Evaluation of the Long Term Safety, Tolerability and Efficacy of Two Dosing Regimens of Olokizumab (OKZ), in Subjects With Rheumatoid Arthritis (RA) Who Previously Completed 24 Weeks of Blinded Treatment in One of the Core Studies - CREDO 1, 2 or 3.
Study Purpose
The purpose of the study is to evaluate how safe, how effective and how well tolerated, the study drug Olokizumab is, in the long-term, in patients with Rheumatoid Arthritis (RA) who have previously taken part in and completed 24 weeks of blinded treatment in one of the core studies
- - CREDO 1, 2 or 3.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
Subjects may be enrolled in the study only if they meet all of the following criteria: 1. Subject must be willing and able to sign informed consent. 2. Subject must have completed the 24-week double-blind Treatment Period in 1 of the 3 core studies (CL04041022, CL04041023, or CL04041025). 3. Subject must have maintained their stable dose (and route) of MTX 15 to 25 mg/week (or ≥10 mg/week if there is documented intolerance to higher doses) during the core study and plan to maintain the same dose and route of administration for additional 12 weeks. 4. Subjects must be willing to take folic acid or equivalent throughout the study.Exclusion Criteria:
1. Subject with any medically important condition in the core study (e.g., clinically significant laboratory values, frequent AEs or SAEs, infection SAEs, and/or other concurrent severe and/or uncontrolled medical condition) which would make this subject unsuitable for inclusion in the open-label extension (OLE) study in the Investigator's judgement. 2. Subject has evidence of active tuberculosis (TB) 3. Subject has planned surgery during the first 12 weeks of the OLE. 4. Female subjects who are pregnant or who are planning to become pregnant during the study or within 6 months of the last dose of study drug. 5. Female subjects of childbearing who are not willing to use a highly effective method of contraception during the study OR Male subjects with partners of childbearing potential not willing to use a highly effective method of contraception during the study. 6. Subject is unwilling or unable to follow the procedures outlined in the protocol. 7. Other medical or psychiatric conditions, or lab abnormalities that may increase the potential risk associated with study participation and administration of investigational medicinal products (IMPs), or that may affect study results interpretation and, as per Investigator's judgement, make the subject ineligible. The following restrictions may affect a subject's ability to participate in this study:- - Availability to attend visits according to the protocol within the allowed window period.
- - Ability to perform self-administration of study drug and availability of caregiver to administer study drug.
- - Concomitant medication restrictions as described in the Informed Consent Form and protocol (water and concomitant medications are permitted) for at least 9 hours prior to all study visits 8.
- - Subjects may be enrolled in the OLE study if they fulfill all 3 of the following criteria prior to the first dose of study treatment: 1.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT03120949 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
R-Pharm |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Mikhail Samsonov |
| Principal Investigator Affiliation | Chief Medical Officer, R-Pharm |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry, Other |
| Overall Status | Recruiting |
| Countries | Argentina, Brazil, Bulgaria, Colombia, Czechia, Estonia, Germany, Hungary, Korea, Republic of, Latvia, Lithuania, Mexico, Poland, Romania, Russian Federation, Taiwan, United Kingdom, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Rheumatoid Arthritis |
The goal of this Phase III study is to evaluate the long-term safety, tolerability, and efficacy of OKZ in subjects with moderately to severely active RA who previously completed 24 weeks of double-blind treatment with OKZ in the core studies. OKZ is expected to reduce the disease activity and induce an improvement in physical function. The study is expected to provide long-term safety information in a large group of subjects treated with OKZ for up to 106 weeks.
Arms
Experimental: Treatment Arm 1
Olokizumab 64 mg SC q4w + Methotrexate (oral)
Experimental: Treatment Arm 2
Olokizumab 64 mg SC q2w + Methotrexate (oral)
Interventions
Drug: - Olokizumab 64 mg SC q4w
Treatment Arm 1, Experimental, Olokizumab 64 mg Subcutaneous q4w + Methotrexate (oral)
Drug: - Olokizumab 64 mg SC q2w
Treatment Arm 2, Experimental, Olokizumab 64 mg Subcutaneous q2w + Methotrexate (oral)
Drug: - Methotrexate
Treatment Arm 1, Experimental, Olokizumab 64 mg Subcutaneous q4w + Methotrexate (oral); Treatment Arm 2, Experimental, Olokizumab 64 mg Subcutaneous q2w + Methotrexate (oral)
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Withdrawn
Address
Rheumatology Associates Of North Alabama- RANA PC
Huntsville, Alabama, 35801
Status
Recruiting
Address
Arizona Arthritis & Rheumatology Research, PLLC
Glendale, Arizona, 85306
Status
Recruiting
Address
Arizona Arthritis & Rheumatology Associates, P.C.
Mesa, Arizona, 85202
Status
Withdrawn
Address
Arizona Arthritis & Rheumatology Research, PLLC
Phoenix, Arizona, 85032-9384
Status
Recruiting
Address
Arizona Arthritis & Rheumatology Associates, P.C.
Phoenix, Arizona, 85032
Status
Withdrawn
Address
Radiant Research, Inc.
