A Study to Evaluate the Safety and Efficacy of Upadacitinib in Participants With Giant Cell Arteritis

Study Purpose

This study consists of two periods. The objective of Period 1 is to evaluate the efficacy of upadacitinib in combination with a 26-week corticosteroid (CS) taper regimen compared to placebo in combination with a 52-week CS taper regimen, as measured by the proportion of participants in sustained remission at Week 52, and to assess the safety and tolerability of upadacitinib in participants with giant cell arteritis (GCA). The objective of period 2 is to evaluate the safety and efficacy of continuing versus withdrawing upadacitinib in maintaining remission in participants who achieved remission in Period 1.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 50 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Diagnosis of giant cell arteritis (GCA) according to the following criteria: - History of erythrocyte sedimentation rate (ESR) >= 50 mm/hour or high sensitivity C-reactive protein (hsCRP)/CRP >=1.0 mg/dL.
  • - Presence of at least one of the following: Unequivocal cranial symptoms of GCA or Unequivocal symptoms of polymyalgia rheumatica (PMR) - Presence of at least one of the following: Temporal artery biopsy revealing features of GCA or evidence of large vessel vasculitis by angiography or cross-sectional imaging such as ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) or positron emission tomography (PET).
  • - Active GCA, either new onset or relapsing, within 6 weeks of Baseline.
  • - Participants must have received treatment with >=40 mg prednisone (or equivalent) at any time prior to Baseline and be receiving prednisone (or equivalent) >= 20 mg once daily (QD) at Baseline.
  • - Participants must have GCA that, in the opinion of the investigator, is clinically stable to allow the participant to safely initiate the protocol-defined corticosteroid (CS) taper regimen.
  • - Females must either be postmenopausal or permanently surgically sterile or, practicing at least 1 specified method of birth control through the study.

Exclusion Criteria:

  • - Prior exposure to any Janus Kinase (JAK) inhibitor.
  • - Treatment with an interleukin-6 (IL-6) inhibitor within 4 weeks of study start, or prior treatment with an IL-6 inhibitor and experienced a disease flare during treatment.
  • - Use of any of the following systemic immunosuppressant treatments within the specified timeframe prior to study start: - Anakinra within 1 week of study start.
  • - Methotrexate, hydroxychloroquine, cyclosporine, azathioprine, or mycophenolate within 4 weeks of study start.
  • - Oral corticosteroid (CS) for conditions other than GCA within 4 week of study start, or intravenous CS within 4 weeks of study start.
  • - Greater than or equal to 8 weeks for leflunomide if no elimination procedure was followed, or adhere to an elimination procedure.
  • - Cell-depleting agents or alkylating agents including cyclophosphamide within 6 months of study start.
  • - Current or past history of infection including herpes zoster or herpes simplex, HIV, active Tuberculosis, active or chronic recurring infection, active hepatitis B or C.
  • - Female who is pregnant, breastfeeding, or considering pregnancy during the study.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03725202
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

AbbVie
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

AbbVie Inc.
Principal Investigator Affiliation AbbVie
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Australia, Austria, Belgium, Canada, Czechia, Denmark, France, Germany, Greece, Hungary, Italy, Japan, Netherlands, New Zealand, Norway, Portugal, Romania, Russian Federation, Spain, Sweden, Switzerland, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Giant Cell Arteritis (GCA)
Study Website: View Trial Website
Arms & Interventions

Arms

Experimental: Arm A

Upadacitinib dose A administered daily + 26-week CS taper regimen

Experimental: Arm B

Upadacitinib dose B administered daily + 26-week CS taper regimen

Placebo Comparator: Arm C

Placebo administered daily + 52-week CS taper regimen

Interventions

Drug: - Upadacitinib

It will be administered orally.

Drug: - Corticosteroid (CS)

It will be administered orally.

