A Study To Evaluate The Efficacy And Safety Of Obinutuzumab In Patients With ISN/RPS 2003 Class III Or IV Lupus Nephritis

Study Purpose

This study will evaluate the efficacy, safety, and pharmacokinetics of obinutuzumab compared with placebo in patients with International Society of Nephrology/Renal Pathology Society (ISN/RPS) class III or IV lupus nephritis (LN) when added on to standard-of-care therapy consisting of mycophenolate mofetil (MMF) and corticosteroids.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years - 75 Years
Gender All
More Inclusion & Exclusion Criteria

Key

Inclusion Criteria:

  • - Diagnosis of ISN/RPS 2003 Class III or IV LN as evidenced by renal biopsy performed within 6 months.
Participants may co-exhibit Class V disease in addition to either Class III or Class IV disease.
  • - Urine protein to creatinine ratio greater than or equal to (>/=) 1 on a 24-hour collection.
  • - Other inclusion criteria may apply.
Key

Exclusion Criteria:

  • - Pregnancy or breastfeeding.
  • - Severe renal impairment or the need for dialysis or renal transplantation.
  • - Receipt of an excluded therapy, including any anti-CD20 therapy less than 9 months prior to screening or during screening; or cyclophosphamide, tacrolimus, ciclosporin, or voclosporin during the 2 months prior to screening or during screening.
  • - Significant or uncontrolled medical disease which, in the investigator's opinion, would preclude patient participation.
  • - Known active infection of any kind or recent major episode of infection.
  • - Intolerance or contraindication to study therapies.
- Other exclusion criteria may apply

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04221477
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Hoffmann-La Roche
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Clinical Trials
Principal Investigator Affiliation Hoffmann-La Roche
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Brazil, Canada, Colombia, France, Germany, Israel, Italy, Mexico, Peru, Poland, Russian Federation, South Africa, Spain, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Lupus Nephritis
Arms & Interventions

Arms

Experimental: Obinutuzumab

Participants will be randomized into 2 groups. Group 1 will receive obinutuzumab 1000 mg IV at baseline and Weeks 2, 24, 26, 50, and 52 plus MMF and oral prednisone. Group 2 receive obinutuzumab 1000 mg IV at baseline and Weeks 2, 24, 26, and 52 plus MMF and oral prednisone. Group 2 participants will receive a placebo infusion at their Week 50 visit. Participants with an adequate response at Week 76 will continue receiving blinded obinutuzumab infusions every 6 months starting at Week 80. Participants without an adequate response at Week 76 may be eligible for open-label obinutuzumab starting at Week 80.

Placebo Comparator: Placebo

Placebo participants will receive obinutuzumab matched placebo at baseline and Weeks 2, 24, 26, 50, and 52 plus MMF and oral prednisone. Participants with an adequate response at Week 76 will continue receiving blinded obinutuzumab infusions every 6 months starting at Week 80. Participants without an adequate response at Week 76 may be eligible for open-label obinutuzumab starting at Week 80.

Interventions

Drug: - Obinutuzumab

Obinutuzumab will be administered by IV infusion at a dose of 1000 mg at Baseline and Weeks 2, 24, 26, 50 (group 2: placebo), and 52 and subsequently from Week 80 and every 6 months thereafter, based on response.

Drug: - MMF

MMF willl be administered at a target dose of 2.0 - 2.5 g/day in divided doses through Week 80.

Drug: - Prednisone

Prednisone 0.5 mg/kg/day (maximum 60 mg/day) will be started on Day 2. Beginning on Day 16, prednisone will be tapered to 5 mg/day and continued until Week 80.

Drug: - Placebo

Placebo matching obinutuzumab will be administered by IV infusion at baseline and Weeks 0, 2, 24, 26, 50 and 52 and subsequently from Week 80 and every 6 months thereafter based on response.

Drug: - Methylprednisolone

Methylprednisolone 80 mg IV will be administered as predmedication prior to infusions.

Drug: - Acetaminophen

Acetaminophen 650-1000 mg will be administered as premedication prior to infusions.

