A Study to Evaluate Efficacy and Safety of Upadacitinib in Adult Participants With Axial Spondyloarthritis

Study Purpose

This protocol includes 2 standalone studies with randomization, data collection, analysis and reporting conducted independently. The main objectives of this protocol are:

  • - To evaluate the efficacy of upadacitinib compared with placebo on reduction of signs and symptoms in adult participants with active axial spondyloarthritis (axSpA) including biologic disease-modifying antirheumatic drug inadequate responders (bDMARD-IR) ankylosing spondylitis (AS) (Study 1) and non-radiographic axial spondyloarthritis (nr-axSpA) (Study 2).
  • - To assess the safety and tolerability of upadacitinib in adult participants with active axSpA including bDMARD-IR AS (Study 1) and with nr-axSpA (Study 2).

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Study 1: Participant has the clinical diagnosis of ankylosing spondylitis (AS) who meet the modified New York Criteria for AS (Study 1); OR.
  • - Study 2: Participant has the clinical diagnosis of nr-axSpA fulfilling the 2009 ASAS classification criteria for axSpA but not meeting the radiologic criterion of the modified New York criteria for AS and have objective signs of active inflammation on magnetic resonance imaging (MRI) or based on high sensitivity C-reactive protein (CRP).
  • - Study 1 and Study 2: Participant must have a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score ≥ 4 and a Patient's Assessment of Total Back Pain score ≥ 4 based on a 0 - 10 numerical rating scale at the Screening and Baseline Visits.
  • - Study 1: Participants must have had an inadequate response to biologic disease-modifying antirheumatic drug (bDMARD) therapy.
  • - Study 2: Participant with prior treatment with bDMARD-therapy is allowed.

Exclusion Criteria:

  • - Participant must not have been exposed to Janus Kinase (JAK) inhibitor.
  • - Prior bDMARD therapy has to be washed out.
  • - Participant must not have a history of an allergic reaction or significant sensitivity to constituents of the study drug.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04169373
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

AbbVie
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

AbbVie Inc.
Principal Investigator Affiliation AbbVie
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Australia, Belgium, Brazil, Bulgaria, Canada, China, Czechia, France, Germany, Hungary, Israel, Italy, Japan, Korea, Republic of, Mexico, New Zealand, Poland, Russian Federation, Slovakia, Spain, Taiwan, Turkey, Ukraine, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Spondyloarthritis
Study Website: View Trial Website
Arms & Interventions

Arms

Experimental: Study 1: Upadacitinib

Participants will be administered upadacitinib for 104 weeks

Experimental: Study 1: Placebo

Participants will be administered placebo for 14 weeks followed by upadacitinib for 90 weeks

Experimental: Study 2: Upadacitinib

Participants will be administered upadacitinib for 104 weeks

Experimental: Study 2: Placebo

Participants will be administered placebo for 52 weeks followed by upadacitinib for 52 weeks

Interventions

Drug: - Upadacitinib

Upadacitinib is administered as oral tablet

Drug: - Placebo

Placebo for upadacitinib is administered as oral tablet

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Flagstaff, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatology Associates, P.C. /ID# 215282

Flagstaff, Arizona, 86001-6269

Phoenix, Arizona

Status

Recruiting

Address

AZ Arthritis and Rheumotology Research, PLLC /ID# 215113

Phoenix, Arizona, 85032-9306

Tucson, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatology Research, PLLC /ID# 214731