Scottsdale, Arizona, 85251
Status
Recruiting
Address
Arizona Arthritis & Rheumatology Research, PLLC
Sun City, Arizona, 85351
Status
Recruiting
Address
CHI St. Vincent Hot Springs
Hot Springs, Arkansas, 71913
Status
Recruiting
Address
CHI St. Vincent Hot Springs
Hot Springs, Arkansas, 71913
Status
Recruiting
Address
Little Rock Diagnostic Clinic, PA
Little Rock, Arkansas, 72205
Status
Recruiting
Address
Medvin Clinical Research
Covina, California, 91722
Status
Recruiting
Address
TriWest Research Associates, LLC
El Cajon, California, 92020-4124
Status
Withdrawn
Address
Aviva Research
Escondido, California, 92025
Status
Withdrawn
Address
Saint Jude Heritage Medical Grp
Fullerton, California, 92835
Status
Recruiting
Address
MD Med Corp.
Hemet, California, 92543
Status
Recruiting
Address
Advanced Medical Research, LLC
La Palma, California, 90623
Status
Recruiting
Address
Valerius Medical Group
Los Alamitos, California, 90720-5403
Status
Recruiting
Address
Stanford University School of Medicine
Palo Alto, California, 94304
Status
Recruiting
Address
Riverside Medical Clinic
Riverside, California, 92506
Status
Recruiting
Address
Rheumatology Center of San Diego
San Diego, California, 92122
Status
Recruiting
Address
East Bay Rheumatology Medical Group, Inc.
San Leandro, California, 94578
Status
Recruiting
Address
Orrin M Troum and Medical Associates
Santa Monica, California, 90404
Status
Recruiting
Address
Inland Rheumatology Clinical Trials, Inc.
Upland, California, 91786
Status
Recruiting
Address
Nazanin Firooz, MD Inc.
West Hills, California, 91307
Status
Recruiting
Address
Medvin Clinical Research
Whittier, California, 90602
Status
Recruiting
Address
Denver Arthritis Clinic
Denver, Colorado, 80230
Status
Withdrawn
Address
Arthritis & Osteoporosis Center PC
Hamden, Connecticut, 06518
Status
Recruiting
Address
New England Research Associates LLC
Trumbull, Connecticut, 06611
Status
Recruiting
Address
Delaware Arthritis
Delaware City, Delaware, 19958
Status
Recruiting
Address
Javed Rheumatology Associates
Newark, Delaware, 19713
Status
Recruiting
Address
RASF - Clinical Research Center
Boca Raton, Florida, 33486
Status
Recruiting
Address
Reliable Clinical Research, LLC
Hialeah, Florida, 33012
Status
Recruiting
Address
Pharmax Research Clinic
Miami, Florida, 33126
Status
Recruiting
Address
Suncoast Research Group, LLC
Miami, Florida, 33135
Status
Recruiting
Address
Suncoast Research Group, LLC
Miami, Florida, 33135
Status
Recruiting
Address
Medical Research Center of Miami
Miami, Florida, 33144
Status
Recruiting
Address
Suncoast Clinical Research Inc.
New Port Richey, Florida, 34652
Status
Withdrawn
Address
Arthritis & Osteoporosis Treatment Center, P.A.
Orange Park, Florida, 32073
Status
Recruiting
Address
Omega Research Consultants
Orlando, Florida, 32804
Status
Recruiting
Address
Omega Research Consultants
Orlando, Florida, 32810
Status
Recruiting
Address
Arthritis Center
Palm Harbor, Florida, 34684
Status
Recruiting
Address
Arthritis Research of Florida, INC
Palm Harbor, Florida, 34684
Status
Recruiting
Address
Family Clinical Trials, LLC.
Pembroke Pines, Florida, 33026
Status
Recruiting
Address
McIlwain Medical Group, PA
Tampa, Florida, 33614
Status
Recruiting
Address
Lovelace Scientific Resources, Inc.
Venice, Florida, 34292
Status
Recruiting
Address
Arthritis Center of North Georgia
Gainesville, Georgia, 30501
Status
Recruiting
Address
Marietta Rheumatology Associates, PC
Marietta, Georgia, 30060
Status
Recruiting
Address
Institute of Arthritis Research
Idaho Falls, Idaho, 83404
Status
Recruiting
Address
Advanced Clinical Research
Meridian, Idaho, 83642
Status
Recruiting
Address
Rush University Medical Center
Chicago, Illinois, 60612
Status
Recruiting
Address
University of Kansas Hospital
Kansas City, Kansas, 66160
Status
Withdrawn
Address
Via Christi Research, a division of Via Christi Hospitals Wichita, Inc.
Wichita, Kansas, 67208
Status
Recruiting
Address
Graves Gilbert Clinic
Bowling Green, Kentucky, 42101
Status
Withdrawn
Address
Research Integrity, LLC
Owensboro, Kentucky, 42303
Status
Recruiting
Address
The Arthritis & Diabetes Clinic, Inc.
Monroe, Louisiana, 71203
Status
Recruiting
Address
Klein and Associates, M.D., P.A.
