A Study to Investigate the Safety and Efficacy of Elsubrutinib and Upadacitinib Given Alone or in Combination in Participants With Moderately to Severely Active Systemic Lupus Erythematosus (SLE)

Study Purpose

The main objective of this study is to evaluate the safety and efficacy of elsubrutinib, upadacitinib, and ABBV-599 vs.#46;placebo for the treatment of signs and symptoms of Systemic Lupus Erythematosus (SLE) in participants with moderately to severely active SLE and to define doses for further development.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years - 65 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Participant has clinical diagnosis of SLE at least 24 weeks prior to screening, meeting at least 4 of the 11 revised Criteria for Classification of SLE according to the 1997 Update of the 1982 American College of Rheumatology (ACR) OR meeting at least 4 of the 2012 SLICC classification criteria, including at least 1 clinical criterion and 1 immunologic criterion.
  • - At Screening, must have at least one of the following: - antinuclear antibody(ANA)+ (titer >= 1:80).
  • - anti-dsDNA+.
  • - anti-Smith+.
  • - SLEDAI-2K >= 6 despite background therapy as reported and independently adjudicated (clinical score >= 4, excluding lupus headache and/or organic brain syndrome) at Screening.
  • - If 4 points of the required entry points are for arthritis, there must also be a minimum of 3 tender and 3 swollen joints.
  • - If participant has rash and PI considers it to be attributable to SLE, participant must consent to skin photograph collection for adjudication.
  • - Score must be re-confirmed at the Baseline visit.
  • - Physician's Global Assessment (PhGA) >= 1 during screening period.
  • - Must be on background treatment, stable for 30 days, at Baseline and throughout the study with antimalarial(s), prednisone (or prednisone equivalent) (<=20 mg), azathioprine (<= 150 mg), mycophenolate (<2 g), leflunomide (<=20 mg), cyclosporine, tacrolimus, and/or methotrexate (MTX) (<=20 mg).
  • - No combinations of the above with immunomodulators other than prednisone (or equivalents) and antimalarials.

Exclusion Criteria:

  • - Participant using intravenous (IV) or intramuscular (IM) corticosteroids greater than or equal to a 40 mg prednisone-equivalent bolus within 30 days of planned randomization.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03978520
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

AbbVie
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

AbbVie Inc.
Principal Investigator Affiliation AbbVie
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Australia, Bulgaria, Canada, China, Colombia, France, Germany, Hungary, Italy, Japan, Korea, Republic of, Mexico, Netherlands, New Zealand, Poland, Puerto Rico, Spain, Taiwan, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Systemic Lupus Erythematosus (SLE)
Study Website: View Trial Website
Arms & Interventions

Arms

Experimental: Group 1: Upadacitinib and Elsubrutinib

Participants will be administered with elsubrutinib dose A and upadacitinib dose A.

Experimental: Group 2: Upadacitinib and Elsubrutinib

Participants will be administered with elsubrutinib dose A and upadacitinib dose B.

Experimental: Group 3: Elsubrutinib and Placebo for Updadacitinib

Participants will be administered with elsubrutinib dose A and placebo for upadacitinib.

Experimental: Group 4: Upadacitinib and Placebo for Elsubrutinib

Participants will be administered with placebo for elsubrutinib and upadacitinib dose A.

Experimental: Group 5: Placebo for Elsubrutinib and Placebo for Upadacitinib

Participants will be administered with placebo for elsubrutinib and placebo for upadacitinib.

Interventions

Drug: - Elsubrutinib

Capsule; Oral

Drug: - Placebo for Elsubrutinib

Capsule; Oral

Drug: - Upadacitinib

Tablet; Oral

Drug: - Placebo for upadacitinib

Tablet; Oral

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Mesa, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatology Research, PLLC /ID# 214522