Drug: - Diphenhydramine

Diphenhydramine 50 mg will be administered as premedication prior to infusions.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Birmingham, Alabama

Status

Not yet recruiting

Address

University of Alabama at Birmingham Medical Center

Birmingham, Alabama, 35233

Wallace Rheumatic Study Center, Beverly Hills, California

Status

Recruiting

Address

Wallace Rheumatic Study Center

Beverly Hills, California, 90211

Kaiser Permanente - Fontana, Fontana, California

Status

Not yet recruiting

Address

Kaiser Permanente - Fontana

Fontana, California, 92335

University of California San Diego, La Jolla, California

Status

Not yet recruiting

Address

University of California San Diego

La Jolla, California, 92093

San Francisco, California

Status

Recruiting

Address

Kaiser Permanente - San Francisco Medical Center

San Francisco, California, 94118

Stanford University Medical Center, Stanford, California

Status

Recruiting

Address

Stanford University Medical Center

Stanford, California, 94305-5236

Univ Colorado Health Sci Ctr, Aurora, Colorado

Status

Recruiting

Address

Univ Colorado Health Sci Ctr

Aurora, Colorado, 80045

Yale Medical Group; Rheumatology, New Haven, Connecticut

Status

Not yet recruiting

Address

Yale Medical Group; Rheumatology

New Haven, Connecticut, 06520

Univ of Florida Coll of Med, Jacksonville, Florida

Status

Withdrawn

Address

Univ of Florida Coll of Med

Jacksonville, Florida, 32209

Miami, Florida

Status

Not yet recruiting

Address

University of Miami Miller School of Medicine

Miami, Florida, 33136

Emory University, Atlanta, Georgia

Status

Not yet recruiting

Address

Emory University

Atlanta, Georgia, 30322

Northwestern University, Chicago, Illinois

Status

Not yet recruiting

Address

Northwestern University

Chicago, Illinois, 60611

Tulane University Medical Center, New Orleans, Louisiana

Status

Not yet recruiting

Address

Tulane University Medical Center

New Orleans, Louisiana, 70112

Louisiana State University, Shreveport, Louisiana

Status

Not yet recruiting

Address

Louisiana State University

Shreveport, Louisiana, 71103

Brigham and Women's Hospital, Boston, Massachusetts

Status

Not yet recruiting

Address

Brigham and Women's Hospital

Boston, Massachusetts, 02115

Nephrology Research of Michigan, Saint Clair Shores, Michigan

Status

Not yet recruiting

Address

Nephrology Research of Michigan

Saint Clair Shores, Michigan, 48081

University of Minnesota, Minneapolis, Minnesota

Status

Not yet recruiting

Address

University of Minnesota

Minneapolis, Minnesota, 55414-2959

Kansas City, Missouri

Status

Not yet recruiting

Address

Veterans Affairs Medical Center; Gastronenterology/Hepatology

Kansas City, Missouri, 64128

Washington University School of Medicine, Saint Louis, Missouri

Status

Not yet recruiting

Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Jacobi Medical Center, Bronx, New York

Status

Not yet recruiting

Address

Jacobi Medical Center

Bronx, New York, 10461

SUNY Downstate Medical Center., Brooklyn, New York

Status

Not yet recruiting

Address

SUNY Downstate Medical Center.