Cumberland, Maryland, 21502
Status
Withdrawn
Address
Arthritis Treatment Center
Frederick, Maryland, 21702
Status
Recruiting
Address
Klein and Associates, M.D., P.A.
Hagerstown, Maryland, 21740
Status
Recruiting
Address
The Center for Rheumatology and Bone Research
Wheaton, Maryland, 20902
Status
Recruiting
Address
Clinical Pharmacology Study Group
Worcester, Massachusetts, 01605
Status
Recruiting
Address
AA MRC LLC Ahmed Arif Medical Research Center
Grand Blanc, Michigan, 48439
Status
Recruiting
Address
North MS Medical Clinics, Inc.
Tupelo, Mississippi, 38801
Status
Withdrawn
Address
St. Louis Center for Clinical Research
Saint Louis, Missouri, 63128
Status
Recruiting
Address
Glacier View Research Institute-Rheumatology
Kalispell, Montana, 59901
Status
Recruiting
Address
Physician Research Collaboration
Lincoln, Nebraska, 68516
Status
Withdrawn
Address
Westroads Clinical Research
Omaha, Nebraska, 68114
Status
Recruiting
Address
Allied Clinical Research
Reno, Nevada, 89519
Status
Recruiting
Address
Arthritis & Osteoporosis Associates, PA
Freehold, New Jersey, 07728
Status
Recruiting
Address
Lovelace Scientific Resources, Inc.
Albuquerque, New Mexico, 87114
Status
Withdrawn
Address
The Center for Rheumatology, LLP
Albany, New York, 12203
Status
Recruiting
Address
Weill Cornell Physicians at Brooklyn Heights
Brooklyn, New York, 11201
Status
Recruiting
Address
Medication Management, LLC
Greensboro, North Carolina, 27408
Status
Recruiting
Address
Medication Management, LLC
Greensboro, North Carolina, 27410
Status
Recruiting
Address
Cape Fear Arthritis Care
Leland, North Carolina, 28451
Status
Recruiting
Address
Carolina Arthritis Associates
Wilmington, North Carolina, 28401
Status
Recruiting
Address
Trinity Medical Group
Minot, North Dakota, 58701
Status
Recruiting
Address
Cincinnati Rheumatic Disease Study Group
Cincinnati, Ohio, 45242
Status
Recruiting
Address
STAT Research, Inc.
Dayton, Ohio, 45417
Status
Recruiting
Address
Clinical Research Source, Inc.
Toledo, Ohio, 43606
Status
Recruiting
Address
Health Research of Oklahoma, PLLC
Oklahoma City, Oklahoma, 73103
Status
Recruiting
Address
Lynn Health Science Institute
Oklahoma City, Oklahoma, 73112
Status
Recruiting
Address
Altoona Center for Clinical Research, P.C.
Duncansville, Pennsylvania, 16635
Status
Recruiting
Address
Arthritis Group
Philadelphia, Pennsylvania, 19152
Status
Recruiting
Address
Low Country Rheumatology, PA
North Charleston, South Carolina, 29406
Status
Recruiting
Address
Center for Inflammatory Disease
Nashville, Tennessee, 37203-2032
Status
Recruiting
Address
Amarillo Center for Clinical Research
Amarillo, Texas, 79124
Status
Recruiting
Address
Austin Regional Clinic, P.A.
Austin, Texas, 78731
Status
Recruiting
Address
Accurate Clinical Management., LLC
Baytown, Texas, 77521
Status
Recruiting
Address
Diagnostic Group of Southeast Texas
Beaumont, Texas, 77701
Status
Recruiting
Address
Pioneer Research Solutions, Inc.
Beaumont, Texas, 77702
Status
Recruiting
Address
Pioneer Research Solutions, Inc.
Cypress, Texas, 77429
Status
Recruiting
Address
Precision Comprehensive Clinical Research Solutions
Grapevine, Texas, 76051
Status
Withdrawn
Address
Accurate Clinical Management LLC
Houston, Texas, 77004
Status
Recruiting
Address
Rheumatic Disease Clinical Research Center, LLC
Houston, Texas, 77004
Status
Recruiting
Address
Accurate Clinical Research, Inc.
Houston, Texas, 77034
Status
Recruiting
Address
Accurate Clinical Research, Inc.
Houston, Texas, 77034
Status
Recruiting
Address
Rheumatology Clinic of Houston, P.A.
Houston, Texas, 77065
Status
Recruiting
Address
Houston Institute For Clinical Research
Houston, Texas, 77074
Status
Recruiting
Address
Medical Center Research, LLC
Houston, Texas, 77089
Status
Recruiting
Address
Arthritis & Osteoporosis Associates LLP
Lubbock, Texas, 79410
Status
Withdrawn
Address
Arthritis & Osteoporosis Associates LLP
Lubbock, Texas, 79424
Status
Recruiting
Address
Accurate Clinical Research, Inc.
Nassau Bay, Texas, 77058
Status
Recruiting
Address
Dr. Alex De Jesus Rheumatology, P.A.