Mesa, Arizona, 85210-6871

Phoenix, Arizona

Status

Recruiting

Address

Arizona Arthritis & Rheumatolo /ID# 211329

Phoenix, Arizona, 85032-9306

Phoenix, Arizona

Status

Recruiting

Address

AZ Arthritis & Rheuma Research /ID# 214267

Phoenix, Arizona, 85032

Jonesboro, Arkansas

Status

Recruiting

Address

Arthritis and Rheumatism Associates /ID# 211411

Jonesboro, Arkansas, 72401

Beverly Hills, California

Status

Recruiting

Address

Wallace Rheumatic Studies Ctr /ID# 211600

Beverly Hills, California, 90211

Valerius Medical Group /ID# 211599, Los Alamitos, California

Status

Recruiting

Address

Valerius Medical Group /ID# 211599

Los Alamitos, California, 90720

San Leandro, California

Status

Recruiting

Address

East Bay Rheumatology Medical /ID# 211638

San Leandro, California, 94578

Torrance, California

Status

Recruiting

Address

The Lundquist Institute at Harbor-UCLA Medical Center /ID# 213402

Torrance, California, 90502

Medvin Clinical Research /ID# 211996, Tujunga, California

Status

Recruiting

Address

Medvin Clinical Research /ID# 211996

Tujunga, California, 91042-2706

Upland, California

Status

Recruiting

Address

Inland Rheum Clin Trials Inc. /ID# 213617

Upland, California, 91786

Denver, Colorado

Status

Recruiting

Address

University of Colorado Hospita /ID# 211314

Denver, Colorado, 80045

Yale University /ID# 212824, New Haven, Connecticut

Status

Recruiting

Address

Yale University /ID# 212824

New Haven, Connecticut, 06510

Washington, District of Columbia

Status

Completed

Address

Medstar Health Research Institute /ID# 213335

Washington, District of Columbia, 20010

Aventura, Florida

Status

Recruiting

Address

Arthritis & Rheumatic Disease Specialties /ID# 214052

Aventura, Florida, 33180

LeJenue Research Associates /ID# 212327, Miami, Florida

Status

Completed

Address

LeJenue Research Associates /ID# 212327

Miami, Florida, 33126

Miami, Florida

Status

Recruiting

Address

Ctr Arthritis & Rheumatic Dise /ID# 212326

Miami, Florida, 33173

Millennium Research /ID# 219099, Ormond Beach, Florida

Status

Recruiting

Address

Millennium Research /ID# 219099

Ormond Beach, Florida, 32174

Plantation, Florida

Status

Recruiting

Address

IRIS Research and Development, LLC /ID# 213053

Plantation, Florida, 33324

W. Broward Rheum Assoc Inc. /ID# 211881, Tamarac, Florida

Status

Recruiting

Address

W. Broward Rheum Assoc Inc. /ID# 211881

Tamarac, Florida, 33321

BayCare Medical Group, Inc. /ID# 218818, Tampa, Florida

Status

Recruiting

Address

BayCare Medical Group, Inc. /ID# 218818

Tampa, Florida, 33614-7101

Affinity Health /ID# 211496, Oak Brook, Illinois

Status

Recruiting

Address

Affinity Health /ID# 211496

Oak Brook, Illinois, 60523-1245

Deerbrook Medical Associates /ID# 212251, Vernon Hills, Illinois

Status

Recruiting

Address

Deerbrook Medical Associates /ID# 212251

Vernon Hills, Illinois, 60061

Evansville, Indiana

Status

Recruiting

Address

Rheumatology, Arthritis & Immunology Clinic /ID# 214765

Evansville, Indiana, 47714-0805

Iowa City, Iowa

Status

Not yet recruiting

Address

University of Iowa Hospitals and Clinics /ID# 215246

Iowa City, Iowa, 52242

LSUHSC - Shreveport /ID# 211412, Shreveport, Louisiana

Status

Not yet recruiting

Address

LSUHSC - Shreveport /ID# 211412

Shreveport, Louisiana, 71103

Wheaton, Maryland

Status

Recruiting

Address

The Center for Rheumatology and Bone Research /ID# 211610

Wheaton, Maryland, 20902

Boston, Massachusetts

Status

Recruiting

Address

Beth Israel Deaconess Medical Center /ID# 212321

Boston, Massachusetts, 02215-5400