Other: - Placebo

It will be administered orally.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Rheum Assoc of North Alabama /ID# 168668, Huntsville, Alabama

Status

Completed

Address

Rheum Assoc of North Alabama /ID# 168668

Huntsville, Alabama, 35801

Glendale, Arizona

Status

Recruiting

Address

Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 204702

Glendale, Arizona, 85306-9802

Long Beach, California

Status

Recruiting

Address

VA Long Beach Healthcare System /ID# 203833

Long Beach, California, 90822

Robin K. Dore MD, Inc /ID# 201950, Tustin, California

Status

Recruiting

Address

Robin K. Dore MD, Inc /ID# 201950

Tustin, California, 92780

Denver Arthritis Clinic /ID# 171552, Denver, Colorado

Status

Recruiting

Address

Denver Arthritis Clinic /ID# 171552

Denver, Colorado, 80230

Danbury, Connecticut

Status

Recruiting

Address

Western Connecticut Health Network- Germantown Rd /ID# 205071

Danbury, Connecticut, 06810-5038

Boca Raton, Florida

Status

Recruiting

Address

Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 169040

Boca Raton, Florida, 33486

Clearwater, Florida

Status

Completed

Address

Clinical Research of West Florida - Clearwater /ID# 201901

Clearwater, Florida, 33765

Lakes Research, LLC /ID# 210442, Miami, Florida

Status

Recruiting

Address

Lakes Research, LLC /ID# 210442

Miami, Florida, 33014

Miami, Florida

Status

Recruiting

Address

Ctr Arthritis & Rheumatic Dise /ID# 168667

Miami, Florida, 33173

Naples, Florida

Status

Recruiting

Address

Medallion Clinical Research Institute, LLC /ID# 168666

Naples, Florida, 34102

Omega Research Consultants /ID# 201903, Orlando, Florida

Status

Recruiting

Address

Omega Research Consultants /ID# 201903

Orlando, Florida, 32810

Plantation, Florida

Status

Completed

Address

IRIS Research and Development, LLC /ID# 169406

Plantation, Florida, 33324

Tampa, Florida

Status

Completed

Address

Clinical Research of West Florida - Tampa /ID# 201899

Tampa, Florida, 33606-1246

USF Health /ID# 207077, Tampa, Florida

Status

Recruiting

Address

USF Health /ID# 207077

Tampa, Florida, 33612-2201

Venice, Florida

Status

Recruiting

Address

Lovelace Scientific Resources /ID# 169041

Venice, Florida, 34292

Arthritis and Rheumatology /ID# 170295, Atlanta, Georgia

Status

Recruiting

Address

Arthritis and Rheumatology /ID# 170295

Atlanta, Georgia, 30342

Idaho Falls, Idaho

Status

Recruiting

Address

Institute of Arthritis Researc /ID# 168490

Idaho Falls, Idaho, 83404

Chicago, Illinois

Status

Not yet recruiting

Address

Rush University Medical Center /ID# 224581

Chicago, Illinois, 60612

Ochsner Clinic Foundation /ID# 200723, Baton Rouge, Louisiana

Status

Recruiting

Address

Ochsner Clinic Foundation /ID# 200723

Baton Rouge, Louisiana, 70836-6455

Monroe, Louisiana

Status

Recruiting

Address

The Arthritis & Diabetes Clinic, Inc. /ID# 171199

Monroe, Louisiana, 71203

New Orleans, Louisiana