Tucson, Arizona, 85704

Huntington Beach, California

Status

Recruiting

Address

Care Access Research, Huntington Beach /ID# 216281

Huntington Beach, California, 92648-5994

Inland Rheum & Osteo Med Grp /ID# 215807, Upland, California

Status

Recruiting

Address

Inland Rheum & Osteo Med Grp /ID# 215807

Upland, California, 91786

Denver Arthritis Clinic /ID# 215346, Denver, Colorado

Status

Recruiting

Address

Denver Arthritis Clinic /ID# 215346

Denver, Colorado, 80230

Tekton Research /ID# 215054, Fort Collins, Colorado

Status

Recruiting

Address

Tekton Research /ID# 215054

Fort Collins, Colorado, 80528

Aventura, Florida

Status

Recruiting

Address

Arthritis & Rheumatic Disease Specialties /ID# 215306

Aventura, Florida, 33180

Hialeah, Florida

Status

Recruiting

Address

Sweet Hope Research Specialty Inc /ID# 215931

Hialeah, Florida, 33016-1897

Palmetto Bay, Florida

Status

Recruiting

Address

Innovation Medical Research Center /ID# 216068

Palmetto Bay, Florida, 33157-1737

Conquest Research /ID# 215804, Winter Park, Florida

Status

Recruiting

Address

Conquest Research /ID# 215804

Winter Park, Florida, 32789

Great Lakes Clinical Trials /ID# 215790, Chicago, Illinois

Status

Recruiting

Address

Great Lakes Clinical Trials /ID# 215790

Chicago, Illinois, 60640

Schaumburg, Illinois

Status

Recruiting

Address

Greater Chicago Specialty Physicians /ID# 216213

Schaumburg, Illinois, 60195-3106

Skokie, Illinois

Status

Recruiting

Address

Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 215055

Skokie, Illinois, 60076

Cumberland, Maryland

Status

Recruiting

Address

Klein & Associates, M.D., P.A. /ID# 214767

Cumberland, Maryland, 21502

Tufts Medical Center /ID# 215925, Boston, Massachusetts

Status

Recruiting

Address

Tufts Medical Center /ID# 215925

Boston, Massachusetts, 02111

Worcester, Massachusetts

Status

Recruiting

Address

Clinical Pharmacology Study Gr /ID# 215293

Worcester, Massachusetts, 01605

Detroit, Michigan

Status

Recruiting

Address

Wayne State University Health Center /ID# 215930

Detroit, Michigan, 48201-2153

Advanced Rheumatology, PC /ID# 214973, Lansing, Michigan

Status

Recruiting

Address

Advanced Rheumatology, PC /ID# 214973

Lansing, Michigan, 48910

St. Paul Rheumatology, P.A. /ID# 215537, Eagan, Minnesota

Status

Recruiting

Address

St. Paul Rheumatology, P.A. /ID# 215537

Eagan, Minnesota, 55121

Saint Louis, Missouri

Status

Completed

Address

CenterPointe Institute of Research /ID# 215793

Saint Louis, Missouri, 63128-3841

Clinvest Research LLC /ID# 215785, Springfield, Missouri

Status

Recruiting

Address

Clinvest Research LLC /ID# 215785

Springfield, Missouri, 65810-2607

New York, New York

Status

Recruiting

Address

NYU Langone Orthopedic Center /ID# 215594

New York, New York, 10016-2772

St. Lawrence Health System /ID# 215844, Potsdam, New York

Status

Recruiting

Address

St. Lawrence Health System /ID# 215844

Potsdam, New York, 13676

Cape Fear Arthritis Care /ID# 215927, Leland, North Carolina

Status

Recruiting

Address

Cape Fear Arthritis Care /ID# 215927

Leland, North Carolina, 28451

Marietta Memorial Hospital /ID# 215929, Marietta, Ohio

Status

Recruiting

Address

Marietta Memorial Hospital /ID# 215929

Marietta, Ohio, 45750-1635

STAT Research, Inc. /ID# 215264, Springboro, Ohio

Status

Recruiting

Address

STAT Research, Inc. /ID# 215264

Springboro, Ohio, 45066

Health Research of Oklahoma /ID# 215117, Oklahoma City, Oklahoma

Status

Recruiting

Address

Health Research of Oklahoma /ID# 215117

Oklahoma City, Oklahoma, 73103-2400

Portland, Oregon

Status

Not yet recruiting

Address

Oregon Health and Science University /ID# 216446

Portland, Oregon, 97239

Altoona Ctr Clinical Res /ID# 214770, Duncansville, Pennsylvania

Status

Recruiting

Address

Altoona Ctr Clinical Res /ID# 214770

Duncansville, Pennsylvania, 16635

Tekton Research, Inc. /ID# 214923, Austin, Texas

Status

Recruiting

Address

Tekton Research, Inc. /ID# 214923

Austin, Texas, 78745

Trinity Universal Res Assoc /ID# 214948, Carrollton, Texas

Status

Recruiting

Address

Trinity Universal Res Assoc /ID# 214948

Carrollton, Texas, 75007

College Station, Texas

Status

Completed

Address

Arth and Osteo Clin Brazo Valley /ID# 215805

College Station, Texas, 77845

JPS Health Network /ID# 215962, Fort Worth, Texas

Status

Recruiting

Address

JPS Health Network /ID# 215962

Fort Worth, Texas, 76104-4917

Houston, Texas

Status

Recruiting

Address

Biopharma Informatic Research /ID# 215907

Houston, Texas, 77024-2420

Memorial Rheumatology /ID# 216311, Houston, Texas

Status

Recruiting

Address

Memorial Rheumatology /ID# 216311

Houston, Texas, 77024-2420

Biopharma Informatic, LLC /ID# 215885, Houston, Texas

Status

Recruiting

Address

Biopharma Informatic, LLC /ID# 215885

Houston, Texas, 77043

West Texas Clinical Research /ID# 215928, Lubbock, Texas

Status

Recruiting

Address

West Texas Clinical Research /ID# 215928

Lubbock, Texas, 79410-1198

Plano, Texas

Status

Recruiting

Address

Trinity Universal Research Associates, Inc /ID# 215189

Plano, Texas, 75024-5283

Beckley, West Virginia

Status

Recruiting

Address

Rheumatology and Pulmonary Clinic /ID# 214946

Beckley, West Virginia, 25801

West Virginia Research Inst /ID# 214921, South Charleston, West Virginia

Status

Recruiting

Address

West Virginia Research Inst /ID# 214921

South Charleston, West Virginia, 25309

International Sites

Instituto CAICI SRL /ID# 215242, Rosario, Santa Fe, Argentina

Status

Recruiting

Address

Instituto CAICI SRL /ID# 215242

Rosario, Santa Fe, 2000

Centro Medico Privado/Reuma /ID# 214559, San Miguel de Tucuman, Tucuman, Argentina