Henry Ford Health System /ID# 211676, Detroit, Michigan

Status

Recruiting

Address

Henry Ford Health System /ID# 211676

Detroit, Michigan, 48202

June DO, PC /ID# 211674, Lansing, Michigan

Status

Recruiting

Address

June DO, PC /ID# 211674

Lansing, Michigan, 48910

West County Rheumatology /ID# 225051, Saint Louis, Missouri

Status

Not yet recruiting

Address

West County Rheumatology /ID# 225051

Saint Louis, Missouri, 63131-1703

Brooklyn, New York

Status

Recruiting

Address

NYU Langone Ambulatory Care Brooklyn Heights /ID# 211548

Brooklyn, New York, 11201

New York, New York

Status

Recruiting

Address

NYU Langone Orthopedic Center /ID# 213620

New York, New York, 10016-2772

Columbus, Ohio

Status

Recruiting

Address

Ohio State University - Wexner Medical Center /ID# 211636

Columbus, Ohio, 43210-1229

STAT Research, Inc. /ID# 211404, Vandalia, Ohio

Status

Recruiting

Address

STAT Research, Inc. /ID# 211404

Vandalia, Ohio, 45377-9464

Tulsa, Oklahoma

Status

Recruiting

Address

Premier Rheumatology of Oklahoma - Tulsa /ID# 213850

Tulsa, Oklahoma, 74136-2117

Allegheny Health Network /ID# 211607, Pittsburgh, Pennsylvania

Status

Recruiting

Address

Allegheny Health Network /ID# 211607

Pittsburgh, Pennsylvania, 15212-4769

Univ TN Health Sciences Ctr /ID# 212177, Memphis, Tennessee

Status

Recruiting

Address

Univ TN Health Sciences Ctr /ID# 212177

Memphis, Tennessee, 38103

Dr. Ramesh Gupta /ID# 213381, Memphis, Tennessee

Status

Recruiting

Address

Dr. Ramesh Gupta /ID# 213381

Memphis, Tennessee, 38119

Tekton Research, Inc. /ID# 211521, Austin, Texas

Status

Recruiting

Address

Tekton Research, Inc. /ID# 211521

Austin, Texas, 78745

Tekton Research, Inc. /ID# 214182, Austin, Texas

Status

Recruiting

Address

Tekton Research, Inc. /ID# 214182

Austin, Texas, 78745

Trinity Universal Res Assoc /ID# 211527, Carrollton, Texas

Status

Recruiting

Address

Trinity Universal Res Assoc /ID# 211527

Carrollton, Texas, 75007

Accurate Clinical Management /ID# 213571, Houston, Texas

Status

Recruiting

Address

Accurate Clinical Management /ID# 213571

Houston, Texas, 77004

West Texas Clinical Research /ID# 211529, Lubbock, Texas

Status

Recruiting

Address

West Texas Clinical Research /ID# 211529

Lubbock, Texas, 79410-1198

SW Rheumatology Res. LLC /ID# 211520, Mesquite, Texas

Status

Recruiting

Address

SW Rheumatology Res. LLC /ID# 211520

Mesquite, Texas, 75150

Carilion Clinic /ID# 213500, Roanoke, Virginia

Status

Recruiting

Address

Carilion Clinic /ID# 213500

Roanoke, Virginia, 24016

Seattle, Washington

Status

Recruiting

Address

Virginia Mason Medical Center /ID# 211457

Seattle, Washington, 98101

Beckley, West Virginia

Status

Recruiting

Address

Rheumatology and Pulmonary cli /ID# 211398

Beckley, West Virginia, 25801

International Sites

Capital Federal, Buenos Aires, Argentina

Status

Recruiting

Address

Aprillus Asistencia e Investig /ID# 211630

Capital Federal, Buenos Aires, 1046

La Plata, Buenos Aires, Argentina

Status

Recruiting

Address

Hospital Interzonal Gral Agudos San Martin /ID# 211679

La Plata, Buenos Aires, 1906

CER Instituto Medico /ID# 222757, Quilmes, Buenos Aires, Argentina

Status

Recruiting

Address

CER Instituto Medico /ID# 222757

Quilmes, Buenos Aires, 1878

Ciudad Autonoma Buenos Aires, Ciuadad Autonoma De Buenos Aires, Argentina

Status

Not yet recruiting

Address

Consultorio Medico Dra. Rivera /ID# 221885

Ciudad Autonoma Buenos Aires, Ciuadad Autonoma De Buenos Aires, 1426

Centro Medico Privado/Reuma /ID# 212714, San Miguel de Tucuman, Tucuman, Argentina