Status

Recruiting

Address

Ochsner Clinic Foundation-New Orleans /ID# 171200

New Orleans, Louisiana, 70121

LSUHSC - Shreveport /ID# 202646, Shreveport, Louisiana

Status

Recruiting

Address

LSUHSC - Shreveport /ID# 202646

Shreveport, Louisiana, 71103

Portland, Maine

Status

Not yet recruiting

Address

Rheumatology Associates - Portland /ID# 225011

Portland, Maine, 04102-2643

Wheaton, Maryland

Status

Recruiting

Address

The Center for Rheumatology and Bone Research /ID# 168652

Wheaton, Maryland, 20902

Ann Arbor, Michigan

Status

Recruiting

Address

University of Michigan Hospitals /ID# 168645

Ann Arbor, Michigan, 48109-5008

Detroit, Michigan

Status

Recruiting

Address

Wayne State University Health Center /ID# 212755

Detroit, Michigan, 48201-2153

Henry Ford Medical Center /ID# 207456, Detroit, Michigan

Status

Recruiting

Address

Henry Ford Medical Center /ID# 207456

Detroit, Michigan, 48202-3046

Aa Mrc Llc /Id# 201854, Grand Blanc, Michigan

Status

Recruiting

Address

Aa Mrc Llc /Id# 201854

Grand Blanc, Michigan, 48439

West Michigan Rheumatology /ID# 168647, Grand Rapids, Michigan

Status

Completed

Address

West Michigan Rheumatology /ID# 168647

Grand Rapids, Michigan, 49546

Clinvest Research LLC /ID# 208182, Springfield, Missouri

Status

Recruiting

Address

Clinvest Research LLC /ID# 208182

Springfield, Missouri, 65810-2607

Lincoln, Nebraska

Status

Recruiting

Address

Physician Research Collaboration, LLC /ID# 168610

Lincoln, Nebraska, 68516

Somerset, New Jersey

Status

Recruiting

Address

University Clinical Research Center /ID# 202504

Somerset, New Jersey, 08873-3448

Univ Rochester Med Ctr /ID# 213527, Rochester, New York

Status

Recruiting

Address

Univ Rochester Med Ctr /ID# 213527

Rochester, New York, 14642

Marietta Memorial Hospital /ID# 210834, Marietta, Ohio

Status

Recruiting

Address

Marietta Memorial Hospital /ID# 210834

Marietta, Ohio, 45750-1635

STAT Research, Inc. /ID# 200436, Vandalia, Ohio

Status

Recruiting

Address

STAT Research, Inc. /ID# 200436

Vandalia, Ohio, 45377-9464

University of Pennsylvania /ID# 168655, Philadelphia, Pennsylvania

Status

Recruiting

Address

University of Pennsylvania /ID# 168655

Philadelphia, Pennsylvania, 19104-5502

Greenville, South Carolina

Status

Recruiting

Address

Piedmont Arthritis Clinic, PA /ID# 212431

Greenville, South Carolina, 29601

Summerville, South Carolina

Status

Recruiting

Address

Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 212761

Summerville, South Carolina, 29486-7887

West Tennessee Research Inst /ID# 209256, Jackson, Tennessee

Status

Recruiting

Address

West Tennessee Research Inst /ID# 209256

Jackson, Tennessee, 38305

Kingsport, Tennessee

Status

Recruiting

Address

Arthritis Associates of Kingsport /ID# 212756

Kingsport, Tennessee, 37660

Tekton Research, Inc. /ID# 201801, Austin, Texas

Status

Completed

Address

Tekton Research, Inc. /ID# 201801