San Antonio, Texas, 78229
Status
Recruiting
Address
Advanced Rheumatology of Houston
The Woodlands, Texas, 77382
Status
Recruiting
Address
DM Clinical Research
Tomball, Texas, 77375
Status
Withdrawn
Address
The Center For Arthritis and Rheumatic Diseases
Chesapeake, Virginia, 23320
Status
Recruiting
Address
Arthritis Northwest, PLLC
Spokane, Washington, 99204
Status
Recruiting
Address
West Virginia Research Institute
South Charleston, West Virginia, 25309
International Sites
Status
Not yet recruiting
Address
Hospital Italiano Regional del Sur
BahÃa Blanca, Buenos Aires, B8001HXM
Status
Active, not recruiting
Address
Centro de Investigaciones Medicas Mar del Plata
Mar del Plata, Buenos Aires, B7600FYK
Status
Recruiting
Address
Instituto Medico CER
Quilmes, Buenos Aires, B1878DVB
Status
Recruiting
Address
Instituto de Investigaciones Clinicas Quilmes
Quilmes, Buenos Aires, B1878GEG
Status
Withdrawn
Address
IARI (Instituto de Asistencia Reumatologica Integral)
San Fernando, Buenos Aires, 1646
Status
Recruiting
Address
Instituto Medico DAMIC
Córdoba, Cordoba, X5003DCE
Status
Not yet recruiting
Address
Sanatorio Delta
Rosario, Santa Fe, S2000BIF
Status
Recruiting
Address
Clinica de Higado y Aparato Digestivo
Rosario, Santa Fe, S2000
Status
Not yet recruiting
Address
Sanatorio San Martin
Venado Tuerto, Santa Fe, S2600KUE
Status
Recruiting
Address
Centro Medico Privado de Reumatologia
San Miguel de Tucuman, Tucuman, T4000AXL
Status
Recruiting
Address
Instituto de Investigaciones Clinicas-Mar del Plata
Buenos Aires, , B7600FZ
Status
Recruiting
Address
Organizacion Medica de Investigacion (OMI)
Ciudad Autonoma Buenos Aires, , C1015ABO
Status
Not yet recruiting
Address
APRILLUS
Ciudad Autonoma Buenos aires, , C1046AAQ
Status
Not yet recruiting
Address
Centro de Investigacion en Enfermedades Reumaticas CIER
Ciudad Autonoma Buenos Aires, , C1055AAF
Status
Recruiting
Address
Instituto Centenario
Ciudad Autonoma Buenos Aires, , C1204AAD
Status
Not yet recruiting
Address
Hospital General de Agudos Dr. J. M. Ramos Mejia
Ciudad Autonoma Buenos Aires, , C1221ADC
Status
Recruiting
Address
Atencion Integral en Reumatologia (AIR)
Ciudad Autonoma Buenos Aires, , C1426AAL
Status
Not yet recruiting
Address
Consultora Integral de Salud S.R.L.
Cordoba, , 5004
Status
Recruiting
Address
Hospital Privado Centro Medico de Cordoba
Cordoba, , X5016KEH
Status
Not yet recruiting
Address
Instituto DAMIC Fundacion Rusculleda
Córdoba, , X5003DCE
Status
Recruiting
Address
Centro Polivalente de Asistencia e Inv. Clinica CER
San Juan, , J5402DIL
Status
Recruiting
Address
Centro de Investigaciones Reumatológicas
Tucuman, , T4000BRD
Status
Recruiting
Address
HUWC - UFC - Hospital Universitário Walter CantÃdio - Universidade Federal do Ceará
Fortaleza, Ceará, 60430-370
Status
Recruiting
Address
CEDOES - Diagnóstico e Pesquisa
Vitória, EspÃrito Santo, 29055-450
Status
Recruiting
Address
CIP - Centro Internacional de Pesquisa
Goiânia, Goiás, 74110-120
Status
Recruiting
Address
CMiP - Centro Mineiro de Pesquisa
Juiz de Fora, Minas Gerais, 36010-570
Status
Recruiting
Address
CETI - Centro de Estudos em Terapias Inovadoras Ltda.
Curitiba, Paraná, 80030-110
Status
Recruiting
Address
Clinilive - ClÃnica do Idoso e Pesquisa ClÃnica
Maringá, Paraná, 87.015-180
Status
Not yet recruiting
Address
Hospital Bruno Born
Lajeado, Rio Grande Do Sul, 95900-000
Status
Not yet recruiting
Address
Hospital São Vicente de Paulo
Passo Fundo, Rio Grande Do Sul, 99010-080
Status
Recruiting
Address
LMK Serviços Médicos S/S Ltda
Pôrto Alegre, Rio Grande Do Sul, 90480-000
Status
Not yet recruiting
Address
ClÃnica de Neoplasias Litoral Ltda.
ItajaÃ, Santa Catarina, 88301-220
Status
Recruiting
Address
Faculdade de Medicina do ABC
Santo André, Sao Paulo, 09060-650
Site Contact
Sônia Maria Alvarenga Anti Loduca Lima
Status
Recruiting
Address
Centro Multidisciplinar de Estudos ClÃnicos - CEMEC
Santo André, Sao Paulo, 09190-510
Status
Withdrawn
Address
HUCFF-UFRJ - Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro
Rio de Janeiro, , 21941-913
Status
Recruiting
Address
CCBR Brasil Centro de Pesquisas e Análises ClÃnicas Ltda.