Status

Recruiting

Address

Centro Medico Privado/Reuma /ID# 214559

San Miguel de Tucuman, Tucuman, 4000

Buenos Aires, Argentina

Status

Recruiting

Address

Organizacion Medica de Investigacion (OMI) /ID# 214557

Buenos Aires, , 1015

Hospital Cordoba /ID# 215846, Cordoba, Argentina

Status

Recruiting

Address

Hospital Cordoba /ID# 215846

Cordoba, , 5000

Cordoba, Argentina

Status

Recruiting

Address

Inst. Rheumatologic Strusberg /ID# 215239

Cordoba, , 5000

Cimer /Id# 215240, San Miguel de Tucuman, Argentina

Status

Recruiting

Address

Cimer /Id# 215240

San Miguel de Tucuman, , 4000

Santa Fe, Argentina

Status

Recruiting

Address

Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 214556

Santa Fe, , 2000

Emeritus Research Sydney /ID# 215507, Botany, New South Wales, Australia

Status

Recruiting

Address

Emeritus Research Sydney /ID# 215507

Botany, New South Wales, 2019

BJC Health /ID# 215510, Paramatta, New South Wales, Australia

Status

Recruiting

Address

BJC Health /ID# 215510

Paramatta, New South Wales, 2150

Emeritus Research /ID# 215506, Camberwell, Victoria, Australia

Status

Recruiting

Address

Emeritus Research /ID# 215506

Camberwell, Victoria, 3124

Monash Health /ID# 215509, Clayton, Victoria, Australia

Status

Recruiting

Address

Monash Health /ID# 215509

Clayton, Victoria, 3168

Barwon Rheumatology /ID# 215508, Geelong, Victoria, Australia

Status

Recruiting

Address

Barwon Rheumatology /ID# 215508

Geelong, Victoria, 3220

UZ Gent /ID# 215004, Gent, Oost-Vlaanderen, Belgium

Status

Recruiting

Address

UZ Gent /ID# 215004

Gent, Oost-Vlaanderen, 9000

ReumaClinic Genk /ID# 215005, Genk, Belgium

Status

Recruiting

Address

ReumaClinic Genk /ID# 215005

Genk, , 3600

UZ Leuven /ID# 215006, Leuven, Belgium

Status

Recruiting

Address

UZ Leuven /ID# 215006

Leuven, , 3000

Juiz de Fora, Minas Gerais, Brazil

Status

Recruiting

Address

CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 215277

Juiz de Fora, Minas Gerais, 36010-570

Curitiba, Parana, Brazil

Status

Recruiting

Address

EDUMED Educacao em Saude S/S L /ID# 215111

Curitiba, Parana, 80440-080

LMK Sevicos Medicos S/S /ID# 215112, Porto Alegre, Rio Grande Do Sul, Brazil

Status

Recruiting

Address

LMK Sevicos Medicos S/S /ID# 215112

Porto Alegre, Rio Grande Do Sul, 90480-000

Sao Jose Do Rio Preto, Sao Paulo, Brazil

Status

Recruiting

Address

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 215176

Sao Jose Do Rio Preto, Sao Paulo, 15090-000

Sao Paulo, Brazil

Status

Recruiting

Address

CPCLIN - Centro de Pesquisas Clínicas /ID# 215175

Sao Paulo, , 01244-030

MHAT Kaspela /ID# 214803, Plovdiv, Bulgaria

Status

Active, not recruiting

Address

MHAT Kaspela /ID# 214803

Plovdiv, , 4001

MHAT-Plovdiv AD /ID# 214815, Plovdiv, Bulgaria

Status

Active, not recruiting

Address

MHAT-Plovdiv AD /ID# 214815

Plovdiv, , 4003

Unimed Medical Center /ID# 214816, Plovdiv, Bulgaria

Status

Active, not recruiting

Address

Unimed Medical Center /ID# 214816

Plovdiv, , 4023

Ruse, Bulgaria

Status

Active, not recruiting

Address

Medical Center - Teodora EOOD /ID# 214813

Ruse, , 7012

Excelsior Medical Center /ID# 214805, Sofia, Bulgaria

Status

Active, not recruiting

Address

Excelsior Medical Center /ID# 214805

Sofia, , 1407

Sofia, Bulgaria

Status

Active, not recruiting

Address

Diag Consult Ctr 17 Sofia EOOD /ID# 214808

Sofia, , 1505

UMHAT Sv. Ivan Rilski /ID# 214804, Sofia, Bulgaria

Status

Active, not recruiting

Address

UMHAT Sv. Ivan Rilski /ID# 214804

Sofia, , 1612

UMHAT Sv. Ivan Rilski /ID# 214806, Sofia, Bulgaria

Status

Active, not recruiting

Address

UMHAT Sv. Ivan Rilski /ID# 214806

Sofia, , 1612

Edmonton, Alberta, Canada

Status

Not yet recruiting

Address

University of Alberta - Division of Rheumatology /ID# 216360

Edmonton, Alberta, T6G 2B7

Victoria, British Columbia, Canada

Status

Recruiting

Address

Percuro Clinical Research, Ltd /ID# 215302

Victoria, British Columbia, V8V 3M9

Toronto Western Hospital /ID# 215041, Toronto, Ontario, Canada

Status

Recruiting

Address

Toronto Western Hospital /ID# 215041

Toronto, Ontario, M5T 2S8

Montréal, Quebec, Canada

Status

Recruiting

Address

Applied Medical Informatics Research Inc. (AMIR) /ID# 215303

Montréal, Quebec, H4A 3T2

Trois-rivières, Quebec, Canada

Status

Recruiting

Address

Ctr. de Recherche Musculo-Sque /ID# 215096

Trois-rivières, Quebec, G8Z 1Y2

Centre de recherche du CHUQ /ID# 215038, Quebec, Canada

Status

Recruiting

Address

Centre de recherche du CHUQ /ID# 215038

Quebec, , G1R 3S2

Bengbu, Anhui, China

Status

Recruiting

Address

1st Aff Hosp of Bengbu Medical College /ID# 216609

Bengbu, Anhui, 233004

Anhui Provincial Hospital /ID# 216631, Hefei, Anhui, China

Status

Recruiting

Address

Anhui Provincial Hospital /ID# 216631

Hefei, Anhui, 230001

Guangzhou, Guangdong, China

Status

Recruiting

Address

Guangdong Provincial People's Hospital /ID# 216645

Guangzhou, Guangdong, 510080

Shantou, Guangdong, China

Status

Recruiting

Address

The First Affiliated Hospital of Shantou University Medical College /ID# 217883

Shantou, Guangdong, 515041

Shenzhen People's Hospital /ID# 225438, Shenzhen, Guangdong, China

Status

Recruiting

Address

Shenzhen People's Hospital /ID# 225438

Shenzhen, Guangdong, 518020

Zhuzhou Central Hospital /ID# 216644, Zhuzhou, Hunan, China

Status

Recruiting

Address

Zhuzhou Central Hospital /ID# 216644

Zhuzhou, Hunan, 412007

Baotou, Inner Mongolia, China

Status

Recruiting

Address

The First Affiliated Hospital of Baotou Medical College, Inner Monggolia Univers /ID# 216612