Austin, Texas, 78745

Colleyville, Texas

Status

Recruiting

Address

Precision Comprehensive Clinical Research Solutions /ID# 201798

Colleyville, Texas, 76034

West Texas Clinical Research /ID# 204834, Lubbock, Texas

Status

Recruiting

Address

West Texas Clinical Research /ID# 204834

Lubbock, Texas, 79410-1198

Temple, Texas

Status

Completed

Address

Baylor Scott & White Health - Temple /ID# 213529

Temple, Texas, 76508

Burlington, Vermont

Status

Recruiting

Address

University of Vermont Medical Center /ID# 211179

Burlington, Vermont, 05401-1473

Carilion Clinic /ID# 212928, Roanoke, Virginia

Status

Recruiting

Address

Carilion Clinic /ID# 212928

Roanoke, Virginia, 24016

Kadlec Clinic Rheumatology /ID# 201618, Kennewick, Washington

Status

Completed

Address

Kadlec Clinic Rheumatology /ID# 201618

Kennewick, Washington, 99336

University of Washington /ID# 201619, Seattle, Washington

Status

Recruiting

Address

University of Washington /ID# 201619

Seattle, Washington, 98109

Franklin, Wisconsin

Status

Recruiting

Address

Aurora Rheumatology and Immunotherapy Center /ID# 201853

Franklin, Wisconsin, 53132

Medical College of Wisconsin /ID# 224557, Milwaukee, Wisconsin

Status

Not yet recruiting

Address

Medical College of Wisconsin /ID# 224557

Milwaukee, Wisconsin, 53226-3522

International Sites

Emeritus Research Sydney /ID# 201937, Botany, New South Wales, Australia

Status

Recruiting

Address

Emeritus Research Sydney /ID# 201937

Botany, New South Wales, 2019

The Prince of Wales Hospital /ID# 210995, Randwick, New South Wales, Australia

Status

Recruiting

Address

The Prince of Wales Hospital /ID# 210995

Randwick, New South Wales, 2031

Griffith University /ID# 223829, Southport, Queensland, Australia

Status

Recruiting

Address

Griffith University /ID# 223829

Southport, Queensland, 4222

The Queen Elizabeth Hospital /ID# 201939, Woodville, South Australia, Australia

Status

Recruiting

Address

The Queen Elizabeth Hospital /ID# 201939

Woodville, South Australia, 5011

Emeritus Research /ID# 201938, Camberwell, Victoria, Australia

Status

Recruiting

Address

Emeritus Research /ID# 201938

Camberwell, Victoria, 3124

Fiona Stanley Hospital /ID# 201941, Murdoch, Western Australia, Australia

Status

Recruiting

Address

Fiona Stanley Hospital /ID# 201941

Murdoch, Western Australia, 6150

Innsbruck, Tirol, Austria

Status

Recruiting

Address

Medizinische Universität Innsbruck /ID# 201786

Innsbruck, Tirol, 6020

Vienna, Wien, Austria

Status

Recruiting

Address

Rheuma-Zentrum Wien-Oberlaa GmbH /ID# 201781

Vienna, Wien, 1100

UZ Gent /ID# 202778, Gent, Oost-Vlaanderen, Belgium

Status

Recruiting

Address

UZ Gent /ID# 202778

Gent, Oost-Vlaanderen, 9000

UZ Gasthuisberg Leuven /ID# 202779, Leuven, Belgium

Status

Recruiting

Address

UZ Gasthuisberg Leuven /ID# 202779

Leuven, , 3000

UCL Mont Godinne /ID# 224334, Yvoir, Belgium

Status

Not yet recruiting