Status

Recruiting

Address

Centro Medico Privado/Reuma /ID# 212714

San Miguel de Tucuman, Tucuman, 4000

Buenos Aires, Argentina

Status

Recruiting

Address

Hospital Militar Central Ciruj /ID# 221685

Buenos Aires, , 1426

Hospital Cordoba /ID# 212200, Cordoba, Argentina

Status

Recruiting

Address

Hospital Cordoba /ID# 212200

Cordoba, , 5000

Instituto CAICI /ID# 211633, Rosario Santa FE, Argentina

Status

Recruiting

Address

Instituto CAICI /ID# 211633

Rosario Santa FE, , 2000

Investigaciones Clin Tucuman /ID# 211942, San Miguel de Tucuman, Argentina

Status

Recruiting

Address

Investigaciones Clin Tucuman /ID# 211942

San Miguel de Tucuman, , 4000

Santa Fe, Argentina

Status

Recruiting

Address

Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 211634

Santa Fe, , 2000

Emeritus Research Sydney /ID# 222983, Botany, New South Wales, Australia

Status

Recruiting

Address

Emeritus Research Sydney /ID# 222983

Botany, New South Wales, 2019

Royal North Shore Hospital /ID# 222982, Saint Leonards, New South Wales, Australia

Status

Not yet recruiting

Address

Royal North Shore Hospital /ID# 222982

Saint Leonards, New South Wales, 2065

Herston, Queensland, Australia

Status

Recruiting

Address

Royal Brisbane and Women's Hospital /ID# 212667

Herston, Queensland, 4029

Rheumatology Research Unit /ID# 211902, Maroochydore, Queensland, Australia

Status

Recruiting

Address

Rheumatology Research Unit /ID# 211902

Maroochydore, Queensland, 4558

Griffith University /ID# 223543, Southport, Queensland, Australia

Status

Recruiting

Address

Griffith University /ID# 223543

Southport, Queensland, 4222

The Queen Elizabeth Hospital /ID# 211901, Woodville, South Australia, Australia

Status

Recruiting

Address

The Queen Elizabeth Hospital /ID# 211901

Woodville, South Australia, 5011

Emeritus Research /ID# 211903, Camberwell, Victoria, Australia

Status

Recruiting

Address

Emeritus Research /ID# 211903

Camberwell, Victoria, 3124

Monash Health /ID# 212313, Clayton, Victoria, Australia

Status

Recruiting

Address

Monash Health /ID# 212313

Clayton, Victoria, 3168

St. Vincents Hosp Melbourne /ID# 212311, Fitzroy, Victoria, Australia

Status

Recruiting

Address

St. Vincents Hosp Melbourne /ID# 212311

Fitzroy, Victoria, 3065

MHAT Kaspela /ID# 223141, Plovdiv, Bulgaria

Status

Not yet recruiting

Address

MHAT Kaspela /ID# 223141

Plovdiv, , 4001

UMHAT Sv. Ivan Rilski /ID# 223139, Sofia, Bulgaria

Status

Not yet recruiting

Address

UMHAT Sv. Ivan Rilski /ID# 223139

Sofia, , 1612

UMHAT Sv. Ivan Rilski /ID# 223140, Sofia, Bulgaria

Status

Recruiting

Address

UMHAT Sv. Ivan Rilski /ID# 223140

Sofia, , 1612

McMaster University Med Cent /ID# 212662, Hamilton, Ontario, Canada

Status

Recruiting

Address

McMaster University Med Cent /ID# 212662

Hamilton, Ontario, L8S 4K1

London, Ontario, Canada

Status

Recruiting