Brooklyn, New York, 11203

North Shore University Hospital, Manhasset, New York

Status

Active, not recruiting

Address

North Shore University Hospital

Manhasset, New York, 11030

New York, New York

Status

Recruiting

Address

NYU Langone Medical Center; Seligman Center for Advanced Therapeutics

New York, New York, 10016

Columbia Uni Medical Center; Nephrology, New York, New York

Status

Recruiting

Address

Columbia Uni Medical Center; Nephrology

New York, New York, 10032

Columbia University Medical Center, New York, New York

Status

Not yet recruiting

Address

Columbia University Medical Center

New York, New York, 10032

UNiversity of Rochester, Rochester, New York

Status

Recruiting

Address

UNiversity of Rochester

Rochester, New York, 14620

Columbus, Ohio

Status

Recruiting

Address

The Ohio State University Wexner Medical Center

Columbus, Ohio, 43212

STAT Research Inc, Dayton, Ohio

Status

Recruiting

Address

STAT Research Inc

Dayton, Ohio, 45417

Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma

Status

Recruiting

Address

Oklahoma Medical Research Foundation

Oklahoma City, Oklahoma, 73104

Perelman Ctr for Advanced Med, Philadelphia, Pennsylvania

Status

Not yet recruiting

Address

Perelman Ctr for Advanced Med

Philadelphia, Pennsylvania, 19104

Piedmont Arthritis Clinic, Greenville, South Carolina

Status

Recruiting

Address

Piedmont Arthritis Clinic

Greenville, South Carolina, 29601

Georgia Nephrology, Chattanooga, Tennessee

Status

Active, not recruiting

Address

Georgia Nephrology

Chattanooga, Tennessee, 37404

Southeast Renal Research Institute, Chattanooga, Tennessee

Status

Withdrawn

Address

Southeast Renal Research Institute

Chattanooga, Tennessee, 37404

University of Texas Southwestern, Dallas, Texas

Status

Recruiting

Address

University of Texas Southwestern

Dallas, Texas, 75390-8897

Southwest Rheumatology, Mesquite, Texas

Status

Recruiting

Address

Southwest Rheumatology

Mesquite, Texas, 75150

Madison, Wisconsin

Status

Not yet recruiting

Address

University of Wisconsin School of Medicine and Public Health

Madison, Wisconsin, 53792

International Sites

Organizacion Medica de Investigacion, Buenos Aires, Argentina

Status

Recruiting

Address

Organizacion Medica de Investigacion

Buenos Aires, , C1015ABO

Fundación Favaloro, Capital Federal, Argentina

Status

Not yet recruiting

Address

Fundación Favaloro

Capital Federal, , C1095

DOM Centro de Reumatología, Ciudad Autónoma de Buenos Aires, Argentina

Status

Recruiting

Address

DOM Centro de Reumatología

Ciudad Autónoma de Buenos Aires, , C1111AAJ

Ciudad Autónoma de Buenos Aires, Argentina

Status

Not yet recruiting

Address

Hospital Italiano de Buenos Aires; Rheumatology department

Ciudad Autónoma de Buenos Aires, , C1199ABD

Sanatorio Allende, Cordoba, Argentina

Status

Recruiting

Address

Sanatorio Allende

Cordoba, , X5000JHQ

Sanatorio Parque S.A., Rosario, Santa FE, Argentina

Status

Not yet recruiting

Address

Sanatorio Parque S.A.

Rosario, Santa FE, , 2013

San Juan, Argentina

Status

Not yet recruiting

Address

CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica

San Juan, , 5400

Salvador, BA, Brazil

Status

Recruiting

Address

Ser Servicos Especializados Em Reumatologia

Salvador, BA, 40150-150

Instituto Pro-Renal, Curitiba, PR, Brazil

Status

Recruiting

Address

Instituto Pro-Renal

Curitiba, PR, 80440-020

Edumed - Educação e Saúde SA, Curitiba, PR, Brazil

Status

Recruiting

Address

Edumed - Educação e Saúde SA

Curitiba, PR, 80440-080

Hospital das Clinicas - UFRGS, Porto Alegre, RS, Brazil

Status

Recruiting

Address

Hospital das Clinicas - UFRGS

Porto Alegre, RS, 90035-903

Hospital das Clinicas - UNICAMP, Campinas, SP, Brazil

Status

Not yet recruiting

Address

Hospital das Clinicas - UNICAMP

Campinas, SP, 13083-888

Ribeirao Preto, SP, Brazil

Status

Recruiting

Address

Hospital das Clinicas - FMUSP Ribeirao Preto; Reumatologia

Ribeirao Preto, SP, 14051-140

Santo Andre, SP, Brazil

Status

Recruiting

Address

Centro Multidisciplinar de Estudos Clínicos - CEMEC*X*

Santo Andre, SP, 09190-510

Hospital das Clinicas - FMUSP, Sao Paulo, SP, Brazil

Status

Not yet recruiting

Address

Hospital das Clinicas - FMUSP

Sao Paulo, SP, 05403-000

Nexus Clinical Research Inc., St. John's, Newfoundland and Labrador, Canada

Status

Withdrawn

Address

Nexus Clinical Research Inc.