Address

UCL Mont Godinne /ID# 224334

Yvoir, , 5530

Edmonton, Alberta, Canada

Status

Recruiting

Address

University of Alberta - Division of Rheumatology /ID# 208629

Edmonton, Alberta, T6G 2B7

St. Joseph's Healthcare /ID# 204160, Hamilton, Ontario, Canada

Status

Recruiting

Address

St. Joseph's Healthcare /ID# 204160

Hamilton, Ontario, L8N 4A6

Rimouski, Quebec, Canada

Status

Not yet recruiting

Address

CISSSBSL -Hopital regional de Rimouski /ID# 224266

Rimouski, Quebec, G5L 5T1

Trois-rivières, Quebec, Canada

Status

Recruiting

Address

Ctr. de Recherche Musculo-Sque /ID# 201224

Trois-rivières, Quebec, G8Z 1Y2

Polmed Research Inc /ID# 201843, Saskatoon, Saskatchewan, Canada

Status

Recruiting

Address

Polmed Research Inc /ID# 201843

Saskatoon, Saskatchewan, S7K 0H6

Fakultni Nemocnice Olomouc /ID# 202041, Olomouc, Olomoucky Kraj, Czechia

Status

Recruiting

Address

Fakultni Nemocnice Olomouc /ID# 202041

Olomouc, Olomoucky Kraj, 779 00

Axon Clinical, s.r.o. /ID# 202468, Praha, Praha 5, Czechia

Status

Recruiting

Address

Axon Clinical, s.r.o. /ID# 202468

Praha, Praha 5, 150 00

Medical Plus, s.r.o. /ID# 200865, Uherské Hradište, Czechia

Status

Recruiting

Address

Medical Plus, s.r.o. /ID# 200865

Uherské Hradište, , 686 01

Aarhus Universitetshospital /ID# 171177, Aarhus C, Midtjylland, Denmark

Status

Recruiting

Address

Aarhus Universitetshospital /ID# 171177

Aarhus C, Midtjylland, 8000

Sydvestjysk Sygehus Esbjerg /ID# 200216, Esbjerg, Denmark

Status

Recruiting

Address

Sydvestjysk Sygehus Esbjerg /ID# 200216

Esbjerg, , 6700

CHU Dijon /ID# 225277, Dijon, Cote-d Or, France

Status

Not yet recruiting

Address

CHU Dijon /ID# 225277

Dijon, Cote-d Or, 21000

Lille CEDEX, Hauts-de-France, France

Status

Recruiting

Address

CHRU Lille - Hopital Claude Huriez /ID# 171543

Lille CEDEX, Hauts-de-France, 59045

Hopital de la Cavale Blanche /ID# 171549, Brest, France

Status

Recruiting

Address

Hopital de la Cavale Blanche /ID# 171549

Brest, , 29609

Caen Cedex 9, France

Status

Recruiting

Address

CHU de CAEN - Hopital de la Cote de Nacre /ID# 171539

Caen Cedex 9, , 14033

Hopital de la Croix Rousse /ID# 211184, Lyon, France

Status

Recruiting

Address

Hopital de la Croix Rousse /ID# 211184

Lyon, , 69004

Hopital Saint Joseph /ID# 171540, Marseille, France

Status

Recruiting

Address

Hopital Saint Joseph /ID# 171540

Marseille, , 13008

Nantes, France

Status

Recruiting

Address

CHU de Nantes, Hotel Dieu -HME /ID# 171544

Nantes, , 44093

Paris, France

Status

Recruiting

Address

CHU Paris-GH La Pitie Salpetriere /ID# 171542

Paris, , 75013

Paris, France

Status

Recruiting

Address

CHU Paris Centre - Hopital Coc /ID# 171545

Paris, , 75014

Toulouse Cedex 9, France

Status

Recruiting

Address

CHU de TOULOUSE - Hopital Purpan /ID# 171547

Toulouse Cedex 9, , 31059

Medius Klinik Kirchheim /ID# 200637, Kirchheim unter Teck, Baden-Wuerttemberg, Germany