Address

St. Josephs Health Care Centre /ID# 212331

London, Ontario, N6A 4V2

Toronto Western Hospital /ID# 213336, Toronto, Ontario, Canada

Status

Recruiting

Address

Toronto Western Hospital /ID# 213336

Toronto, Ontario, M5T 2S8

Sherbrooke, Quebec, Canada

Status

Recruiting

Address

Diex Recherche Sherbrooke Inc. /ID# 217734

Sherbrooke, Quebec, J1L 0H8

Anhui Provincial Hospital /ID# 211812, Hefei, Anhui, China

Status

Recruiting

Address

Anhui Provincial Hospital /ID# 211812

Hefei, Anhui, 230001

Guangzhou, Guangdong, China

Status

Recruiting

Address

Guangdong Provincial People's Hospital /ID# 211811

Guangzhou, Guangdong, 510080

Changsha, Hunan, China

Status

Recruiting

Address

Xiangya Hospital Central South University /ID# 212919

Changsha, Hunan, 410008

Shanghai Changhai Hospital /ID# 211819, Shanghai, Shanghai, China

Status

Recruiting

Address

Shanghai Changhai Hospital /ID# 211819

Shanghai, Shanghai, 200433

Beijing, China

Status

Recruiting

Address

Peking Union Med College Hosp /ID# 211614

Beijing, , 100730

Jiangsu Province Hospital /ID# 211818, Nanjing, China

Status

Not yet recruiting

Address

Jiangsu Province Hospital /ID# 211818

Nanjing, , 210029

Shanghai, China

Status

Recruiting

Address

Huashan Hospital of Fudan University /ID# 213976

Shanghai, , 200040

Urumqi, China

Status

Recruiting

Address

People's Hospital of Xinjiang /ID# 211821

Urumqi, , 830001

Bogota, Cundinamarca, Colombia

Status

Recruiting

Address

Centro de Investigacion en Reumatologia CIREEM /ID# 211895

Bogota, Cundinamarca, 110231

Barranquilla, Colombia

Status

Recruiting

Address

Ctr Int de Reum del Caribe SAS /ID# 211894

Barranquilla, , 80002

Preventive Care Sas /Id# 211896, Chia, Colombia

Status

Recruiting

Address

Preventive Care Sas /Id# 211896

Chia, , 250001

Medellin, Colombia

Status

Recruiting

Address

Clinica Universitaria Bolivari /ID# 211897

Medellin, , 050034

Healthy Medical Center SAS /ID# 211899, Zipaquira, Colombia

Status

Recruiting

Address

Healthy Medical Center SAS /ID# 211899

Zipaquira, , 250252

Lille CEDEX, Hauts-de-France, France

Status

Recruiting

Address

CHRU Lille - Hopital Claude Huriez /ID# 211829

Lille CEDEX, Hauts-de-France, 59045

Bordeaux, France

Status

Recruiting

Address

CHU Bordeaux-Hopital Pellegrin /ID# 211832

Bordeaux, , 33076

CHU Bicetre /ID# 211968, Le Kremlin Bicetre, France

Status

Recruiting

Address

CHU Bicetre /ID# 211968

Le Kremlin Bicetre, , 94270

Paris, France

Status

Recruiting

Address

CHU Paris-GH La Pitie Salpetriere /ID# 211831

Paris, , 75013

Hôpital Civil /ID# 211981, Strasbourg CEDEX, France

Status

Recruiting

Address

Hôpital Civil /ID# 211981

Strasbourg CEDEX, , 67091

Dusseldorf, Nordrhein-Westfalen, Germany

Status

Not yet recruiting

Address

Universitaetsklinikum Duesseldorf /ID# 212408

Dusseldorf, Nordrhein-Westfalen, 40225