Rio de Janeiro, , 22271-100
Status
Recruiting
Address
CPCLIN - Centro de Pesquisas ClÃnicas Ltda.
São Paulo, , 01244-030
Status
Recruiting
Address
Hospital Abreu Sodré - AACD
São Paulo, , 04023-000
Status
Recruiting
Address
DCC 'Sv. Pantaleymon' OOD
Pleven, , 5800
Status
Recruiting
Address
UMHAT "Kaspela", EOOD
Plovdiv, , 4002
Status
Not yet recruiting
Address
MHAT-Plovdiv AD
Plovdiv, , 4003
Status
Recruiting
Address
MHAT - Ruse, AD
Ruse, , 7002
Status
Recruiting
Address
Medizinski Zentar-1-Sevlievo EOOD
Sevlievo, , 5400
Status
Recruiting
Address
Medizinski Zentar-1-Sevlievo EOOD
Sevlievo, , 5400
Status
Recruiting
Address
MHAT - Shumen, AD
Shumen, , 9700
Status
Recruiting
Address
NMTH "Tsar Boris III"
Sofia, , 1233
Status
Recruiting
Address
MHAT "Lyulin", EAD
Sofia, , 1336
Status
Recruiting
Address
Medical Center "Excelsior", OOD
Sofia, , 1407
Status
Recruiting
Address
UMHAT "Sv. Ivan Rilski", EAD
Sofia, , 1431
Status
Recruiting
Address
MC "Synexus - Sofia", EOOD
Sofia, , 1784
Status
Recruiting
Address
MDHAT 'Dr. Stefan Cherkezov', AD
Veliko Tarnovo, , 5000
Status
Recruiting
Address
Centro de Reumatologia y Ortopedia SAS
Barranquilla, , 080001
Status
Not yet recruiting
Address
Fundacion Instituto de Reumatologia Fernando Chalem
Bogotá, , 00000
Status
Not yet recruiting
Address
Centro de Investigacion en Reumatologia y Especialidades Medicas SAS. CIREEM
Bogotá, ,
Status
Not yet recruiting
Address
Medicity S.A.S.
Bucaramanga, , 680001
Status
Not yet recruiting
Address
Clinica de Artritis Temprana S.A.
Cali, , 76001
Status
Recruiting
Address
Hospital Pablo Tobón Uribe
MedellÃn, , 050034
Status
Recruiting
Address
IMEDICA s.r.o.
Brno, , 602 00
Status
Recruiting
Address
Revmatologie s.r.o.
Brno, , 638 00
Status
Recruiting
Address
Revmatologicka ambulance
Jihlava, , 586 01
Status
Recruiting
Address
Revmatologicka a interni ambulance
Kladno, , 272 01
Status
Withdrawn
Address
Revmatologie MUDr. Klara Sirova s.r.o.
Ostrava - Moravska Ostrava, , 702 00
Status
Recruiting
Address
ARTROSCAN s.r.o.
Ostrava - Trebovice, , 722 00
Status
Recruiting
Address
Vesalion s.r.o.
Ostrava, , 70200
Status
Recruiting
Address
CLINTRIAL s.r.o.
Praha 10, , 100 00
Status
Recruiting
Address
Revmatologicka ambulance
Praha 4 Nusle, , 140 00
Status
Recruiting
Address
Nuselska poliklinika
Praha 4, , 14000
Status
Recruiting
Address
Fakultni nemocnice v Motole
Praha 5, , 150 06
Status
Recruiting
Address
Affidea Praha s.r.o.
Praha, , 148 00
Status
Recruiting
Address
MEDICAL PLUS, s.r.o.
Uherske Hradiste, , 686 01
Status
Recruiting
Address
PV - MEDICAL, s.r.o.
Zlin, , 760 01
Status
Recruiting
Address
East Tallinn Central Hospital
Tallinn, , 11312
Status
Recruiting
Address
Medita Kliinik OÜ
Tartu, , 50107
Status
Not yet recruiting
Address
Kerckhoff-Klinik gGmbH
Bad Nauheim, Hessen, 61231
Status
Not yet recruiting
Address
CIRI - Centrum für Innovative Diagnostik und Therapie GmbH
Frankfurt, Hessen, 60528
Status
Withdrawn
Address
Rheumazentrum Prof. Dr. G. Neeck
Bad Doberan, Mecklenburg Vorpommern, 18209
Status
Recruiting
Address
Rheumapraxis Dr. med. Reiner Kurthen
Aachen, Nordrhein Westfalen, 52064
Status
Recruiting
Address
Studienambulanz Dr. Wassenberg
Ratingen, Nordrhein Westfalen, 40878
Status
Recruiting
Address
SMO.MD GmbH
Magdeburg, Sachsen Anhalt, 39120
Status
Recruiting
Address
Charite Universitaetsmedizin Berlin
Berlin, , 10117
Status
Recruiting
Address
Klinische Forschung Berlin-Mitte GmbH
Berlin, , 10117
Status
Recruiting
Address
HRF Hamburger Rheuma Forschungszentrum
Hamburg, , 20095
Status
Recruiting
Address
Principal SMO Kft.