St. John's, Newfoundland and Labrador, A1A 5E8

Toronto, Ontario, Canada

Status

Not yet recruiting

Address

Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex

Toronto, Ontario, M5T 3L9

Clinica De La Costa, Barranquilla, Colombia

Status

Recruiting

Address

Clinica De La Costa

Barranquilla, , 080020

Hospital Universitario San Ignacio, Bogota, Colombia

Status

Recruiting

Address

Hospital Universitario San Ignacio

Bogota, , 000472

Bogotá, Colombia

Status

Withdrawn

Address

Sociedad de Cirugia de Bogota Hospital San Jose

Bogotá, , 111411

FOSCAL, Floridablanca, Colombia

Status

Withdrawn

Address

FOSCAL

Floridablanca, ,

Hospital Pablo Tobon Uribe, Medellin, Colombia

Status

Recruiting

Address

Hospital Pablo Tobon Uribe

Medellin, , 050034

Creteil, France

Status

Recruiting

Address

HOPITAL HENRI MONDOR; SERVICE DE Nephrologie

Creteil, , 94010

FORT DE France, France

Status

Not yet recruiting

Address

CHU de Martinique- Hôpital P. Zobda-Quitman; Service de Rhumatlogie- Médecine interne 5D

FORT DE France, , 97261

Hopital Claude Huriez; Internal Medicine, Lille, France

Status

Recruiting

Address

Hopital Claude Huriez; Internal Medicine

Lille, , 59037

Hopital Europeen, Marseille, France

Status

Recruiting

Address

Hopital Europeen

Marseille, , 13003

Paris, France

Status

Recruiting

Address

Groupe Hospitalier Pitie-Salpetriere; Service de Medecine Interne Ii

Paris, , 75651

Paris, France

Status

Active, not recruiting

Address

Hopital Bichat Claude Bernard; Nephrologie

Paris, , 75877

Hopital Sud ; Nephrologie Hemodialyse, Salouel, France

Status

Recruiting

Address

Hopital Sud ; Nephrologie Hemodialyse

Salouel, , 80480

Strasbourg, France

Status

Not yet recruiting

Address

Hopital Universitaire; Nephrologie Clinique Medicale B

Strasbourg, , 67091

Toulouse, France

Status

Recruiting

Address

Hopital Rangueil; Service de Nephrologie & D'Immunologie Clinique

Toulouse, , 31059

Berlin, Germany

Status

Recruiting

Address

Charité Campus Mitte, Med.Klinik, Rheumatologie und Klinische Immunologie

Berlin, , 10117

Dresden, Germany

Status

Recruiting

Address

Städtisches Klinik Dresden-Friedrichstadt; I. Medizinische Klinik

Dresden, , 01067

Dresden, Germany

Status

Recruiting

Address

Universitätsklinikum "Carl Gustav Carus"; Medizinische Klinik III

Dresden, , 01307

Universitätsklinikum Freiburg, Freiburg, Germany

Status

Not yet recruiting

Address

Universitätsklinikum Freiburg

Freiburg, , 79106

Kiel, Germany

Status

Recruiting

Address

Universitatsklinikum Schleswig Holstein; Klinik fur Allgemeine Innere Medizin

Kiel, , 24105

Mainz, Germany

Status

Recruiting

Address

Universitaetsmedizin Johannes Gutenberg; Rheumatologie

Mainz, , 55131

Tübingen, Germany

Status

Recruiting

Address

Universitätskrankenhaus Tübingen; Rheumatol. / Haematol. / Internist. Onkologie

Tübingen, , 72076

Rambam Health Care Campus, Haifa, Israel

Status

Recruiting

Address

Rambam Health Care Campus

Haifa, , 3109600

Meir Medical Center, Kfar- Saba, Israel

Status

Recruiting

Address

Meir Medical Center

Kfar- Saba, , 4428164

Rabin MC- Belinson campus, Petach Tikva, Israel

Status

Recruiting

Address

Rabin MC- Belinson campus

Petach Tikva, , 4941492

Chaim Sheba Medical Center; Rheumatology, Ramat-Gan, Israel