Berlin, Germany

Status

Recruiting

Address

Charité - Med Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie /ID# 211988

Berlin, , 10117

Dresden, Germany

Status

Recruiting

Address

Universitaetsklinikum Dresden /ID# 212770

Dresden, , 01307

Univ Hosp Schleswig-Holstein /ID# 212674, Kiel, Germany

Status

Recruiting

Address

Univ Hosp Schleswig-Holstein /ID# 212674

Kiel, , 24105

Budapest, Hungary

Status

Recruiting

Address

Orszagos Reumatologiai es Fizi /ID# 211827

Budapest, , 1023

Debrecen, Hungary

Status

Recruiting

Address

Debreceni Egyetem Klinikai Kozpont /ID# 212042

Debrecen, , 4032

Gyula, Hungary

Status

Recruiting

Address

Bekes Megyei Pandy Kalman Korhaz /ID# 216971

Gyula, , 5700

Veszprem, Hungary

Status

Recruiting

Address

Vital Medical Center Orvosi-es Fogaszati Kozpont /ID# 212796

Veszprem, , 8200

AOU Policlinico Umberto I /ID# 212195, Rome, Lazio, Italy

Status

Not yet recruiting

Address

AOU Policlinico Umberto I /ID# 212195

Rome, Lazio, 00185

AOU Arcispedale Sant Anna di /ID# 211861, Cona, Italy

Status

Not yet recruiting

Address

AOU Arcispedale Sant Anna di /ID# 211861

Cona, , 44124

Milan, Italy

Status

Not yet recruiting

Address

Azienda Istituto Gaetano Pini /ID# 215063

Milan, , 20122

AOU Pisana /ID# 211862, Pisa, Italy

Status

Not yet recruiting

Address

AOU Pisana /ID# 211862

Pisa, , 56124

Udine, Italy

Status

Recruiting

Address

Azienda Sanitaria Universitaria Friuli Centrale /ID# 211858

Udine, , 33100

Chukyo Hospital /ID# 222625, Nagoya-shi, Aichi, Japan

Status

Recruiting

Address

Chukyo Hospital /ID# 222625

Nagoya-shi, Aichi, 457-8510

NHO Nagoya Medical Center /ID# 213974, Nagoya-shi, Aichi, Japan

Status

Recruiting

Address

NHO Nagoya Medical Center /ID# 213974

Nagoya-shi, Aichi, 460-0001

Hamanomachi Hospital /ID# 213696, Fukuoka-shi, Fukuoka, Japan

Status

Recruiting

Address

Hamanomachi Hospital /ID# 213696

Fukuoka-shi, Fukuoka, 810-8539

Kitakyushu-shi, Fukuoka, Japan

Status

Recruiting

Address

Hospital of the University of Occupational and Environmental Health /ID# 217548

Kitakyushu-shi, Fukuoka, 807-8556

Fukushima-shi, Fukushima, Japan

Status

Recruiting

Address

Fukushima Medical University Hospital /ID# 213913

Fukushima-shi, Fukushima, 960-1295

Hiroshima-shi, Hiroshima, Japan

Status

Recruiting

Address

Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital /ID# 213694

Hiroshima-shi, Hiroshima, 730-8619

Asahikawa-shi, Hokkaido, Japan

Status

Recruiting

Address

National Hospital Organization Asahikawa Medical Center /ID# 213846

Asahikawa-shi, Hokkaido, 070-8644

Tomakomai City Hospital /ID# 214234, Tomakomai-shi, Hokkaido, Japan

Status

Recruiting

Address

Tomakomai City Hospital /ID# 214234

Tomakomai-shi, Hokkaido, 053-0034

Kita-harima Medical Center /ID# 215474, Ono-shi, Hyogo, Japan

Status

Recruiting

Address