Baotou, Inner Mongolia, 014016

Shanghai, Shanghai, China

Status

Recruiting

Address

Huashan Hospital, Fudan University /ID# 216646

Shanghai, Shanghai, 200040

Beijing, China

Status

Recruiting

Address

Peking Union Med College Hosp /ID# 216545

Beijing, , 100730

Kunming, China

Status

Recruiting

Address

First Affiliated Hospital of Kunming Medical University /ID# 217945

Kunming, , 650032

Soochow, China

Status

Recruiting

Address

The First Affiliated Hospital of Soochow University /ID# 216607

Soochow, , 215006

Urumqi, China

Status

Not yet recruiting

Address

People's Hospital of Xinjiang /ID# 216630

Urumqi, , 830001

Revmatologicky ustav Praha /ID# 215154, Prague 2, Praha 2, Czechia

Status

Recruiting

Address

Revmatologicky ustav Praha /ID# 215154

Prague 2, Praha 2, 128 00

Revmatologicka ambulance /ID# 215652, Prague 4, Praha 4, Czechia

Status

Recruiting

Address

Revmatologicka ambulance /ID# 215652

Prague 4, Praha 4, 140 00

Thomayerova nemocnice /ID# 215118, Prague, Praha 4, Czechia

Status

Recruiting

Address

Thomayerova nemocnice /ID# 215118

Prague, Praha 4, 140 59

Fakultni Nemocnice v Motole /ID# 215160, Prague 5, Praha 5, Czechia

Status

Recruiting

Address

Fakultni Nemocnice v Motole /ID# 215160

Prague 5, Praha 5, 150 06

PV MEDICAL Services s.r.o. /ID# 215119, Zlín 1, Zlin, Czechia

Status

Recruiting

Address

PV MEDICAL Services s.r.o. /ID# 215119

Zlín 1, Zlin, 760 01

REVMACLINIC s.r.o. /ID# 215153, Brno, Czechia

Status

Recruiting

Address

REVMACLINIC s.r.o. /ID# 215153

Brno, , 611 41

Revmacentrum MUDr. Mostera /ID# 215161, Brno, Czechia

Status

Recruiting

Address

Revmacentrum MUDr. Mostera /ID# 215161

Brno, , 615 00

Revmatologie, s.r.o. /ID# 215309, Brno, Czechia

Status

Recruiting

Address

Revmatologie, s.r.o. /ID# 215309

Brno, , 638 00

CCR Ostrava s.r.o. /ID# 215226, Ostrava 2, Czechia

Status

Recruiting

Address

CCR Ostrava s.r.o. /ID# 215226

Ostrava 2, , 702 00

ARTHROHELP, s.r.o. /ID# 215224, Pardubice, Czechia

Status

Recruiting

Address

ARTHROHELP, s.r.o. /ID# 215224

Pardubice, , 530 02

Medical Plus, s.r.o. /ID# 215324, Uherské Hradište, Czechia

Status

Recruiting

Address

Medical Plus, s.r.o. /ID# 215324

Uherské Hradište, , 686 01

CHU Toulouse /ID# 214780, Toulouse CEDEX 3, Occitanie, France

Status

Recruiting

Address

CHU Toulouse /ID# 214780

Toulouse CEDEX 3, Occitanie, 31025

Bordeaux, France

Status

Recruiting

Address

CHU Bordeaux-Hopital Pellegrin /ID# 214784

Bordeaux, , 33076

Hopital Ambroise Pare /ID# 214783, Boulogne Billancourt, France

Status

Recruiting

Address

Hopital Ambroise Pare /ID# 214783

Boulogne Billancourt, , 92104

Groupe Hospitalier Cochin /ID# 214782, Paris, France

Status

Recruiting

Address

Groupe Hospitalier Cochin /ID# 214782

Paris, , 75014

Erlangen, Bayern, Germany

Status

Recruiting

Address

Universitaetsklinikum Erlangen /ID# 214281

Erlangen, Bayern, 91054

Berlin, Germany

Status

Recruiting

Address

Rheumatologische Schwerpunktpraxis Brandt-Juergens /ID# 214282

Berlin, , 12161

Berlin, Germany

Status

Recruiting

Address

Charite-Univ. Berlin, Benjamin-Franklin /ID# 214211

Berlin, , 12203

Cottbus, Germany

Status

Recruiting

Address

Rheuma Research Lausitz, Dr. Mario Sutowicz /ID# 214218

Cottbus, , 30342

Dresden, Germany

Status

Recruiting

Address

Universitaetsklinikum Dresden /ID# 214207

Dresden, , 01307

Erlangen, Germany

Status

Recruiting

Address

Praxisgemeinschaft Rheumatologie /ID# 214212

Erlangen, , 91056

Hamburg, Germany

Status

Recruiting

Address

Hamburger Rheuma Forschungszentrum II im MVZ Rheumatologie und Autoimmunmedizin /ID# 214208