Status

Recruiting

Address

Chaim Sheba Medical Center; Rheumatology

Ramat-Gan, , 5262100

Sourasky Medical Centre, Tel-Aviv, Israel

Status

Recruiting

Address

Sourasky Medical Centre

Tel-Aviv, , 6423906

Ospedale Policlinico San Martino, Genova, Liguria, Italy

Status

Recruiting

Address

Ospedale Policlinico San Martino

Genova, Liguria, 16132

Brescia, Lombardia, Italy

Status

Recruiting

Address

A.O. Spedali Civili Di Brescia-P.O. Spedali Civili; Nefrologia

Brescia, Lombardia, 25123

Brescia, Lombardia, Italy

Status

Recruiting

Address

Asst Degli Spedali Civili Di Brescia; Reumatologia Ed Immunologia Clinica

Brescia, Lombardia, 25125

Monza, Lombardia, Italy

Status

Recruiting

Address

ASST Monza - Ospedale San Gerardo; Clinica Nefrologica

Monza, Lombardia, 20900

Torino, Piemonte, Italy

Status

Not yet recruiting

Address

Ospedale San Giovanni Bosco; Unita Operativa Nefrologia Dialisi

Torino, Piemonte, 10154

Bari, Puglia, Italy

Status

Recruiting

Address

Policlinico di Bari; Divisione di Nefrologia, Dialisi e Trapianto

Bari, Puglia, 70124

Palermo, Sicilia, Italy

Status

Recruiting

Address

Ospedale ARNAS - P.O."Civico e Benfratelli; UOC Nefrologia e Dialisi

Palermo, Sicilia, 90127

Firenze, Toscana, Italy

Status

Recruiting

Address

Azienda Ospedaliera Universitaria Careggi

Firenze, Toscana, 50141

Padova, Veneto, Italy

Status

Not yet recruiting

Address

Azienda Ospedaliera di Padova; Dipartimento di Medicina - UOC di Reumatologia

Padova, Veneto, 35128

Mexico City, Mexico

Status

Not yet recruiting

Address

Instituto Nacional de Ciencias Médicas Y de La Nutricion Zubirán

Mexico City, , Tlalpan 14000

Hospital General De Mexico; Rheumatology, Mexico, D.F., Mexico

Status

Not yet recruiting

Address

Hospital General De Mexico; Rheumatology

Mexico, D.F., , 06726

Mexico, DF, Mexico

Status

Not yet recruiting

Address

Centro de Investigación y Tratamiento Reumatológico S.C.

Mexico, DF, , 11850

Monterrey, Mexico

Status

Not yet recruiting

Address

Hospital Universitario; Dr. Jose Eleuterio Gonzalez

Monterrey, , 64460

Hogar Clínica San Juan de Dios, Arequipa, Peru

Status

Not yet recruiting

Address

Hogar Clínica San Juan de Dios

Arequipa, , 04000

Lima, Peru

Status

Recruiting

Address

Hospital Nacional Edgardo Rebagliati Martins; Servicio de Reumatología

Lima, , 11

Lima, Peru

Status

Recruiting

Address

Servicio de Inmuno Reumatologia; Hospital Nacional Arzobispo Loayza

Lima, , 15082

Lima, Peru

Status

Recruiting

Address

Clínica San Juan Bautista CSJB; UNIDAD DE INVESTIGACION EN REUMATOLOGIA E INMUNOLOGIA CSJB

Lima, , 15431

Lima, Peru

Status

Recruiting

Address

Instituto del Cerebro y la Columna Vertebral SAC

Lima, , Lima 18

Clinica Anglo Americana; Rheumatology, Lima, Peru

Status

Recruiting

Address

Clinica Anglo Americana; Rheumatology

Lima, ,

Instituto de Ginecología y Reproducción, Lima, Peru

Status

Recruiting

Address

Instituto de Ginecología y Reproducción

Lima, ,

San Martin de Porres, Peru

Status

Recruiting

Address

Hospital Nacional Cayetano Heredia; Rheumatology

San Martin de Porres, , 15102

Katowice, Poland

Status

Not yet recruiting

Address

SPSK Slaskiego UM w Katowicach; Katedra i Klinika Nefrologii, Endokryn.I Chorob Przemiany Materii

