodnia NCM, Nowa Sól, Lubuskie, Poland

Status

Recruiting

Address

Twoja Przychodnia NCM

Nowa Sól, Lubuskie, 67-100

Site Contact

Jakub Dec

[email protected]

+48669009333

Warszawa, Mazowieckie, Poland

Status

Recruiting

Address

Medicover Integrated Clinical Services sp. z o.o

Warszawa, Mazowieckie, 00-874

Site Contact

Marta Jeka

[email protected]

+48226291354

Poznan, Wielkopolskie, Poland

Status

Recruiting

Address

Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi

Poznan, Wielkopolskie, 61-545

Site Contact

Magdalena Richter

[email protected]

+48618310119

MCM Krakow - PRATIA, Kraków, Poland

Status

Recruiting

Address

MCM Krakow - PRATIA

Kraków, , 30-510

Site Contact

Agnieszka Kasprzyk

[email protected]

+48122954144

Hospital Garcia de Orta, Almada, Setúbal, Portugal

Status

Recruiting

Address

Hospital Garcia de Orta

Almada, Setúbal, 2805-267

Site Contact

Ana Sofia Marques

[email protected]

866-479-6742

Hospital de Braga, Braga, Portugal

Status

Recruiting

Address

Hospital de Braga

Braga, , 4710-243

Site Contact

Mariana Bernardo

[email protected]

+351937374562

Coimbra, Portugal

Status

Recruiting

Address

Centro Hospitalar E Universitário de Coimbra EPE

Coimbra, , 3000-459

Site Contact

Ruben Fernandes

[email protected]

+351239400547

Lisboa, Portugal

Status

Recruiting

Address

Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria

Lisboa, , 1649-035

Site Contact

Sónia Figueiredo

[email protected]

+351210405814

Ponte De Lima, Portugal

Status

Recruiting

Address

Hospital Conde de Bertiandos Unidade Local de Saúde Do Alto Minho

Ponte De Lima, , 4990-041

Site Contact

Helena Pires

[email protected]

866-479-6742

Centro Hospitalar de São João, E.P.E., Porto, Portugal

Status

Recruiting

Address

Centro Hospitalar de São João, E.P.E.

Porto, , 4200-319

Site Contact

Eduarda Gonçalves

[email protected]

866-479-6742

Hospital de Merida, Merida, Badajoz, Spain

Status

Recruiting

Address

Hospital de Merida

Merida, Badajoz, 6800

Site Contact

Eugenio Chamizo Carmona

[email protected]

+34636419101

Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona, Spain

Status

Recruiting

Address

Corporacio Sanitaria Parc Tauli

Sabadell, Barcelona, 8208

Site Contact

Alejandra Serrano

[email protected]

+34937231010 #24065

C.H. Regional Reina Sofia, Cordoba, Córdoba, Spain

Status

Recruiting

Address

C.H. Regional Reina Sofia

Cordoba, Córdoba, 14004

Site Contact

Maria de Carmen Abalos Aguilera

[email protected]

+34957011631

Hospital Universitario A Coruña, a Coruña, Spain

Status

Recruiting

Address

Hospital Universitario A Coruña

a Coruña, , 15006

Site Contact

Emma Rodriguez Rodriguez

[email protected]

+34981176117

Hospital Universitario Vall d'Hebron, Barcelona, Spain

Status

Recruiting

Address

Hospital Universitario Vall d'Hebron

Barcelona, , 008035

Site Contact

Karen Lorite Gomez

[email protected]

+34934893000

Hospital de La Santa Creu i Sant Pau, Barcelona, Spain

Status

Recruiting

Address

Hospital de La Santa Creu i Sant Pau

Barcelona, , 8025

Site Contact

Ivan Castellvi Barranco

[email protected]

+34934552331

Hospital Quironsalud Infanta Luisa, Sevilla, Spain

Status

Recruiting

Address

Hospital Quironsalud Infanta Luisa

Sevilla, , 41010

Site Contact

Alfonso Pastor

[email protected]

+34954001876

Hospital Universitario Virgen del Rocio, Sevilla, Spain

Status

Recruiting

Address

Hospital Universitario Virgen del Rocio

Sevilla, , 41013

Site Contact

Alejandro Muñoz Jimenez

[email protected]

+34955013043

Hospital Universitario Doctor Peset, Valencia, Spain

Status

Recruiting

Address

Hospital Universitario Doctor Peset

Valencia, , 46017

Site Contact

Juan Jose Alegre

[email protected]

+34961622372