Hamburg, , 20095

Med Hochschule Hanover /ID# 214209, Hannover, Germany

Status

Recruiting

Address

Med Hochschule Hanover /ID# 214209

Hannover, , 30625

MVZ Planegg /ID# 214261, Planegg, Germany

Status

Recruiting

Address

MVZ Planegg /ID# 214261

Planegg, , 82152

Rehavita Kft /ID# 215188, Zalaegerszeg, Zala, Hungary

Status

Recruiting

Address

Rehavita Kft /ID# 215188

Zalaegerszeg, Zala, 8900

Budapest, Hungary

Status

Recruiting

Address

Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz /ID# 215183

Budapest, , 1023

Debrecen, Hungary

Status

Recruiting

Address

Debreceni Egyetem Klinikai Kozpont /ID# 215187

Debrecen, , 4032

Gyula, Hungary

Status

Recruiting

Address

Bekes Megyei Pandy Kalman Korhaz /ID# 215186

Gyula, , 5700

Heviz, Hungary

Status

Recruiting

Address

Hevizgyogyfurdo es Szent Andras Reumakorhaz /ID# 215184

Heviz, , 8380

Kistarcsa, Hungary

Status

Recruiting

Address

Pest Megyei Flor Ferenc Korhaz /ID# 214501

Kistarcsa, , 2143

Szekesfehervar, Hungary

Status

Recruiting

Address

CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 215181

Szekesfehervar, , 8000

Veszprem, Hungary

Status

Recruiting

Address

Vital Medical Center Orvosi-es Fogaszati Kozpont /ID# 215182

Veszprem, , 8200

Tel Aviv-Yafo, Tel-Aviv, Israel

Status

Recruiting

Address

Tel Aviv Sourasky Medical Center /ID# 216956

Tel Aviv-Yafo, Tel-Aviv, 6423906

Bnai Zion Medical Center /ID# 215856, Haifa, Israel

Status

Recruiting

Address

Bnai Zion Medical Center /ID# 215856

Haifa, , 3339419

Meir Medical Center /ID# 217255, Kfar Saba, Israel

Status

Recruiting

Address

Meir Medical Center /ID# 217255

Kfar Saba, , 4428164

Sheba Medical Center /ID# 215854, Ramat Gan, Israel

Status

Recruiting

Address

Sheba Medical Center /ID# 215854

Ramat Gan, , 5239424

Bari, Italy

Status

Not yet recruiting

Address

A.O.U. Consorziale Policlinico di Bari /ID# 215072

Bari, , 70124

IRCCS Ospedale San Raffaele /ID# 215071, Milan, Italy

Status

Not yet recruiting

Address

IRCCS Ospedale San Raffaele /ID# 215071

Milan, , 20132

Potenza, Italy

Status

Not yet recruiting

Address

Azienda Ospedaliera Regionale San Carlo /ID# 215067

Potenza, , 85100

A.O. Ordine Mauriziano /ID# 215073, Turin, Italy

Status

Not yet recruiting

Address

A.O. Ordine Mauriziano /ID# 215073

Turin, , 10128

ASST Sette Laghi /ID# 215069, Varese, Italy

Status

Not yet recruiting

Address

ASST Sette Laghi /ID# 215069

Varese, , 21100

Daido Clinic /ID# 214735, Nagoya-shi, Aichi, Japan

Status

Recruiting

Address

Daido Clinic /ID# 214735

Nagoya-shi, Aichi, 457-0818

Matsuyama Red Cross Hospital /ID# 216021, Matsuyama-shi, Ehime, Japan

Status

Recruiting

Address

Matsuyama Red Cross Hospital /ID# 216021

Matsuyama-shi, Ehime, 790-8524

Asahikawa-shi, Hokkaido, Japan

Status

Recruiting

Address

National Hospital Organization Asahikawa Medical Center /ID# 214930

Asahikawa-shi, Hokkaido, 070-8644

Hokkaido University Hospital /ID# 215221, Sapporo-shi, Hokkaido, Japan

Status

Recruiting

Address

Hokkaido University Hospital /ID# 215221

Sapporo-shi, Hokkaido, 060-8648

Kobe University Hospital /ID# 214598, Kobe-shi, Hyogo, Japan

Status

Recruiting

Address

Kobe University Hospital /ID# 214598

Kobe-shi, Hyogo, 650-0017

Nishinomiya-shi, Hyogo, Japan

Status

Recruiting

Address

Hyogo College of Medicine College Hospital /Id# 215638

Nishinomiya-shi, Hyogo, 663-8501

Kita-harima Medical Center /ID# 216069, Ono-shi, Hyogo, Japan