Katowice, , 40-027

Katowice, Poland

Status

Not yet recruiting

Address

SPSK Nr 7 SUM w Katowicach Gornoslaskie CM im. prof. Leszka Gieca

Katowice, , 40-635

Krakow, Poland

Status

Not yet recruiting

Address

Szpital Specjalistyczny im Jozefa Dietla; Centrum Reumatologii, Immunologii i Rehabilitacji, I Oddzi

Krakow, , 31-121

Lodz, Poland

Status

Withdrawn

Address

Uniwersytecki Szpital Kliniczny Nr 2 Im. Wam; Centralny Szpital Weteranow

Lodz, , 90-549

SPZOZ Centralny Szpital Klin; UM w Lodzi, Lodz, Poland

Status

Recruiting

Address

SPZOZ Centralny Szpital Klin; UM w Lodzi

Lodz, , 92-213

Lublin, Poland

Status

Not yet recruiting

Address

Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie

Lublin, , 20-954

Nowa Sól, Poland

Status

Not yet recruiting

Address

Twoja Przychodnia Centrum Medyczne Nowa Sol

Nowa Sól, , 67-100

Medyczne Centrum Hetmanska; Rheumatology, Poznan, Poland

Status

Not yet recruiting

Address

Medyczne Centrum Hetmanska; Rheumatology

Poznan, , 60-218

Poznan, Poland

Status

Not yet recruiting

Address

Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi UM; Katedra i Klinika Reumatologii

Poznan, , 61-545

Szczecin, Poland

Status

Recruiting

Address

SPSK nr 2 Pomorskiej AM w Szczecinie; Klinika Nefrologii, Transplantologii i Chorob Wewnetrznych

Szczecin, , 70-111

Szczecin, Poland

Status

Not yet recruiting

Address

SP Szpital Kliniczny nr 1 Pomorskiej Akademii Medycznej im. prof. Tadeusza Sokolowskiego

Szczecin, , 71-252

Szpital Kliniczny Dzieciatka Jezus, Warszawa, Poland

Status

Not yet recruiting

Address

Szpital Kliniczny Dzieciatka Jezus

Warszawa, , 02-005

Rheuma Medicus Zaklad Opieki Zdrowotnej, Warszawa, Poland

Status

Not yet recruiting

Address

Rheuma Medicus Zaklad Opieki Zdrowotnej

Warszawa, , 02-118

Warszawa, Poland

Status

Not yet recruiting

Address

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. Prof. Eleonory Reicher

Warszawa, , 02-637

Wroclaw, Poland

Status

Recruiting

Address

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu

Wroclaw, , 50-556

Sankt-peterburg, Leningrad, Russian Federation

Status

Recruiting

Address

SBEI HPE "The First St.Petersburg State Medical University n.a. acad. I.P.Pavlova"of MoH of RF

Sankt-peterburg, Leningrad, 197022

Moscow, Moskovskaja Oblast, Russian Federation

Status

Recruiting

Address

Federal State Budgetary Scientific Institution Research Institute of Rheumatology V.A. Nasonova

Moscow, Moskovskaja Oblast, 115522

Kazan, Tatarstan, Russian Federation

Status

Recruiting

Address

"Kazan (Privolzhsky) Federal University"; Academic Hospital

Kazan, Tatarstan, 420043

Kemerovo, Russian Federation

Status

Not yet recruiting

Address

SIH Kemerovo Regional Clinical Hospital; Neurology department

Kemerovo, , 650061

Moscow, Russian Federation

Status

Not yet recruiting

Address

SBIH of Moscow "City Clinical Hospital #20 of Moscow Healthcare Department"

Moscow, , 129327

Novosibirsk, Russian Federation

Status

Not yet recruiting

Address

Limited Liability Company "Centre of Medical Common Practice"

Novosibirsk, , 630091

Petrozavodsk, Russian Federation

Status

Recruiting

Address

Republican Hospital Named After V.A. Baranov

Petrozavodsk, , 185019

Saint-Petersburg, Russian Federation

Status

Recruiting

Address

Federal Centre of Heart, Blood and Endocrinology n.a. V.A.Almazov; Rheumatology Department