Kita-harima Medical Center /ID# 215474

Ono-shi, Hyogo, 675-1327

Kagoshima-shi, Kagoshima, Japan

Status

Recruiting

Address

Eiraku Internal Medicine Clinic /ID# 215419

Kagoshima-shi, Kagoshima, 890-0063

Yokohama Rosai Hospital /ID# 213690, Yokohama-shi, Kanagawa, Japan

Status

Recruiting

Address

Yokohama Rosai Hospital /ID# 213690

Yokohama-shi, Kanagawa, 222-0036

Kumamoto-shi, Kumamoto, Japan

Status

Recruiting

Address

Kumamoto Shinto General Hospital /ID# 215347

Kumamoto-shi, Kumamoto, 8628655

Tohoku University Hospital /ID# 213693, Sendai-shi, Miyagi, Japan

Status

Recruiting

Address

Tohoku University Hospital /ID# 213693

Sendai-shi, Miyagi, 980-8574

Shinshu University Hospital /ID# 213853, Matsumoto-shi, Nagano, Japan

Status

Recruiting

Address

Shinshu University Hospital /ID# 213853

Matsumoto-shi, Nagano, 390-8621

Nagano Red Cross Hospital /ID# 214572, Nagano-shi, Nagano, Japan

Status

Recruiting

Address

Nagano Red Cross Hospital /ID# 214572

Nagano-shi, Nagano, 380-8582

Saitama Medical Center /ID# 213687, Kawagoe-shi, Saitama, Japan

Status

Recruiting

Address

Saitama Medical Center /ID# 213687

Kawagoe-shi, Saitama, 350-8550

Keio University Hospital /ID# 216347, Shinjuku-ku, Tokyo, Japan

Status

Recruiting

Address

Keio University Hospital /ID# 216347

Shinjuku-ku, Tokyo, 160-8582

Ajou University Hospital /ID# 211692, Suwon-si, Gyeonggido, Korea, Republic of

Status

Recruiting

Address

Ajou University Hospital /ID# 211692

Suwon-si, Gyeonggido, 16499

Inha University Hospital /ID# 211691, Jung-gu, Incheon Gwang Yeogsi, Korea, Republic of

Status

Recruiting

Address

Inha University Hospital /ID# 211691

Jung-gu, Incheon Gwang Yeogsi, 22332

Gwangju, Jeonranamdo, Korea, Republic of

Status

Recruiting

Address

Chonnam National University Hospital /ID# 211695

Gwangju, Jeonranamdo, 61469

Seoul, Seoul Teugbyeolsi, Korea, Republic of

Status

Recruiting

Address

Konkuk University Medical Ctr /ID# 213410

Seoul, Seoul Teugbyeolsi, 05030

Seoul, Korea, Republic of

Status

Recruiting

Address

Seoul National University Hospital /ID# 211740

Seoul, , 03080

Mexico City, Ciudad De Mexico, Mexico

Status

Recruiting

Address

CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 211875

Mexico City, Ciudad De Mexico, 11850

Leon, Guanajuato, Mexico

Status

Not yet recruiting

Address

Morales Vargas Centro de Investigacion S.C. /ID# 212946

Leon, Guanajuato, 37000

Guadalajara, Jalisco, Mexico

Status

Recruiting

Address

Centro Integral en Reumatologia S.A de C.V /ID# 211876

Guadalajara, Jalisco, 44160

Guadalajara, Jalisco, Mexico

Status

Recruiting

Address

Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 212532

Guadalajara, Jalisco, 44690

San Luis Potosí, San Luis Potosi, Mexico

Status

Not yet recruiting

Address

Centro de Alta Especialidad en Reumatología e Investigación del Potosí, SC /ID# 212737