Status

Recruiting

Address

Medius Klinik Kirchheim /ID# 200637

Kirchheim unter Teck, Baden-Wuerttemberg, 73230

Immanuel Krankenhaus Berlin /ID# 223855, Berlin-buch, Germany

Status

Recruiting

Address

Immanuel Krankenhaus Berlin /ID# 223855

Berlin-buch, , 13125

Burghausen, Germany

Status

Recruiting

Address

Medizinische Versorgungszentren Burghausen.Altoetting /ID# 208773

Burghausen, , 84489

Med Hochschule Hanover /ID# 200632, Hannover, Germany

Status

Recruiting

Address

Med Hochschule Hanover /ID# 200632

Hannover, , 30625

Tuebingen, Germany

Status

Recruiting

Address

Universitatsklinikum Tubingen /ID# 223854

Tuebingen, , 72076

Univ-Klinikum Wuerzburg /ID# 213340, Wuerzburg, Germany

Status

Recruiting

Address

Univ-Klinikum Wuerzburg /ID# 213340

Wuerzburg, , 97080

Athens, Greece

Status

Recruiting

Address

General Hospital of Athens Ippokratio /ID# 202181

Athens, , 11527

Genl Hosp Athens Gennimatas /ID# 210129, Athens, Greece

Status

Recruiting

Address

Genl Hosp Athens Gennimatas /ID# 210129

Athens, , 11527

Thessaloniki, Greece

Status

Recruiting

Address

424 General MILITARY Hospital /ID# 210973

Thessaloniki, , 56429

Budapest XI, Budapest, Hungary

Status

Recruiting

Address

Szent Imre Egyetemi Oktatokorhaz /ID# 201838

Budapest XI, Budapest, 1115

Budapest, Hungary

Status

Completed

Address

Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz /ID# 204018

Budapest, , 1023

Budapest, Hungary

Status

Recruiting

Address

Orszagos Reumatologiai es Fizi /ID# 211454

Budapest, , 1023

Debrecen, Hungary

Status

Recruiting

Address

Debreceni Egyetem Klinikai Kozpont /ID# 201526

Debrecen, , 4032

Modena, Emilia-Romagna, Italy

Status

Recruiting

Address

Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 200079

Modena, Emilia-Romagna, 41124

Ospedale di Bolzano /ID# 200081, Bolzano, Italy

Status

Recruiting

Address

Ospedale di Bolzano /ID# 200081

Bolzano, , 39100

Udine, Italy

Status

Recruiting

Address

Azienda Sanitaria Universitaria Friuli Centrale /ID# 200082

Udine, , 33100

Nagoya-shi, Aichi, Japan

Status

Recruiting

Address

Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 202946

Nagoya-shi, Aichi, 455-8530

Kagawa University Hospital /ID# 200171, Kita-gun, Kagawa, Japan

Status

Recruiting

Address

Kagawa University Hospital /ID# 200171

Kita-gun, Kagawa, 761-0793

Kawasaki-shi, Kanagawa, Japan

Status

Recruiting

Address

St. Marianna University School of Medicine Hospital /ID# 218692

Kawasaki-shi, Kanagawa, 216-8511

Kumamoto-shi, Kumamoto, Japan

Status

Recruiting

Address

Japanese Red Cross Kumamoto Hospital /ID# 203507

Kumamoto-shi, Kumamoto, 861-8520

Tohoku University Hospital /ID# 200172, Sendai-shi, Miyagi, Japan

Status

Recruiting

Address

Tohoku University Hospital /ID# 200172

Sendai-shi, Miyagi, 980-8574

Okayama University Hospital /ID# 203156, Okayama-shi, Okayama, Japan

Status

Recruiting

Address

Okayama University Hospital /ID# 203156

Okayama-shi, Okayama, 700-8558

Tomishiro Central Hospital /ID# 203897, Tomigusuku-shi, Okinawa, Japan

Status

Completed

Address

Tomishiro Central Hospital /ID# 203897

Tomigusuku-shi, Okinawa, 901-0243

Sakai City Medical Center /ID# 202643, Sakai-shi, Osaka, Japan

Status

Completed

Address

Sakai City Medical Center /ID# 202643

Sakai-shi, Osaka, 5938304

Shimotsuke-shi, Tochigi, Japan

Status

Completed

Address

Duplicate_Jichi Medical University Hosp /ID# 200169

Shimotsuke-shi, Tochigi, 329-0498

Chuo-ku, Tokyo, Japan

Status

Recruiting

Address

St.Luke's International Hospital /ID# 200170