Status

Recruiting

Address

Kita-harima Medical Center /ID# 216069

Ono-shi, Hyogo, 675-1327

Kuwana City Medical Center /ID# 215196, Kuwana-shi, Mie, Japan

Status

Recruiting

Address

Kuwana City Medical Center /ID# 215196

Kuwana-shi, Mie, 511-0061

Nagasaki University Hospital /ID# 215947, Nagasaki-shi, Nagasaki, Japan

Status

Recruiting

Address

Nagasaki University Hospital /ID# 215947

Nagasaki-shi, Nagasaki, 852-8501

Sasebo Chuo Hospital /ID# 214703, Sasebo-shi, Nagasaki, Japan

Status

Recruiting

Address

Sasebo Chuo Hospital /ID# 214703

Sasebo-shi, Nagasaki, 857-1195

Okayama-shi, Okayama, Japan

Status

Recruiting

Address

Japanese Red Cross Okayama Hospital /ID# 214732

Okayama-shi, Okayama, 7008607

Uruma-shi, Okinawa, Japan

Status

Recruiting

Address

Okinawa Prefectural Chubu Hospital /ID# 215575

Uruma-shi, Okinawa, 904-2293

Kawachinagano-shi, Osaka, Japan

Status

Recruiting

Address

National Hospital Organization Osaka Minami Medical Center /ID# 214205

Kawachinagano-shi, Osaka, 586-8521

Osaka City General Hospital /ID# 215640, Osaka-shi, Osaka, Japan

Status

Recruiting

Address

Osaka City General Hospital /ID# 215640

Osaka-shi, Osaka, 534-0021

Juntendo University Hospital /ID# 214929, Bunkyo-ku, Tokyo, Japan

Status

Recruiting

Address

Juntendo University Hospital /ID# 214929

Bunkyo-ku, Tokyo, 113-8431

Chuo-ku, Tokyo, Japan

Status

Recruiting

Address

St.Luke's International Hospital /ID# 215414

Chuo-ku, Tokyo, 104-8560

Ajou University Hospital /ID# 214533, Suwon-si, Gyeonggido, Korea, Republic of

Status

Recruiting

Address

Ajou University Hospital /ID# 214533

Suwon-si, Gyeonggido, 16499

Incheon, Incheon Gwang Yeogsi, Korea, Republic of

Status

Recruiting

Address

Gachon University Gil Medical Center /ID# 214534

Incheon, Incheon Gwang Yeogsi, 21565

Seongdong-gu, Seoul Teugbyeolsi, Korea, Republic of

Status

Recruiting

Address

Hanyang University Seoul Hospi /ID# 214297

Seongdong-gu, Seoul Teugbyeolsi, 04763

Seoul, Seoul Teugbyeolsi, Korea, Republic of

Status

Recruiting

Address

Cath Univ Seoul St Mary's Hosp /ID# 214295

Seoul, Seoul Teugbyeolsi, 06591

Seoul, Korea, Republic of

Status

Recruiting

Address

Seoul National University Hospital /ID# 214532

Seoul, , 03080

Seoul, Korea, Republic of

Status

Recruiting

Address

Kyung Hee University Hospital at Gangdong /ID# 214296

Seoul, , 05278

Asan Medical Center /ID# 214294, Seoul, Korea, Republic of

Status

Recruiting

Address

Asan Medical Center /ID# 214294

Seoul, , 05505

Mexico City, Ciudad De Mexico, Mexico

Status

Not yet recruiting

Address

CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 215217

Mexico City, Ciudad De Mexico, 11850

Guadalajara, Jalisco, Mexico

Status

Not yet recruiting

Address

Centro Integral en Reumatologia S.A de C.V /ID# 215218

Guadalajara, Jalisco, 44160

Guadalajara, Jalisco, Mexico

Status

Not yet recruiting

Address

Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 215257

Guadalajara, Jalisco, 44650

Waikato Hospital /ID# 215503, Hamilton, Waikato, New Zealand

Status

Recruiting

Address

Waikato Hospital /ID# 215503

Hamilton, Waikato, 3204

Middlemore Clinical Trials /ID# 215502, Auckland, New Zealand

Status

Recruiting

Address

Middlemore Clinical Trials /ID# 215502

Auckland, , 2025

Wrocław, Dolnoslaskie, Poland

Status

Recruiting

Address

WroMedica I. Bielicka, A. Strzalkowska s.c. /ID# 215093

Wrocław, Dolnoslaskie, 51-685