San Luis Potosí, San Luis Potosi, 78213

Mérida, Yucatan, Mexico

Status

Recruiting

Address

Medical Care & Research SA de CV /ID# 212682

Mérida, Yucatan, 97070

Mexico City, Mexico

Status

Recruiting

Address

RM Pharma Specialists S.A de C.V /ID# 211879

Mexico City, , 03100

Amsterdam, Netherlands

Status

Not yet recruiting

Address

Vrije Universiteit Medisch Centrum /ID# 214424

Amsterdam, , 1081 HV

Leiden, Netherlands

Status

Recruiting

Address

Leids Universitair Medisch Centrum /ID# 214413

Leiden, , 2333 ZA

Utrecht, Netherlands

Status

Recruiting

Address

Universitair Medisch Centrum Utrecht /ID# 214415

Utrecht, , 3584 CX

Waikato Hospital /ID# 213505, Hamilton, Waikato, New Zealand

Status

Recruiting

Address

Waikato Hospital /ID# 213505

Hamilton, Waikato, 3204

North Shore Hospital /ID# 213506, Auckland, New Zealand

Status

Recruiting

Address

North Shore Hospital /ID# 213506

Auckland, , 0622

Middlemore Clinical Trials /ID# 213504, Auckland, New Zealand

Status

Completed

Address

Middlemore Clinical Trials /ID# 213504

Auckland, , 2025

Wrocław, Dolnoslaskie, Poland

Status

Recruiting

Address

WroMedica I. Bielicka, A. Strzalkowska s.c. /ID# 212482

Wrocław, Dolnoslaskie, 51-685

Krakow, Poland

Status

Recruiting

Address

Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o. /ID# 212146

Krakow, , 31-011

Poznań, Poland

Status

Recruiting

Address

Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi /ID# 212483

Poznań, , 61-545

Warsaw, Poland

Status

Recruiting

Address

Centrum Medyczne Pratia Warszawa /ID# 218176

Warsaw, , 01-868

GCM Medical Group, PSC /ID# 211251, San Juan, Puerto Rico

Status

Recruiting

Address

GCM Medical Group, PSC /ID# 211251

San Juan, , 00917

Mindful Medical Research /ID# 213384, San Juan, Puerto Rico

Status

Recruiting

Address

Mindful Medical Research /ID# 213384

San Juan, , 00918-3756

A Coruña, A Coruna, Spain

Status

Recruiting

Address

Hospital Universitario A Coruña - CHUAC /ID# 211719

A Coruña, A Coruna, 15006

Sabadell, Barcelona, Spain

Status

Recruiting

Address

Hospital Parc Tauli de Sabadell /ID# 212145

Sabadell, Barcelona, 08208

Bilbao, Spain

Status

Recruiting

Address

Hospital Universitario Basurto /ID# 212722

Bilbao, , 48013

Galdakao, Spain

Status

Recruiting

Address

Hospital Universitario de Galdakao /ID# 212803

Galdakao, , 48960

Madrid, Spain

Status

Recruiting

Address

Hospital Universitario 12 de Octubre /ID# 211757

Madrid, , 28041

Sevilla, Spain

Status

Recruiting

Address

Hospital Universitario Virgen de Valme /ID# 212721

Sevilla, , 41014

Valencia, Spain

Status

Recruiting

Address

Hospital Universitario y Politecnico La Fe /ID# 211720

Valencia, , 46026

HUA - Txagorritxu /ID# 212520, Vitoria, Spain

Status

Recruiting

Address

HUA - Txagorritxu /ID# 212520

Vitoria, , 01009

Taichung City, Taichung, Taiwan

Status

Recruiting

Address

China Medical University Hosp /ID# 212179

Taichung City, Taichung, 40447

Taipei City, Taipei, Taiwan

Status

Recruiting

Address

National Taiwan University Hospital /ID# 211752

Taipei City, Taipei, 100

Taichung City, Taiwan

Status

Recruiting

Address

Taichung Veterans General Hosp /ID# 211957

Taichung City, , 40705

Taipei City, Taiwan

Status

Recruiting

Address

Taipei Medical University Hospital /ID# 221600

Taipei City, , 11031

Taipei Veterans General Hosp /ID# 212216, Taipei City, Taiwan

Status

Recruiting

Address

Taipei Veterans General Hosp /ID# 212216

Taipei City, , 11217

Taoyuan City, Taiwan

Status

Recruiting

Address

Linkou Chang Gung Memorial Ho /ID# 211751

Taoyuan City, , 33305

Addenbrookes Hospital /ID# 213189, Cambridge, United Kingdom

Status

Not yet recruiting

Address

Addenbrookes Hospital /ID# 213189

Cambridge, , CB2 0SP

Guy's Hospital /ID# 211931, London, United Kingdom

Status

Recruiting

Address

Guy's Hospital /ID# 211931

London, , SE1 9RT

Manchester Royal Infirmary /ID# 211838, Manchester, United Kingdom

Status

Recruiting

Address

Manchester Royal Infirmary /ID# 211838

Manchester, , M13 9WL