Chuo-ku, Tokyo, 104-8560

Nijmegen, Gelderland, Netherlands

Status

Recruiting

Address

Radboud Universitair Medisch Centrum /ID# 212925

Nijmegen, Gelderland, 6525 GA

ZiekenhuisGroep Twente /ID# 200038, Almelo, Netherlands

Status

Recruiting

Address

ZiekenhuisGroep Twente /ID# 200038

Almelo, , 7609 PP

Groningen, Netherlands

Status

Recruiting

Address

Universitair Medisch Centrum Groningen /ID# 201715

Groningen, , 9713 GZ

Heerlen, Netherlands

Status

Not yet recruiting

Address

Atrium-Orbis Zuyderland Medisch Centrum /ID# 224551

Heerlen, , 6419 PC

Medisch Centrum Leeuwarden /ID# 201716, Leeuwarden, Netherlands

Status

Recruiting

Address

Medisch Centrum Leeuwarden /ID# 201716

Leeuwarden, , 8934 AD

Erasmus Medisch Centrum /ID# 201717, Rotterdam, Netherlands

Status

Recruiting

Address

Erasmus Medisch Centrum /ID# 201717

Rotterdam, , 3015 CE

Waikato Hospital /ID# 201944, Hamilton, Waikato, New Zealand

Status

Recruiting

Address

Waikato Hospital /ID# 201944

Hamilton, Waikato, 3204

Optimal Clinical Trials Ltd /ID# 201946, Auckland, New Zealand

Status

Recruiting

Address

Optimal Clinical Trials Ltd /ID# 201946

Auckland, , 1010

Middlemore Clinical Trials /ID# 201942, Auckland, New Zealand

Status

Recruiting

Address

Middlemore Clinical Trials /ID# 201942

Auckland, , 2025

CGM Research Trust /ID# 224061, Burwood Christchurch, New Zealand

Status

Recruiting

Address

CGM Research Trust /ID# 224061

Burwood Christchurch, , 8083

Porter Rheumatology Ltd /ID# 223830, Nelson, New Zealand

Status

Recruiting

Address

Porter Rheumatology Ltd /ID# 223830

Nelson, , 7010

Timaru, New Zealand

Status

Recruiting

Address

Timaru Medical Specialists Ltd /ID# 201943

Timaru, , 7910

Drammen Sykehus /ID# 201560, Drammen, Buskerud, Norway

Status

Recruiting

Address

Drammen Sykehus /ID# 201560

Drammen, Buskerud, 3004

Bergen, Hordaland, Norway

Status

Recruiting

Address

Haukeland universitetssjukehus /ID# 201602

Bergen, Hordaland, 5021

Rikshospitalet OUS HF /ID# 202004, Oslo, Norway

Status

Recruiting

Address

Rikshospitalet OUS HF /ID# 202004

Oslo, , 0450

Vila Nova De Gaia, Porto, Portugal

Status

Recruiting

Address

Centro Hospitalar Vila Nova Gaia/Espinho, EPE /ID# 208151

Vila Nova De Gaia, Porto, 4434-502

Guarda, Portugal

Status

Not yet recruiting

Address

Unidade Local de Saude da Guarda /ID# 224878

Guarda, , 6300-858

Lisboa, Portugal

Status

Recruiting

Address

Centro Hospitalar Lisboa Norte, EPE /ID# 203530

Lisboa, , 1649-035

Viana Do Castelo, Portugal

Status

Recruiting

Address

Unidade Local De Saude Alto Minho, EPE /ID# 205186

Viana Do Castelo, , 4901-858

Cabinet Dr. Avram S.R.L. /ID# 224336, Timisoara, Timis, Romania

Status

Not yet recruiting

Address

Cabinet Dr. Avram S.R.L. /ID# 224336

Timisoara, Timis, 300108

Colentina Clinical Hospital /ID# 204889, Bucharest, Romania

Status

Recruiting

Address

Colentina Clinical Hospital /ID# 204889

Bucharest, , 907206

Spitalul Clinic Sf. Maria /ID# 203809, Bucuresti, Romania

Status

Recruiting

Address

Spitalul Clinic Sf. Maria /ID# 203809

Bucuresti, , 011172

Clin County Hosp Cluj-Napoca /ID# 204887, Cluj, Romania

Status

Recruiting

Address

Clin County Hosp Cluj-Napoca /ID# 204887

Cluj, , 400006

Sibiu, Romania

Status

Not yet recruiting

Address

Spitalul Clinic Judetean de Ur /ID# 205151

Sibiu, , 550245

Kemerovo, Kemerovskaya Oblast, Russian Federation

Status

Recruiting

Address

Federal State Budgetary Educational Institution of Higher Education "Kemerovo St /ID# 203676