Torun, Kujawsko-pomorskie, Poland

Status

Recruiting

Address

Nasz Lekarz Przychodnie Medyczne /ID# 214352

Torun, Kujawsko-pomorskie, 87-100

Osteo-Medic S.C. /ID# 214351, Białystok, Podlaskie, Poland

Status

Recruiting

Address

Osteo-Medic S.C. /ID# 214351

Białystok, Podlaskie, 15-351

Olsztyn, Warminsko-mazurskie, Poland

Status

Recruiting

Address

ETYKA-Osrodek Badan Klinicznych /ID# 215572

Olsztyn, Warminsko-mazurskie, 10-117

Reumed Sp. z o.o. Filia nr 1 /ID# 214353, Lublin, Poland

Status

Recruiting

Address

Reumed Sp. z o.o. Filia nr 1 /ID# 214353

Lublin, , 20-607

Poznań, Poland

Status

Recruiting

Address

AI Centrum Medyczne Sp. z o.o. /ID# 214354

Poznań, , 61-113

Kaliningrad, Kaliningradskaya Oblast, Russian Federation

Status

Recruiting

Address

Immanuel Kant Baltic Federal University /ID# 218259

Kaliningrad, Kaliningradskaya Oblast, 236016

St. Petersburg, Leningradskaya Oblast, Russian Federation

Status

Recruiting

Address

NW State Medical Univ na Mechn /ID# 214454

St. Petersburg, Leningradskaya Oblast, 191015

Korolev, Moskva, Russian Federation

Status

Recruiting

Address

Family Outpatient clinic#4 LLC /ID# 214455

Korolev, Moskva, 141060

RIR named after V.A.Nasonova /ID# 214459, Moscow, Moskva, Russian Federation

Status

Recruiting

Address

RIR named after V.A.Nasonova /ID# 214459

Moscow, Moskva, 115522

LLC Medical Center /ID# 214410, Novosibirsk, Novosibirskaya Oblast, Russian Federation

Status

Recruiting

Address

LLC Medical Center /ID# 214410

Novosibirsk, Novosibirskaya Oblast, 630099

LLC. Family Clinic /ID# 214737, Yekaterinburg, Sverdlovskaya Oblast, Russian Federation

Status

Recruiting

Address

LLC. Family Clinic /ID# 214737

Yekaterinburg, Sverdlovskaya Oblast, 620109

Central City Hospital No.7 /ID# 214741, Yekaterinburg, Sverdlovskaya Oblast, Russian Federation

Status

Recruiting

Address

Central City Hospital No.7 /ID# 214741

Yekaterinburg, Sverdlovskaya Oblast, 620137

Izhevsk, Udmurtskaya Respublika, Russian Federation

Status

Recruiting

Address

Alliance Biomedical Ural Group /ID# 214457

Izhevsk, Udmurtskaya Respublika, 426061

Chelyabinsk, Russian Federation

Status

Recruiting

Address

Chelyabinsk Regional Clinical Hospital /ID# 214463

Chelyabinsk, , 454076

Kazan State University /ID# 214421, Kazan, Russian Federation

Status

Recruiting

Address

Kazan State University /ID# 214421

Kazan, , 42012

Llc Olla-Med /Id# 214460, Moscow, Russian Federation

Status

Recruiting

Address

Llc Olla-Med /Id# 214460

Moscow, , 105554

City Clinical Hospital #15 /ID# 214486, Moscow, Russian Federation

Status

Recruiting

Address

City Clinical Hospital #15 /ID# 214486

Moscow, , 111539

Omsk, Russian Federation

Status

Recruiting

Address

Omsk Clinical Regional Hospita /ID# 214464

Omsk, , 644111

Orenburg, Russian Federation

Status

Recruiting

Address

Orenburg State Medical Academy /ID# 214408

Orenburg, , 460000

LLC Novaya Clinica /ID# 214420, Pyatigorsk, Russian Federation

Status

Recruiting

Address

LLC Novaya Clinica /ID# 214420

Pyatigorsk, , 357532

Ryazan, Russian Federation

Status

Recruiting

Address

Ryazan State Medical Universit /ID# 214418

Ryazan, , 390026

Sankt-Peterburg, Russian Federation

Status

Recruiting

Address

Clinical Rheumatologic Hospital No 25 /ID# 214488

Sankt-Peterburg, , 190068

Saratov, Russian Federation

Status

Recruiting

Address

Private Healthcare Institution Clinical Hospital RZD - Medicine Saratov /ID# 214465