Baja, , 6500
Status
Recruiting
Address
DRC Gyogyszervizsgalo Kozpont Kft.
Balatonfüred, , 8230
Status
Recruiting
Address
Clinexpert Egeszsegugyi Szolg. Es Kft.
Budapest, , 1033
Status
Recruiting
Address
Obudai Egeszsegugyi Centrum Kft.
Budapest, , 1036
Status
Not yet recruiting
Address
Debreceni Egyetem Klinikai Kozpont
Debrecen, , H-4032
Status
Recruiting
Address
Kiskunhalasi Semmelweis Korhaz
Kiskunhalas, , 6400
Status
Recruiting
Address
MAV Korhaz es Rendelointezet
Szolnok, , 5000
Status
Recruiting
Address
DRC Szekesfehervar
Székesfehérvár, , 8000
Status
Recruiting
Address
Vital-Medicina Kft.
Veszprem, , 8200
Status
Recruiting
Address
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggi-do, 431-796
Status
Recruiting
Address
CHA Bundang Medical Center, CHA University
Seongnam-si, Gyeonggi-do, 13496
Status
Recruiting
Address
Ajou University Hospital
Suwon-si, Gyeonggi-do, 16499
Status
Withdrawn
Address
Chonbuk National University Hospital
Jeonju, Jeollabuk-do, 54907
Status
Recruiting
Address
Chungnam National University Hospital
Daejeon, , 35015
Status
Not yet recruiting
Address
Chungnam National University Hospital
Daejeon, , 35015
Status
Recruiting
Address
Eulji University Hospital
Daejeon, , 35233
Status
Recruiting
Address
Chonnam National University Hospital
Gwangju, , 61469
Status
Recruiting
Address
Jeju National University Hospital
Jeju, , 63241
Status
Recruiting
Address
Severance Hospital, Yonsei University
Seoul, , 03722
Status
Recruiting
Address
Hanyang University Seoul Hospital
Seoul, , 04763
Status
Recruiting
Address
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, , 06591
Status
Recruiting
Address
Dr.Saulite-Kandevica Private Practice
Liepaja, , LV-3401
Status
Recruiting
Address
GK Neiroklinika
Riga, , LV1024
Status
Recruiting
Address
Alytus Regional S. Kudirkos Hospital, Public Institution
Alytus, , 62114
Status
Recruiting
Address
Republican Kaunas Hospital, Public Institution
Kaunas, , 45130
Status
Recruiting
Address
Klaipeda University Hospital, Public Institution
Klaipeda, , 92288
Status
Recruiting
Address
Siauliai Republican Hospital, Public Institution
Siauliai, , 76231
Status
Recruiting
Address
Center Outpatient Clinic, Public Institution
Vilnius, , LT-01117
Status
Recruiting
Address
Vilnius University Hospital Santariskiu Clinics, Public Institution
Vilnius, , LT-08661
Status
Not yet recruiting
Address
Clinicos Asociados BOCM S.C.
Mexico, Distrito Federal, 03300
Status
Not yet recruiting
Address
Centro de Investigacion ClÃnica GRAMEL S.C
Mexico, Distrito Federal, 03720
Status
Recruiting
Address
Comite Mexicano Para la Prevencion de Osteoporosis AC
Mexico, Distrito Federal, 06100
Status
Recruiting
Address
Clinstile, S.A. de C.V.
Mexico, Distrito Federal, 06700
Status
Recruiting
Address
Clinical Research Institute S.C.
Tlalnepantla, Estado De Mexico, 54055
Status
Recruiting
Address
Clinica de Investigacion en Reumatologia y Obesidad S.C.
Guadalajara, Jalisco, 44650
Status
Recruiting
Address
Centro de Estudios de Investigacion Basica y Clinica SC
Guadalajara, Jalisco, 44690
Status
Recruiting
Address
Accelerium S. de R.L. de C.V.
Monterrey, Nuevo León, 64000
Status
Withdrawn
Address
Hospital y Clinica OCA SA de CV
Monterrey, Nuevo León, 64000
Status
Recruiting
Address
Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez
Monterrey, Nuevo León, 64460
Status
Not yet recruiting
Address
Centro de Alta Especialidad en ReumatologÃa e Investigación del PotosÃ, S.C.
San Luis Potosi, San Luis Potos, 78213
Status
Recruiting
Address
Investigacion y Biomedicina de Chihuahua, S.C.
Chihuahua, , 31000
Status
Recruiting
Address
Centro de Alta Especialidad en ReumatologÃa e Investigación del PotosÃ, S.C.
San Luis PotosÃ, , 78213
Status
Recruiting
Address
CERMED
Bialystok, , 15-270
Status
Recruiting
Address
NZOZ ZDROWIE Osteo-Medic
Bialystok, , 15-351
Status
Recruiting
Address
Szpital Uniwersytecki nr 2 im.dr J. Biziela
Bydgoszcz, , 85-168
Status
Recruiting
Address
MCBK Iwona Czajkowska Anna Podra?ka- Szczepaniak S.C.