Kemerovo, Kemerovskaya Oblast, 650056

LLC Practical Medicine /ID# 224612, Moscow, Russian Federation

Status

Not yet recruiting

Address

LLC Practical Medicine /ID# 224612

Moscow, , 115405

Moscow, Russian Federation

Status

Recruiting

Address

Sechenov First Moscow Medical /ID# 203673

Moscow, , 119992

Moscow RRCI M.F. Vladimirski /ID# 221643, Moscow, Russian Federation

Status

Recruiting

Address

Moscow RRCI M.F. Vladimirski /ID# 221643

Moscow, , 129110

PMI Euromedservice /ID# 205345, Pushkin, Russian Federation

Status

Recruiting

Address

PMI Euromedservice /ID# 205345

Pushkin, , 196603

Sankt-Peterburg, Russian Federation

Status

Recruiting

Address

Clinical Rheumatologic Hospital No 25 /ID# 208950

Sankt-Peterburg, , 190068

A Coruña, A Coruna, Spain

Status

Recruiting

Address

Hospital Universitario A Coruña - CHUAC /ID# 224731

A Coruña, A Coruna, 15006

Santander, Cantabria, Spain

Status

Recruiting

Address

Hospital Unversitario Marques de Valdecilla /ID# 201604

Santander, Cantabria, 39008

Hospital Meixoeiro (CHUVI) /ID# 212084, Vigo, Pontevedra, Spain

Status

Recruiting

Address

Hospital Meixoeiro (CHUVI) /ID# 212084

Vigo, Pontevedra, 36213

la Cuesta, Santa Cruz De Tenerife, Spain

Status

Recruiting

Address

Hospital Universitario Canarias /ID# 224928

la Cuesta, Santa Cruz De Tenerife, 38320

Hospital Clinic de Barcelona /ID# 201878, Barcelona, Spain

Status

Recruiting

Address

Hospital Clinic de Barcelona /ID# 201878

Barcelona, , 08036

Bilbao, Spain

Status

Not yet recruiting

Address

Hospital Universitario Basurto /ID# 224730

Bilbao, , 48013

Granada, Spain

Status

Recruiting

Address

Hospital Universitario Virgen de las Nieves /ID# 224726

Granada, , 18014

Madrid, Spain

Status

Recruiting

Address

Hospital General Universitario Gregorio Maranon /ID# 201326

Madrid, , 28007

Madrid, Spain

Status

Recruiting

Address

Hospital Clinico Universitario San Carlos /ID# 204871

Madrid, , 28040

Skanes Universitetssjukhus /ID# 171407, Malmö, Skane Lan, Sweden

Status

Recruiting

Address

Skanes Universitetssjukhus /ID# 171407

Malmö, Skane Lan, 214 28

Sahlgrenska US Gbg /ID# 171405, Göteborg, Vastra Gotalands Lan, Sweden

Status

Recruiting

Address

Sahlgrenska US Gbg /ID# 171405

Göteborg, Vastra Gotalands Lan, 413 46

Karolinska Univ Sjukhuset /ID# 204945, Solna, Sweden

Status

Recruiting

Address

Karolinska Univ Sjukhuset /ID# 204945

Solna, , 17176

Danderyds sjukhus /ID# 171404, Stockholm, Sweden

Status

Recruiting

Address

Danderyds sjukhus /ID# 171404

Stockholm, , 182 88

Uppsala University Hospital /ID# 171403, Uppsala, Sweden

Status

Not yet recruiting

Address

Uppsala University Hospital /ID# 171403

Uppsala, , 75185

Vastmanlands Sjukhus /ID# 171429, Vasteras, Sweden

Status

Recruiting

Address

Vastmanlands Sjukhus /ID# 171429

Vasteras, , 352 34

Kantonsspital St. Gallen /ID# 201134, St. Gallen, Sankt Gallen, Switzerland

Status

Recruiting

Address

Kantonsspital St. Gallen /ID# 201134

St. Gallen, Sankt Gallen, 9007

University Hospital of Basel /ID# 201767, Basel, Switzerland

Status

Recruiting

Address

University Hospital of Basel /ID# 201767

Basel, , 4031

Bern, Switzerland

Status

Recruiting

Address

Inselspital, Universitaetsklinik /ID# 201364

Bern, , 3010

Fribourg, Switzerland

Status

Recruiting

Address

HFR Fribourg - Hopital Canton /ID# 201114

Fribourg, , 1708

RD&E Hospital /ID# 202834, Exeter, Devon, United Kingdom

Status

Recruiting

Address

RD&E Hospital /ID# 202834

Exeter, Devon, EX2 5DW

Whipps Cross Univ Hospital /ID# 210511, London, London, City Of, United Kingdom

Status

Recruiting

Address

Whipps Cross Univ Hospital /ID# 210511

London, London, City Of, E11 1NR

UH Coventry & Warwickshire /ID# 202838, Coventry, United Kingdom

Status

Recruiting

Address

UH Coventry & Warwickshire /ID# 202838

Coventry, , CV2 2DX

Chapel Allerton Hospital /ID# 202837, Leeds, United Kingdom

Status

Not yet recruiting

Address

Chapel Allerton Hospital /ID# 202837

Leeds, , LS7 4SA

Luton, United Kingdom

Status

Not yet recruiting

Address

Luton & Dunstable University Hospital /ID# 224020

Luton, , LU4 0DZ

Poole, United Kingdom

Status

Recruiting

Address

Poole Hospital NHS Foundation /ID# 202836

Poole, , BH15 2JB

Southend Hospital /ID# 202839, Southend, United Kingdom

Status

Recruiting

Address

Southend Hospital /ID# 202839

Southend, , SS0 0RY

Torquay, United Kingdom

Status

Not yet recruiting

Address

Torbay and South Devon Nhs Foundation Trust /Id# 224689

Torquay, , TQ2 7AA