Saratov, , 410004

Ulyanovsk, Russian Federation

Status

Recruiting

Address

Ulyanovsk Regional Clinical Ho /ID# 214458

Ulyanovsk, , 432000

UNB, Nemocnica Stare Mesto /ID# 214675, Bratislava, Slovakia

Status

Recruiting

Address

UNB, Nemocnica Stare Mesto /ID# 214675

Bratislava, , 811 07

Reum.hapi s.r.o. /ID# 224268, Nove Mesto nad Vahom, Slovakia

Status

Recruiting

Address

Reum.hapi s.r.o. /ID# 224268

Nove Mesto nad Vahom, , 915 01

Piestany, Slovakia

Status

Recruiting

Address

Narodny ustav reumatickych chorob /ID# 214674

Piestany, , 921 12

Poprad, Slovakia

Status

Recruiting

Address

MUDr. Zuzana Cizmarikova s.r.o. /ID# 215220

Poprad, , 058 01

ALBAMED s.r.o. /ID# 215248, Zvolen, Slovakia

Status

Recruiting

Address

ALBAMED s.r.o. /ID# 215248

Zvolen, , 960 01

Hospital Marina Baixa /ID# 215970, Villajoyosa, Alicante, Spain

Status

Recruiting

Address

Hospital Marina Baixa /ID# 215970

Villajoyosa, Alicante, 03570

Sabadell, Barcelona, Spain

Status

Recruiting

Address

Hospital Parc Tauli de Sabadell /ID# 214967

Sabadell, Barcelona, 08208

Santander, Cantabria, Spain

Status

Recruiting

Address

Hospital Unversitario Marques de Valdecilla /ID# 214965

Santander, Cantabria, 39008

Hospital Meixoeiro (CHUVI) /ID# 214969, Vigo, Pontevedra, Spain

Status

Recruiting

Address

Hospital Meixoeiro (CHUVI) /ID# 214969

Vigo, Pontevedra, 36213

Cordoba, Spain

Status

Recruiting

Address

Hospital Universitario Reina Sofia /ID# 214968

Cordoba, , 14004

Madrid, Spain

Status

Recruiting

Address

Hospital Universitario La Paz /ID# 216032

Madrid, , 28046

Valencia, Spain

Status

Recruiting

Address

Hospital Universitario y Politecnico La Fe /ID# 214966

Valencia, , 46026

Kaohsiung, Taichung, Taiwan

Status

Recruiting

Address

Kaohsiung Veterans General Hos /ID# 214332

Kaohsiung, Taichung, 81362

Taichung City, Taichung, Taiwan

Status

Recruiting

Address

China Medical University Hosp /ID# 214019

Taichung City, Taichung, 40447

New Taipei City, Taiwan

Status

Recruiting

Address

Far Eastern Memorial Hospital /ID# 215384

New Taipei City, , 22060

Taichung City, Taiwan

Status

Recruiting

Address

Chung Shan Medical University /ID# 214018

Taichung City, , 40201

Cathay General Hospital /ID# 214183, Taipei City, Taiwan

Status

Recruiting

Address

Cathay General Hospital /ID# 214183

Taipei City, , 10630

Sihhiye, Ankara, Turkey

Status

Recruiting

Address

Hacettepe Universitesi Tip Fak /ID# 214898

Sihhiye, Ankara, 06100

Cerrahpasa, Turkey

Status

Recruiting

Address

Istanbul University Cerrahpasa Faculty of Medicine /ID# 214895

Cerrahpasa, , 34098

Mugla, Turkey

Status

Recruiting

Address

Mugla Sitki Kocman University Medical Faculty /ID# 215358

Mugla, , 48000

Vinnytsia, Vinnytska Oblast, Ukraine

Status

Recruiting

Address

Scientific Research Institute of Invalid Rehabilitation /ID# 214148

Vinnytsia, Vinnytska Oblast, 21029

Chernihiv, Ukraine

Status

Recruiting

Address

MNPE Chernihiv Regional Hospital of the Chernihiv Region Council /ID# 214145

Chernihiv, , 14029

Kharkiv, Ukraine

Status

Recruiting

Address

PNE City Multifunctional Hospital No.18 /ID# 214154

Kharkiv, , 61029

Kharkiv, Ukraine

Status

Recruiting

Address

SI L.T. Malaya Therapy National Institution of NAMS of Ukraine /ID# 214155

Kharkiv, , 61039

Kharkiv, Ukraine

Status

Recruiting

Address

Kharkiv Regional Council Regional Clinical Hospital /ID# 214158

Kharkiv, , 61058

Khmelnitskyi, Ukraine

Status

Recruiting

Address

MNI Khmelnitskyi Regional Hospital /ID# 214153

Khmelnitskyi, , 29000

Kryvyi Rih, Ukraine

Status

Recruiting

Address

MI Kryvyi Rih City Clinical Hospital No.2 /ID# 214152

Kryvyi Rih, , 50056

Kyiv, Ukraine

Status

Recruiting

Address

Kyiv Railway Clinical Hosp No.2 /ID# 214779

Kyiv, , 03049

Kyiv, Ukraine

Status

Recruiting

Address

Medical centre of CONSILIUM MEDICAL LLC /ID# 216234

Kyiv, , 04050

LLC Revmocentr /ID# 214146, Kyiv, Ukraine

Status

Recruiting

Address

LLC Revmocentr /ID# 214146

Kyiv, , 04070

Kyiv, Ukraine

Status

Recruiting

Address

MNI KRC Kyiv Regional Clinical Hospital /ID# 214156

Kyiv, , 04107

Odesa, Ukraine

Status

Recruiting

Address

MNI Odesa Regional Clinical Hospital of ORC /ID# 214159

Odesa, , 65025

Poltava, Ukraine

Status

Recruiting

Address

Poltava Reg Clin Hosp Sklifoso /ID# 214151

Poltava, , 36011

Ternopil University Hospital /ID# 214705, Ternopil, Ukraine

Status

Recruiting

Address

Ternopil University Hospital /ID# 214705

Ternopil, , 46002

Vinnytsia, Ukraine

Status

Recruiting

Address

Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 214147

Vinnytsia, , 21018

Оdesa, Ukraine

Status

Recruiting

Address

Multifield Medical Centre of ONMU /ID# 214149

Оdesa, , 65026

Norwich, Norfolk, United Kingdom

Status

Recruiting

Address

Norfolk and Norwich Univ Hosp /ID# 214865

Norwich, Norfolk, NR4 7UY

West Suffolk Hospital /ID# 215529, Bury St Edmunds, United Kingdom

Status

Recruiting

Address

West Suffolk Hospital /ID# 215529

Bury St Edmunds, , IP33 2QZ

Doncaster Royal Infirmary /ID# 214971, Doncaster, United Kingdom

Status

Recruiting

Address

Doncaster Royal Infirmary /ID# 214971

Doncaster, , DN2 5LT

Preston, United Kingdom

Status

Recruiting

Address

Lancashire Care NHS Foundation /ID# 216226

Preston, , BT47 3EN