Grodzisk Mazowiecki, , 05-825
Status
Recruiting
Address
Polimedica Centrum Bada?, Profilaktyki I Leczenia
Kielce, , 25-364
Status
Recruiting
Address
CCBR - Lodz - PL
Lodz, , 90-368
Status
Recruiting
Address
Centrum Medyczne AMED
Lodz, , 91-365
Status
Recruiting
Address
ETYKA Osrodek Badan Klinicznych
Olsztyn, , 10-117
Status
Recruiting
Address
Szpital Wojewodzki im. Prymasa Kardynala Stefana Wyszynskiego
Sieradz, , 98-200
Status
Recruiting
Address
Clinmedica Research
Skierniewice, , 96-100
Status
Recruiting
Address
RCMed
Sochaczew, , 96-500
Status
Recruiting
Address
KO-MED Centra Kliniczne Staszow
Staszow, , 28-200
Status
Recruiting
Address
Samodzielny Publiczny ZOZ Tomaszow Lubelski
Tomaszow Lubelski, , 22-600
Status
Recruiting
Address
Niepubliczny Zaklad Opieki Zdrowotnej "Nasz Lekarz" Praktyka Grupowa Lekarzy Rodzinnych z
Torun, , 87-100
Status
Recruiting
Address
Medycyna Kliniczna
Warszawa, , 00-660
Status
Recruiting
Address
Rheuma Medicus Zaklad Opieki Zdrowotnej
Warszawa, , 02-118
Status
Recruiting
Address
McM Polimedica
Warszawa, , 02-777
Status
Recruiting
Address
KO-MED Centra Kliniczne Zamosc
Zamosc, , 22-400
Status
Recruiting
Address
Santa Familia Centrum Badan, Profilaktyki i Leczenia
Zgierz, , 95-100
Status
Not yet recruiting
Address
Centrul Medical Sana SRL
Bucuresti, , 011025
Status
Not yet recruiting
Address
Spitalul Clinic Judetean de Urgenta "Sf. Apostol Andrei" Constanta
Constanta, , 900591
Status
Not yet recruiting
Address
S.C Mediab S.R.L
Targu Mures, , 540142
Status
Recruiting
Address
Regional State Budgetary Healthcare Institution "Barnaul City Hospital #4"
Barnaul, Altai Region, 656050
Status
Recruiting
Address
Medical Center LLC "Maksimum Zdoroviya"
Kemerovo, Kemerovo Oblast, 650056
Status
Recruiting
Address
SAHI of Kemerovo region "Regional Clinical Hospital for War Veterans"
Kemerovo, Kemerovskaya Oblast, 650000
Status
Recruiting
Address
Budgetary Healthcare Institution "Kursk Regional Clinical Hospital" of Healthcare Committee of Kursk region
Kursk, Kurskaya Oblast, 305007
Status
Recruiting
Address
SPb SBHI "Clinical Rheumatological Hospital #25", Fourth Rheumatology Unit
Saint Petersburg, Leningradskaya Oblast, 190068
Status
Recruiting
Address
State Budgetary Healthcare Institution of Moscow "City Clinical Hospital #1 n.a. Pirogov" Healthcare Departament of Moscow
Moscow, Moscovskaya Oblast, 119094
Status
Recruiting
Address
FSBEI HE "First Moscow State Medical University n.a. I.M. Sechenov of MoH of Russian Federation", UCH #1
Moscow, Moscovskaya Oblast, 119991
Status
Recruiting
Address
FSBEI HE "FMSMU n.a. I.M. Sechenov of MoH of RF", University Hospital #2, Departament of New Drugs Introduction
Moscow, Moscovskaya Oblast, 119991
Status
Recruiting
Address
SBEI HPE "First Moscow State Medical University n.a. I.M. Sechenov of MoH of Russian Federation" UCH #3
Moscow, Moscovskaya Oblast, 119991
Status
Recruiting
Address
State Budgetary Healthcare Institution "City Clinical Hospital # 15 n.a O.M. Filatov" of Moscow Healtheare Department
Moscow, Moscow Region, 111539
Status
Recruiting
Address
SBHI of Moscow "City Clinical Hospital #4 of Moscow Healthcare Departament"
Moscow, Moskovskaya Oblast, 115093
Status
Recruiting
Address
SBHI of Nizhny Novgorod Region "Nizhny Novgorod Regional Clinical Hospital n.a.Semashko"
Nizhniy Novgorod, Nizhegorodskaya Oblast, 603126
Status
Recruiting
Address
State Autonomous Healthcare Institution of Novosibirsk region "City Polyclinic #1"
Novosibirsk, Novosibirsk Oblast, 630099
Status
Recruiting
Address
FSBRI "Research Institute of Therapy and Preventive Medicine"
Novosibirsk, Novosibirskaya Oblast, 630089
Status
Recruiting
Address
LLC "Clinical Diagnostic Center "Ultramed"
Omsk, Omskaya Oblast, 644024
Status
Recruiting
Address
Budgetary Healthcare Institution of Omsk Region "Regional Clinical Hospital"
Omsk, Omskaya Oblast, 644111
Status
Recruiting
Address
SBHI of the Republic of Karelia "Republican Hospital named after V.A. Baranov"