Saint-Petersburg, , 197341

Regional Clinical Hospital, Saratov, Russian Federation

Status

Not yet recruiting

Address

Regional Clinical Hospital

Saratov, , 410053

Cape Town, South Africa

Status

Recruiting

Address

Winelands Medical Research; Medical Research

Cape Town, , 7600

Cape Town, South Africa

Status

Not yet recruiting

Address

Groote Schuur Hospital and University of Cape Town; E13 Renal Unit & J46 Dept of Medicine

Cape Town, , 7925

Precise Clinical Solutions (Pty) Ltd, Chatsworth, South Africa

Status

Not yet recruiting

Address

Precise Clinical Solutions (Pty) Ltd

Chatsworth, , 4092

Chris Hani Baragwanath Hospital, Johannesburg, South Africa

Status

Recruiting

Address

Chris Hani Baragwanath Hospital

Johannesburg, , 2013

Panorama, South Africa

Status

Recruiting

Address

Panaroma Medical Center; Clinical Trials Department

Panorama, , 7500

Vitoria, Alava, Spain

Status

Recruiting

Address

Hospital Universitario Araba; Servicio de Reumatologia

Vitoria, Alava, 01009

Hospitalet de Llobregat, Barcelona, Spain

Status

Recruiting

Address

Hospital Universitari de Bellvitge; Servicio de Nefrologia

Hospitalet de Llobregat, Barcelona, 08907

La Coruna, LA Coruña, Spain

Status

Not yet recruiting

Address

Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Reumatologia

La Coruna, LA Coruña, 15006

Santiago de Compostela, LA Coruña, Spain

Status

Recruiting

Address

Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Medicina Interna

Santiago de Compostela, LA Coruña, 15706

Las Palmas de Gran Canaria, LAS Palmas, Spain

Status

Not yet recruiting

Address

Hospital de Gran Canaria Dr. Negrin; Servicio de Reumatologia

Las Palmas de Gran Canaria, LAS Palmas, 35010

Bilbao, Vizcaya, Spain

Status

Recruiting

Address

Hospital de Basurto; Servicio de Reumatologia

Bilbao, Vizcaya, 48013

Barcelona, Spain

Status

Active, not recruiting

Address

Hospital Universitario Vall d'Hebron; Servicio de Medicina Interna

Barcelona, , 08035

Barcelona, Spain

Status

Recruiting

Address

Hospital Clinic i Provincial; Servicio de Nefrologia

Barcelona, , 08036

Cordoba, Spain

Status

Recruiting

Address

Hospital Universitario Reina Sofia; Servicio de Nefrologia

Cordoba, , 14004

Madrid, Spain

Status

Recruiting

Address

Hospital General Universitario Gregorio Marañon; Servicio de Reumatología

Madrid, , 28007

Madrid, Spain

Status

Not yet recruiting

Address

Hospital Ramon y Cajal ; Servicio de Reumatologia

Madrid, , 28034

Madrid, Spain

Status

Recruiting

Address

Hospital Universitario 12 de Octubre; Servicio de Reumatologia

Madrid, , 28041

Cambridge, United Kingdom

Status

Recruiting

Address

Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital

Cambridge, , CB2 0QQ

Leeds, United Kingdom

Status

Not yet recruiting

Address

CHAPEL ALLERTON HOSPITAL; Unit of Musculoskeletal Disease

Leeds, , LS7 4SA

London, United Kingdom

Status

Not yet recruiting

Address

Royal Free Hospital; Centre for Nephrology

London, , NW3 2PF

Guy's Hospital; Louise Coote Lupus Unit, London, United Kingdom

Status

Not yet recruiting

Address

Guy's Hospital; Louise Coote Lupus Unit

London, , SE1 9RT

St George's Hospital, London, United Kingdom

Status

Not yet recruiting

Address

St George's Hospital

London, , SW17 ORE

Hammersmith Hospital; Nephrology Dept, London, United Kingdom

Status

Not yet recruiting

Address

Hammersmith Hospital; Nephrology Dept

London, , W12 OHS