Petrozavodsk, Republic Of Karelia, 185019
Status
Recruiting
Address
State Budgetary Healthcare Institution "Republican Clinical Hospital n.a. G.G. Kuvatov"
Ufa, Respublic Of Bashkortostan, 450005
Status
Recruiting
Address
SBEI HPE "Rostov State Medical University" of Ministry of Health of the Russian Federation
Rostov, Rostovskaya Oblast, 344022
Status
Recruiting
Address
SBEI HPE "SSMU n.a. V.I. Razumovsky of MoH of RF", Clinical Hospital n.a. S.R. Mirotvorcev, Therapeutic Departament
Saratov, Saratovskaya Oblast, 410012
Status
Recruiting
Address
State Healthcare Institution "Regional Clinical Hospital"
Saratov, Saratovskaya Oblast, 410053
Status
Recruiting
Address
Non-governmental Healtheare Institution "Regional Clinical Hospital at Smolensk station of OJSC "Russian Railways"
Smolensk, Smolenskaya Oblast, 214025
Status
Recruiting
Address
SBHI of Stavropol Region "Stavropol Regional Clinical Hospital"
Stavropol', Stavropol Region, 355017
Status
Recruiting
Address
State Budgetary Healthcare Institution of Sverdlovsk Region "Sverdlovsk Regional Clinical Hospital #1"
Ekaterinburg, Sverdlovskaya Oblast, 620102
Status
Recruiting
Address
SBEI HPE "Ural State Medical University" of MoH of RF based MBI "Central City Clinical Hospital #6"
Ekaterinburg, Sverdlovskaya Oblast, 620149
Status
Recruiting
Address
State Autonomous Healthcare Institution "Republican Clinical Hospital of Ministry of Health of Tatarstan Republic
Kazan', The Republic Of Tatarstan, 420064
Status
Recruiting
Address
State Healthcare Institution of Tula region "Tula Regional Clinical Hospital"
Tula, Tulskaya Oblast, 300053
Status
Recruiting
Address
State Healthcare Institution "Ulyanovsk Regional Clinical Hospital"
Ulyanovsk, Ulyanovskaya Oblast, 432063
Status
Recruiting
Address
SBHI of Vladimir Region "Regional Clinical Hospital", Rheumatology Departament
Vladimir, Vladimirskaya Oblast, 600023
Status
Recruiting
Address
State Autonomous Helthcare Institution of Yaroslavl region "Clinical Hospital of Emergency Care n.a. Solovyev"
Yaroslavl, Yaroslavsakaya Oblast, 150003
Status
Recruiting
Address
SBHI "Yaroslavl Regional Clinical Hospital", Rheumatology department
Yaroslavl', Yaroslavskaya Oblast, 150062
Status
Recruiting
Address
FSBSI "Scientific Research Institute of Rheumatology n.a. V.A. Nasonova"
Moscow, , 115522
Status
Recruiting
Address
SBEI HPE "Saint Petersburg First State Medical University n.a. Acad. I.P. Pavlov" of Ministry of Healhcare of RF
Saint Petersburg, , 197022
Status
Recruiting
Address
SBHI "North-West Federat Medical Research Center n.a. V.A.Almazov" of the Ministry of Healthcare of the Russian Federation
Saint Petersburg, , 197341
Status
Recruiting
Address
China Medical University Hospital
Taichung, , 40447
Status
Recruiting
Address
Chi Mei Medical Center, Yung Kang Branch
Tainan, , 710
Status
Recruiting
Address
Tri-Service General Hospital
Taipei, , 11490
Status
Recruiting
Address
Chang Gung Memorial Hospital, Linkou
Taoyuan, , 333
Status
Recruiting
Address
Derriford Hospital
Plymouth, Devon, PL6 8DH
Status
Recruiting
Address
Torbay Hospital
Torquay, Devon, TQ2 7AA
Status
Recruiting
Address
Christchurch Hospital
Christchurch, Dorset, BH23 2JX
Status
Withdrawn
Address
Queen's Hospital
Romford, Essex, RM7 0AG
Status
Recruiting
Address
Whipps Cross University Hospital
London, Greater London, E11 1NR
Status
Recruiting
Address
Royal Free Hospital
London, Greater London, NW3 2QG
Status
Recruiting
Address
Basingstoke and North Hampshire Hospital
Basingstoke, Hampshire, RG24 9NA
Status
Recruiting
Address
Maidstone Hospital
Maidstone, Kent, ME16 9QQ
Status
Recruiting
Address
Arrowe Park Hospital
Wirral, Merseyside, CH49 5PE
Status
Withdrawn
Address
King's Mill Hospital
Nottingham, Nottinghamshire, NG17 4JL
Status
Withdrawn
Address
Glasgow Royal Infirmary
Glasgow, Strathclyde, G4 0SF
Status
Recruiting
Address
Ninewells Hospital
Dundee, Tayside Region, DD1 9SY
